The Effect of Local Platelet Rich Plasma Therapy on the Composition of Bacterial Flora in Chronic Venous Leg Ulcer


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Polish Journal of Microbiology

Polish Society of Microbiologists

Subject: Microbiology


ISSN: 1733-1331
eISSN: 2544-4646





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VOLUME 65 , ISSUE 3 (August 2016) > List of articles

The Effect of Local Platelet Rich Plasma Therapy on the Composition of Bacterial Flora in Chronic Venous Leg Ulcer

Witold Woźniak * / Monika Tarnas / Tomasz Miłek / R. Krzysztof Mlosek / Piotr Ciostek

Keywords : antibacterial activity, microflora of venous leg ulcer, platelet-rich plasma (PRP), venous leg ulcer

Citation Information : Polish Journal of Microbiology. Volume 65, Issue 3, Pages 353-357, DOI:

License : (CC BY-NC-ND 4.0)

Received Date : 22-January-2016 / Accepted: 06-June-2016 / Published Online: 26-August-2016



Microbial colonisation of chronic venous ulcers and synergism between bacterial species slow down the healing process. The study aimed at performing qualitative analysis of microbial flora in venous leg ulcers treated with platelet rich plasma (PRP). Twenty two women and twelve men aged 47–90 years were treated with PRP at our department between 2012 and 2015. Ulcer cultures collected before and after PRP therapy yielded 83 and 110 microbial isolates, respectively, of Gram positive, Gram negative bacteria and candida. Pseudomonas aueruginosa and Staphylococcus aureus were the most common pre-and post-treatment isolates. PRP therapy and increased the variety of microbial flora.

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