Erythromycin or Clindamycin – is it Still an Empirical Therapy against Streptococcus agalactiae in Patients Allergic to Penicillin?


Share / Export Citation / Email / Print / Text size:

Polish Journal of Microbiology

Polish Society of Microbiologists

Subject: Microbiology


ISSN: 1733-1331
eISSN: 2544-4646





Volume / Issue / page

Related articles

VOLUME 66 , ISSUE 2 (June 2017) > List of articles

Erythromycin or Clindamycin – is it Still an Empirical Therapy against Streptococcus agalactiae in Patients Allergic to Penicillin?

Piotr Leszczyński / Beata Sokół-Leszczyńska * / Bronisława Pietrzak / Anna Sawicka-Grzelak / Mirosław Wielgoś

Keywords : Streptococcus agalactiae, clindamycin, erythromycin, susceptibility on antibiotics

Citation Information : Polish Journal of Microbiology. Volume 66, Issue 2, Pages 265-268, DOI:

License : (CC BY-NC-ND 4.0)

Received Date : 11-August-2016 / Accepted: 27-January-2017 / Published Online: 28-June-2017



Retrospective analysis of Streptococcus agalactiae antibiotic susceptibility isolated in 2010–2013 was performed. Penicillin was still the first-line antibiotic. Due to the high percentage of strains resistant to erythromycin and clindamycin empirical treatment with these antibiotics may not be effective. Lower resistance rate to erythromycin and clindamycin among strains isolated from infected pregnant women and newborns were observed than among strains isolated from samples from patients hospitalized in other departments (29% and 47% v. 46% and 63%). The increasing resistance rate might give a rise to a new epidemiological situation.

Content not available PDF Share



Abdelazim I.A. 2013. Intrapartum polymerase chain reaction for detection of group B Streptococcus colonisation. Aust. NZJ Obstet. Gynaecol. 53(3): 236–242.


Arana D.M., B.R. Bezares and C.T. Manrique. 2014. First clinical isolate in Europe of clindamycin-resistant group B Streptococcus mediated by the lnu (B) gene. Rev. Esp. Qui 27(2): 106–109.


Bigos M., M. Łysakowska and M. Wasiela. 2012. Perinatal infections of etiology Streptococcus agalactiae (in Polish). Post. Mikrobiol. 51(4): 299–308.


Brown H.L., H.K. Ahmadzia and R.P. Heine. 2013. GBS Screening: An update on guidelines and methods. tags/bd-geneohm/gbs-screening-update-guidelines-and-methods, 2016.04.18.


Church D.L., H. Baxter and T. Lloyd. 2011. Evaluation of the Xpert group B Streptococcus real-time polymerase chain reaction assay compared to StrepB Carrot Broth for the rapid intrapartum detec-tion of group B streptococcus colonization. Diagn. Microbiol. Infect. Dis. 69: 460–462.


Clifford V., H.M. Heffernan and K. Grimwood. 2011. Variation in erythromycin and clindamycin resistance patterns between New Zealand and Australian group B Streptococcus isolates. NZJ Obstet. Gynaecol. 1(4): 328–332.


de-Paris F., A.B.M.P. Machado and T.C. Gheno. 2011. Group B Streptococcus detection: comparison of PCR assay and culture as a screening method for pregnant women. Braz. J. Infect. Dis. 15(4): 323–327.


Di Renzo G.C., P. Melin and A. Berardi. 2015. Intrapartum GBS screening and antibiotic prophylaxis: a European consensus conference. J. Matern. Fetal. Neonatal. Med. 28(7): 766–778.


Edwards R.K., P. Clark and P. Duff. 2002. Intrapartum antibiotic prophylaxis 2: positive predictive value of antenatal group B streptococci cultures and antibiotic susceptibility of clinical isolates. Obstet. Gynecol. 100: 540–544.


Helali N.E., Y. Giovangrandi and K. Guyot. 2012. Cost and effectiveness of intrapartum group B Streptococcus polymerase chain reaction screening for term deliveries. Obstet. Gynecol. 119: 822–829.


Kasahara K., A.K. Baltus and S.H. Lee. 2010. Prevalence of non-penicillin-susceptible group B Streptococcus in Philadelphia and specificity of penicillin resistance screening methods. J. Clin. Microb. 48 (4): 1468–1469.


National Institute for Health and Care Excellence. 2015. Xpert GBS test for the intrapartum detection of group B Streptococcus 63499051847365, 2016.04.18.


Poncelet-Jasserand E., F. Forges and M.N. Varlet. 2013. Reduction of the use of antimicrobial drugs following the rapid detection of Streptococcus agalactiae in the vagina at delivery by real-time PCR assay. BJOG 120: 1098–1108.


Savini V., R. Marrollo and M. D’Antonio. 2013. Case Report. Streptococcus agalactiae vaginitis: nonhemolytic variant on the Liofilchem Chromatic StreptoB. Int. J. Clin. Exp. Pathol. 6(8): 1693–1695.


Seo Y.S., U. Srinivasan and K.Y. Oh. 2010. Changing molecular epidemiology of group B Streptococcus in Korea. J. Korean Med. Sci. 25: 817–823.


Srinivasan V., B.J. Metcalf and K.M. Knipe. 2014. Van G element insertions within a conserved chromosomal site conferring vancomycin resistance to Streptococcus agalactiae and Streptococcus anginosus. mBio 5(4): e01386–14.


Szymusik I., K. Kosińska-Kaczyńska and B .Pietrzak. 2014. Is it time for a change in screening for GBS carriage? (in Polish). Ginekol. Pol. 85: 456–460.


Verani J.R., L. McGee and S.J. Schrag. 2010. Prevention of perinatal group B streptococcal disease: revised guidelines from CDC, 2010. MMWR 59(RR10): 1–32.


Verani J.R. and S.J. Schrag. 2010. Group B streptococcal disease in infants: progress in prevention and continued challenges. Clin. Perinat. 37: 375–392.