Early KPC-Producing Klebsiella pneumoniae Bacteremia among Intensive Care Unit Patients Non-Colonized upon Admission


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Polish Journal of Microbiology

Polish Society of Microbiologists

Subject: Microbiology


ISSN: 1733-1331
eISSN: 2544-4646





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VOLUME 66 , ISSUE 2 (June 2017) > List of articles

Early KPC-Producing Klebsiella pneumoniae Bacteremia among Intensive Care Unit Patients Non-Colonized upon Admission

Matthaios Papadimitriou-Olivgeris / Fotini Fligou / Iris Spiliopoulou / Christina Bartzavali / Vasiliki Dodou / Sophia Vamvakopoulou / Kyriaki Koutsileou / Anastasia Zotou / Evangelos D. Anastassiou / Myrto Christofidou / Markos Marangos *

Keywords : bacteremia, carbapenemase, colistin-resistance, critically ill patients

Citation Information : Polish Journal of Microbiology. Volume 66, Issue 2, Pages 251-254, DOI: https://doi.org/10.5604/01.3001.0010.7863

License : (CC BY-NC-ND 4.0)

Received Date : 05-September-2016 / Accepted: 12-January-2017 / Published Online: 28-June-2017



Among 140 patients colonized by KPC-producing Klebsiella pneumoniae (KPC-Kp) between fourth and seventh day of Intensive Care Unit stay, 24 developed bacteraemia immediately after colonization. Colistin-resistance of the colonizing isolate was the factor significantly associated with early KPC-Kp bacteraemia (P < 0.001; OR 6.6, 95% CI 2.4–18.4), a worrisome finding since infections by colistin-resistant isolates is associated with increased mortality due to limited remaining therapeutic options.

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Borer A., L. Saidel-Odes, S. Eskira, R. Nativ, K. Riesenberg, I. Livshiz-Riven, F. Schlaeffer, M. Sherf and N. Peled. 2012. Risk factors for developing clinical infection with carbapenem-resistant Klebsiella pneumoniae in hospital patients initially only colonized with carbapenem-resistant K. pneumoniae. Am. J. Infect. Control. 40: 421–425.


Chiang T.T., Y.S. Yang, K.M. Yeh, S.K. Chiu, N.C. Wang, T.Y. Lin, L.Y. Huang, F.Y. Chang, L.K. Siu, J.C. Lin and others. 2015. Quantification and comparison of virulence and characteristics of different variants of carbapenemase-producing Klebsiella pneumoniae clinical isolates from Taiwan and the United States. J. Microbiol. Immunol. Infect. 49: 83–90.


Diago-Navarro E., L. Chen, V. Passet, S. Burack, A. Ulacia-Hernando, R.P. Kodiyanplakkal, M.H. Levi, S. Brisse, B.N. Kreiswirth and B.C. Fries. 2014. Carbapenem-resistant Klebsiella pneumoniae exhibit variability in capsular polysaccharide and capsule associated virulence traits. J. Infect. Dis. 210: 803–813.


European Committee on Antimicrobial Susceptibility Testing (EUCAST). 2015. Breakpoint tables for interpretation of MICs and zone diameters. Version 5.0. http://www.eucast.org, 2016.06.23.


Falcone M., A. Russo, A. Iacovelli, G. Restuccia, G. Ceccarelli, A. Giordano, A. Farcomeni, A. Morelli and M. Venditti. 2016. Predictors of outcome in ICU patients with septic shock caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae. Clin. Microbiol. Infect. 22: 444–450.


Giacobbe D.R., V. Del Bono, E.M. Trecarichi, F.G. De Rosa, M. Giannella, M. Bassetti, A. Bartoloni, A.R. Losito, S. Corcione, M. Bartoletti and others. 2015. Risk factors for bloodstream infections due to colistin-resistant KPC-producing Klebsiella pneumoniae: results from a multicenter case-control-control study. Clin. Microbiol. Infect. 21(1106): e1–8.


Giannella M., E.M. Trecarichi, F.G. De Rosa, V. Del Bono, M. Bassetti, R.E. Lewis, A.R. Losito, S. Corcione, C. Saffioti, M. Bartoletti and others. 2014. Risk factors for carbapenem-resistant Klebsiella pneumoniae bloodstream infection among rectal carriers: a prospective observational multicentre study. Clin. Microbiol. Infect. 20: 1357–1362.


Queenan A.M. and K. Bush. 2007. Carbapenemases: the versatile beta-lactamases (table of contents). Clin. Microbiol. Rev. 20: 440–458.


Schechner V., T. Kotlovsky, M. Kazma, H. Mishali, D. Schwartz, S. Navon-Venezia, M.J. Schwaber and Y. Carmeli. 2013. Asymptomatic rectal carriage of blaKPC producing carbapenem-resistant Enterobacteriaceae: who is prone to become clinically infected? Clin. Microbiol. Infect. 19: 451–456.


Tischendorf J., R.A. de Avila and N. Safdar. 2016. Risk of infection following colonization with carbapenem-resistant Enterobactericeae: A systematic review. Am. J. Infect. Control. 44: 539–543