Perihepatic lymphadenopathy in children with chronic viral hepatitis


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Journal of Ultrasonography

Polish Ultrasound Society (Polskie Towarzystwo Ultrasonograficzne)

Subject: Medicine


ISSN: 2084-8404
eISSN: 2451-070X





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VOLUME 15 , ISSUE 61 (June 2015) > List of articles

Perihepatic lymphadenopathy in children with chronic viral hepatitis

Dagmar Schreiber-Dietrich / Margret Pohl / Xin-Wu Cui / Barbara Braden / Christoph F. Dietrich / Liliana Chiorean

Keywords : ultrasonography, lymphadenopathy, chronic hepatitis, liver hilum, pediatric

Citation Information : Journal of Ultrasonography. Volume 15, Issue 61, Pages 137-150, DOI:

License : (CC BY-SA 4.0)

Received Date : 04-February-2015 / Accepted: 21-April-2015 / Published Online: 13-September-2016



Objective. To assess whether lymph node enlargement in the hepatoduodenal ligament occurs in children with chronic viral hepatitis B and C in comparison to healthy controls.

Subject and methods. In 49 patients with chronic viral hepatitis (38 with chronic hepatitis B, 11 with chronic hepatitis C, 31 male, 18 female; age range 1 to 17 years),

and in 51 healthy controls (25 male, 26 female; age range 4 to 16 years), the total perihepatic lymph node volume was assessed using transabdominal ultrasonography

as previously described in adult patients. 

Results. Adequate visualization of the liver hilum was achieved in 46/49 (94%) pediatric patients with chronic viral hepatitis and in 46/51 (90%) pediatric healthy controls. In patients with adequate liver hilum visualization,enlarged perihepatic lymph nodes (longitudinal diameter >14 mm) were detected in 32/46 (70%) patients with chronic viral hepatitis and in 5/46 (11%) healthy controls.

The total perihepatic lymph nodes volume [mean ± SD] was 1.0 ± 1.2 mL (0.1–5.4 mL) in patients with chronic viral hepatitis and 0.1 ± 0.1 mL (0.0–0.4 mL) in healthy controls  (p < 0.05). A maximal lymph node diameter >14 mm identifi ed patients with chronic viral hepatitis with 70% sensitivity and 89% specifi city. 

Conclusion. Transabdominal ultrasound can detect lymph nodes within the hepatoduodenal ligament not only in adults but also in children. Paediatric patients with chronic viral hepatitis have signifi -cantly enlarged perihepatic lymph nodes compared to controls. Therefore, sonographic assessment of perihepatic lymphadenopathy might be a non-invasive diagnostic tool to  screen paediatric patients for chronic viral hepatitis.

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