IgG Avidity: an Important Serologic Marker for the Diagnosis of Tick-Borne Encephalitis Virus Infection


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Polish Journal of Microbiology

Polish Society of Microbiologists

Subject: Microbiology


ISSN: 1733-1331
eISSN: 2544-4646





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VOLUME 65 , ISSUE 1 (March 2016) > List of articles

IgG Avidity: an Important Serologic Marker for the Diagnosis of Tick-Borne Encephalitis Virus Infection

Tatjana Vilibic-Cavlek * / Ljubo Barbic / Vladimir Stevanovic / Goranka Petrovic / Gordana Mlinaric-Galinovic

Keywords : IgG avidity, serology, tick-borne encephalitis virus

Citation Information : Polish Journal of Microbiology. Volume 65, Issue 1, Pages 119-121, DOI: https://doi.org/10.5604/17331331.1197285

License : (CC BY-NC-ND 4.0)

Received Date : 20-February-2015 / Accepted: 28-August-2015 / Published Online: 15-March-2016



A total of 52 serum samples from patients with symptoms suggestive of tick-borne encephalitis virus (TBEV) infection and positive IgM and/or IgG antibodies were tested for IgG avidity. Acute/recent TBEV infection was confirmed by low/borderline avidity index (AI) in 94.8% IgM positive/IgG positive samples, while in 5.2% high AI was found indicating persisting IgM antibodies. Majority of IgM negative/IgG positive samples (78.6%) showed high AI consistent with past TBEV infection. However, in 21.3% patients without measurable IgM antibodies current/recent infection was confirmed by AI. IgG avidity represents an additional serologic marker that improves diagnosis of TBEV, especially in cases of atypical antibody response.

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