Antimicrobial Activity of Penicillin G and N-acetylcystein on Planktonic and Sessile Cells of Streptococcus suis


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Polish Journal of Microbiology

Polish Society of Microbiologists

Subject: Microbiology


ISSN: 1733-1331
eISSN: 2544-4646





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VOLUME 65 , ISSUE 1 (March 2016) > List of articles

Antimicrobial Activity of Penicillin G and N-acetylcystein on Planktonic and Sessile Cells of Streptococcus suis

Ivette Espinosa * / Michel Báez / Evelyn Lobo / Siomara Martínez / Marcelo Gottschalk

Keywords : Streptococcus suis, biofilm, N-acetylcystein, Penicillin G

Citation Information : Polish Journal of Microbiology. Volume 65, Issue 1, Pages 105-109, DOI:

License : (CC BY-NC-ND 4.0)

Received Date : 24-February-2015 / Accepted: 05-October-2015 / Published Online: 15-March-2016



The aim of this study was to investigate the capacity of Streptococcus suis strains to form biofilms and to evaluate the antimicrobial activity of Penicillin G and N-acetylcystein (NAC) on both S. suis sessile and planktonic forms. Only non-typeable isolates of S. suis were correlated with a greater biofilm formation capacity. The MCI of Penicillin G and NAC required for inhibiting biofilm growth were higher than the required concentration for inhibiting planktonic growth. The combinations of NAC and Penicillin G showed a strong synergistic activity that inhibited biofilm formation and disrupted the pre-formed biofilm of S. suis.

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