Search of the Antimicrobial Potential of Benzimidazole Derivatives

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Polish Journal of Microbiology

Polish Society of Microbiologists

Subject: Microbiology

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ISSN: 1733-1331
eISSN: 2544-4646

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VOLUME 65 , ISSUE 3 (August 2016) > List of articles

Search of the Antimicrobial Potential of Benzimidazole Derivatives

Monika Janeczko / Zygmunt Kazimierczuk / Andrzej Orzeszko / Andrzej Niewiadomy / Ewa Król / Ryszard Szyszka / Maciej Masłyk *

Keywords : antibacterial activity, antifungal activity, benzimidazole

Citation Information : Polish Journal of Microbiology. Volume 65, Issue 3, Pages 359-364, DOI: https://doi.org/10.5604/17331331.1215615

License : (CC BY-NC-ND 4.0)

Received Date : 16-December-2014 / Accepted: 11-February-2016 / Published Online: 26-August-2016

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ABSTRACT

A broad series of 4,5,6,7-tetrahalogenated benzimidazoles and 4-(1H-benzimidazol-2-yl)-benzene-1,3-diol derivatives was tested against selected bacteria and fungi. For this study three plant pathogens Colletotrichum sp., Fusarium sp., and Sclerotinia sp., as well as Staphylo­coccus sp., Enterococcus sp., Escherichia sp., Enterobacter sp., Klebsiella spp. , and Candida spp. as human pathogens were used. MIC values and/or area of growth reduction method were applied in order to compare the activity of the synthesized compounds. From the presented set of 22 compounds, only 8, 16, 18 and 19 showed moderate to good inhibition against bacterial strains. Against Candida strains only compound 19 with three hydroxyl substituted benzene moiety presented high inhibition at nystatin level or lower.

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