Antistaphylococcal Activity of Selected Thiourea Derivatives

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Polish Journal of Microbiology

Polish Society of Microbiologists

Subject: Microbiology

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ISSN: 1733-1331
eISSN: 2544-4646

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VOLUME 65 , ISSUE 4 (December 2016) > List of articles

Antistaphylococcal Activity of Selected Thiourea Derivatives

Joanna Stefańska * / Karolina Stępień / Anna Bielenica / Małgorzata Wrzosek / Marta Struga

Keywords : antistaphylococcal activity, anti-biofilm activity, genotoxicity, thiourea derivatives

Citation Information : Polish Journal of Microbiology. Volume 65, Issue 4, Pages 451-460, DOI: https://doi.org/10.5604/17331331.1227671

License : (CC BY-NC-ND 4.0)

Received Date : 20-August-2015 / Accepted: 08-March-2016 / Published Online: 28-December-2016

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ABSTRACT

Five of thiourea derivatives were prepared using as a starting compound 3-(trifluoromethyl)aniline, 4-chloro-3-nitroaniline, 1,3-thiazol-2-amine, 2H-1,2,3-triazol-4-amine and commercial isothiocyanates. All compounds were evaluated in vitro for antimicrobial activity. Derivatives 2 and 3 showed the highest inhibition against Gram-positive cocci (standard and hospital strains). The observed MIC values were in the range of 0.5–8 μg/ml. The products effectively inhibited the formation of biofilms of methicillin-resistant and standard strains of Staphylococcus epidermidis. Inhibitory activity of thioureas 2 and 3 against Staphylococcus aureus topoisomerase IV was studied. The examined compounds were nongenotoxic.

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