Antiviral Resistance of Splenocytes in Aged Mice

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Polish Journal of Microbiology

Polish Society of Microbiologists

Subject: Microbiology

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ISSN: 1733-1331
eISSN: 2544-4646

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VOLUME 66 , ISSUE 1 (March 2017) > List of articles

Antiviral Resistance of Splenocytes in Aged Mice

Ewa Zaczyńska * / Jolanta Artym / Maja Kocięba / Timo Burster / Marian Kruzel / Maria Paprocka / Michał Zimecki

Keywords : immune ageing, lactoferrin, mice, splenocytes, viral resistance

Citation Information : Polish Journal of Microbiology. VOLUME 66 , ISSUE 1 , ISSN (Online) 2544-4646, DOI: 10.5604/17331331.1235002, March 2017

License : (CC BY-NC-ND 4.0)

Received Date : 03-December-2015 / Accepted: 04-January-2017 / Published Online: 30-March-2017

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ABSTRACT

We compared the susceptibility to viral infection of splenocytes, isolated from young versus old CBA mice, and evaluated the antiviral actions of lactoferrin in splenocytes infected with Encephalomyocarditis virus (EMCV). Recombinant mouse lactoferrin (rmLF) and bovine lactoferrin (bLF) were used. There were no differences in the susceptibility to EMCV infection in the studied age categories. Both types of lactoferrins were protective in young and old mice. The study confirmed the undisturbed viral resistance in old mice and the protective actions of lactoferrin in viral infection. The antiviral action of the homologous mouse lactoferrin was demonstrated for the first time.

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