Early KPC-Producing Klebsiella pneumoniae Bacteremia among Intensive Care Unit Patients Non-Colonized upon Admission

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Polish Journal of Microbiology

Polish Society of Microbiologists

Subject: Microbiology

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ISSN: 1733-1331
eISSN: 2544-4646

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VOLUME 66 , ISSUE 2 (June 2017) > List of articles

Early KPC-Producing Klebsiella pneumoniae Bacteremia among Intensive Care Unit Patients Non-Colonized upon Admission

Matthaios Papadimitriou-Olivgeris / Fotini Fligou / Iris Spiliopoulou / Christina Bartzavali / Vasiliki Dodou / Sophia Vamvakopoulou / Kyriaki Koutsileou / Anastasia Zotou / Evangelos D. Anastassiou / Myrto Christofidou / Markos Marangos *

Keywords : bacteremia, carbapenemase, colistin-resistance, critically ill patients

Citation Information : Polish Journal of Microbiology. VOLUME 66 , ISSUE 2 , ISSN (Online) 2544-4646, DOI: 10.5604/01.3001.0010.7863, June 2017

License : (CC BY-NC-ND 4.0)

Received Date : 05-September-2016 / Accepted: 12-January-2017 / Published Online: 28-June-2017

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ABSTRACT

Among 140 patients colonized by KPC-producing Klebsiella pneumoniae (KPC-Kp) between fourth and seventh day of Intensive Care Unit stay, 24 developed bacteraemia immediately after colonization. Colistin-resistance of the colonizing isolate was the factor significantly associated with early KPC-Kp bacteraemia (P < 0.001; OR 6.6, 95% CI 2.4–18.4), a worrisome finding since infections by colistin-resistant isolates is associated with increased mortality due to limited remaining therapeutic options.

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