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Citation Information : Polish Journal of Microbiology. Volume 66, Issue 1, Pages 17-24, DOI: https://doi.org/10.5604/17331331.1234989
License : (CC BY-NC-ND 4.0)
Received Date : 17-November-2016 / Accepted: 27-January-2017 / Published Online: 30-March-2017
Group A Streptococcus (GAS) is a Gram-positive human pathogen that causes a variety of diseases ranging from pharyngitis to life-threatening streptococcal toxic shock syndrome. Recently, several global gene expression analyses have yielded extensive new information regarding the regulation of genes encoding known and putative virulence factors in GAS. A microarray analysis found that transcription of the GAS gene M5005_Spy_1343 was significantly increased in response to interaction with human polymorphonuclear leukocytes. M5005_Spy_1343 is predicted to encode a member of the LysR family of transcriptional regulators and is located upstream of a putative operon containing six genes. Five of these genes have sequence similarity to genes involved in short-chain fatty acid metabolism, whereas the sixth gene (luxS) is found in many bacterial species and is involved in quorum sensing. Unexpectedly, inactivation of the M5005_Spy_1343 gene resultedin hypervirulence in an intraperitoneal mouse model of infection. Increased virulence was not due to changes in luxS gene expression.We postulate that short-chain fatty acid metabolism is involved in GAS pathogenesis.
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