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  • Immunohematology


Report | 01-December-2019

A novel JK null allele associated with typing discrepancies among African Americans

The Jknull (Jk-3) phenotype, attributable to null or silenced alleles, has predominantly been found in persons of Polynesian descent. With the increased use of molecular genotyping, many new silencing mutations have been identified in persons of other ethnic backgrounds. To date, only two JK null alleles have been reported in African Americans, JK*01N.04 and JK*01N.05. A comparative study was undertaken to determine whether JK mutations were present in the regional African American population

Katrina L. Billingsley, Jeff B. Posadas, Joann M. Moulds, Lakshmi K. Gaur

Immunohematology, Volume 29 , ISSUE 4, 145–148

Report | 20-March-2020

A simple screening assay for the most common JK*0 alleles revealed compound heterozygosity in Jk(a–b–) probands from Guam

The Jk(a–b–) phenotype results from alterations in the JK gene and is characterized by absence of the RBC urea transporter in the cell membrane. The frequency of Jk(a–b–) varies among populations, but this phenotype is most commonly found in people of Polynesian and Finnish descent. Although rare, Jk(a–b–) individuals present a clinical challenge because anti-Jk3 is produced readily in response to transfusion and pregnancy, and Jk(a–b–) blood is

Elisabet Sjöberg Wester, Julia Gustafsson, Beverly Snell, Peggy Spruell, Åsa Hellberg, Martin L. Olsson, Jill R. Storry

Immunohematology, Volume 25 , ISSUE 4, 165–169

Article | 14-October-2020

Jk and Mi.III phenotype frequencies in North Vietnam

One hundred voluntary blood donors in Hanoi were typed for antigens in the MNS, Rh, Kell, Duffy, and Kidd blood group systems. They were also tested for the presence of the Mi.III (GP.Mur) phenotype and Lewis system antigens. The Jk phenotype frequencies were markedly different from those previously reported. The frequency of the Mi.III phenotype was similar to that reported in Chinese and Taiwanese.

Nguyen Thi Huynh, Tran Thi Duyen, Mai Thanh Huong, Derek S. Ford

Immunohematology, Volume 19 , ISSUE 2, 57–58

Review | 09-October-2019

A Caucasian JK*A/JK*B woman with Jk(a+b–) red blood cells, anti-Jkb, and a novel JK*B allele c.1038delG

The Kidd blood group on the red blood cell (RBC) glycoprotein urea transporter-B has a growing number of weak and null alleles in its gene SLC14A1 that are emerging from more widespread genotyping of blood donors and patients. We investigated a 64-year-old Caucasian woman of Polish-Czech descent who developed anti-Jkb detected in solid-phase RBC adherence testing within 12 days after 7 units of RBCs were transfused. Her RBCs subsequently typed Jk(a+b–) by licensed reagents and human

Glenn Ramsey, Ricardo D. Sumugod, Paul F. Lindholm, Jules G. Zinni, Jessica A. Keller, Trina Horn, Margaret A. Keller

Immunohematology, Volume 32 , ISSUE 3, 91–95

Article | 14-October-2020

Blood group antigen profile predicted by molecular biology - use of real-time polymerase chain reaction to genotype important KEL, JK, RHD, and RHCE alleles

The most clinically important blood group systems in transfusion medicine, excluding the ABO system, are the RH, Kell, and Kidd systems. Alloantibodies to antigens of these systems may be produced following blood transfusion or during pregnancy and can result in serious hemolytic transfusion reactions and hemolytic disease of the newborn.We developed rapid and robust techniques for RHD, RHCE, KEL, and JK genotyping with the use of a real-time polymerase chain reaction instrument. Two

Fernando Manuel Ferreira Araújo, Christiana Pereira, Fátima Monteiro, Isabel Henriques, Elsa Meireles, Pedro Lacerda, Ana Aleixo, Regina Celeste, Luis M. Cunha-Ribeiro, Maria J. Rodrigues

Immunohematology, Volume 18 , ISSUE 3, 59–64

Review | 26-October-2019

Kidd blood group system: a review

The Kidd blood group system has been recognized as clinically important in red blood cell (RBC) serology since its identification in 1951. Forty years later, the JK glycoprotein was determined to be a product of SCL14A1 and was identical to the urea transport protein UT-B produced by HUT11A. The functional role of the protein as a urea transporter in RBCs and kidney has been well documented. The polymorphism responsible for the antithetical antigens Jka and Jkb was identified in 1994 as c.838G

Janis R. Hamilton

Immunohematology, Volume 31 , ISSUE 1, 29–35

case-report | 30-September-2021

Development of anti-Jk3 associated with silenced Kidd antigen expression and a novel single nucleotide variant of the JK gene

within this system in clinical practice,3 infrequently, patients will manifest anti-Jk3, reflecting alloimmunization against the high-prevalence Jk3 antigen.2 From a patient/individual standpoint, although rare, such antibodies are most frequently encountered in those of Polynesian ancestry, but are also seen in other populations including those of Finnish ancestry, and are associated with a number of well-defined genetic variants in the JK alleles.4 We report a case of a Jknull phenotype with a

P.A. Manrai, A.J. Siddon, K.M. Hager, J.E. Hendrickson, M.A. Keller, C.A. Tormey

Immunohematology, Volume 37 , ISSUE 3, 109–112

Case report | 01-December-2019

Major non-ABO incompatibility caused by anti-Jka in a patient before allogeneic hematopoietic stem cell transplantation

A 49-year-old white man with blood group AB, D+ was found to have alloanti-Jka and -K when he developed a delayed hemolytic transfusion reaction before allogeneic hematopoietic stem cell transplant (HSCT). Given that his stem cell donor was blood group O, D+, Jk(a+), K–, rituximab was added to his conditioning regimen of fludarabine and melphalan to prevent hemolysis of engrafting Jk(a+) donor red blood cells. The patient proceeded to receive a peripheral blood stem cell transplant from a

Miriam Y. Kim, Preeti Chaudhary, Ira A. Shulman, Vinod Pullarkat

Immunohematology, Volume 29 , ISSUE 1, 11–14

Article | 17-February-2021

Severe hemolytic disease of the fetus and newborn due to anti-E and anti-Jka

with phototherapy, which continued for 4 days after birth. Blood samples from the mother, father, and baby were sent to the advanced laboratory for further immunohematologic workup. Anti-E and anti-Jka were identified in the mother’s sample (IgG CAT cards) with titers of 8 and 2, respectively. RBC phenotyping of the submitted samples showed the mother to be D+C+c+E–e+;Jk(a–b+), the father to be D+C+c+E+e+; Jk(a+b+), and the baby to be D+C+c+E+e+;Jk(a+b+). Anti-E and anti-Jka were recovered in an

S. Mandal, S. Malhotra, G. Negi, A. Tiwari, S. Mitra, S. Basu, P. Singh

Immunohematology, Volume 36 , ISSUE 2, 60–63

Article | 26-October-2020

Naturally-occurring anti-Jka in infant twins

transfusions. Red blood cells (RBCs) from the patient and her sister typed as Jk(a-b+) by direct hemagglutination and this phenotype was confirmed by negative adsorption and elution studies. Both infants' plasma samples were strongly reactive with 20 examples of Jk(a+) RBCs and nonreactive with 20 examples of Jk(a-) RBCs by SPRCA assays. Anti-Jka was not detected in either twins' plasma by indirect antiglobulin tests by tube method in low-ionic-strength saline solution or polyethylene glycol, or

Dawn H. Rumsey, Sandra J. Nance, Mary Rubino, S. Gerald Sandler

Immunohematology, Volume 15 , ISSUE 4, 159–162

Report | 01-December-2019

Blood group antigen distribution in Lao blood donors

systems including ABO, MNS, P1PK, Rh, Kell, Lewis, Duffy, Kidd, and Diego. The results show similar antigen prevalence to that among Northeast Thais for ABO, MNS, P1PK, Rh, Kell, and Duffy systems. In the ABO system, O was the highest at 37.72 percent, followed by 35.56 percent B, 19.83 percent A1, 6.47 percent A1B, and 0.43 percent A2B. The common phenotypes were D+C+E–c– e+ at 60.43 percent, M+N–S–s+ at 46.55 percent, Fy(a+b–) at 80.82 percent, Jk(a+b+) at 39.44 percent

Chirapha Keokhamphoui, Yupa Urwijitaroon, Douangchanh Kongphaly, Te Thammavong

Immunohematology, Volume 28 , ISSUE 4, 132–136

Report | 16-October-2019

Validity and reliability of serologic immunophenotyping of multiple blood group systems by ORTHO Sera with fully automated procedure

The increase of immunization against blood group antigens has reinforced the need for automated extensive blood typing. The aim of this study was to assess both the validity and reliability of red blood cell (RBC) automated agglutination technology in testing for antigens of Kidd (Jk), Duffy (Fy), and MNS (Ss) blood systems. ORTHO Sera (Ortho Clinical Diagnostics, Raritan, NJ) anti-Jka, anti-Jkb, Anti-Fya, anti-Fyb, anti-S, and anti-s reagents were each tested on RBC samples previously typed

Ugo Salvadori, Roberto Melotti, Daniela L'Altrella, Massimo Daves, Ahmad Al-Khaffaf, Laura Milizia, Rossana Putzulu, Renata Filippi, Aurelio Carolo, Giuseppe Lippi, Ivo Gentilini

Immunohematology, Volume 34 , ISSUE 4, 140–147

Report | 09-October-2019

Distribution of blood groups in the Iranian general population

%), C (2677; 77.04%), c (2557; 73.58%), and E (1059; 30.47%). In the Kell blood group system, 3293 (94.76%) samples were typed as K–k+. For the Kidd and Duffy blood group systems, the following were the most common phenotypes: Jk(a+b+) (1703; 49%), Jk(a+b–) (1006; 28.95%), Fy(a+b+) (1495; 43.02%), and Fy(a+b–) (1005; 28.92%). In the MNS blood group system, the following were the most common phenotypes: M+N+ (1668; 48%), M+N– (1310; 37.70%), S+s+ (1564; 45%), and S–s

Ehsan Shahverdi, Mostafa Moghaddam, Ali Talebian, Hassan Abolghasemi

Immunohematology, Volume 32 , ISSUE 4, 135–139

Case report | 09-October-2019

A suspected delayed hemolytic transfusion reaction mediated by anti-Joa

-Joa and anti-Jkb. Fortunately, the transfused RBC unit was Jk(b–). Therefore, the crossmatch incompatibility was attributed to anti-Joa, which targets a highprevalence antigen found in 100 percent of most populations. Two weeks after discharge, the patient returned in sickle vasoocclusive pain crisis. The patient was clinically stable, but her Hb was 6.7 g/dL.  One unit of Fy(a–), Jk(b–), C–, E–, K–, HbS– RBCs, which was weakly crossmatch-incompatible

Ryan P. Jajosky, Wendy C. Lumm, Scott C. Wise, Roni J. Bollag, James F. Shikle

Immunohematology, Volume 33 , ISSUE 2, 73–75

Case report | 14-December-2020

Case report and review: alloimmunization, delayed hemolytic transfusion reaction, and clinically significant anti-Yta in a patient with ß-thalassemia/sickle cell anemia

were identified. The direct antiglobulin test was positive, and the eluate contained anti-c and -Jka. The patient’s hematocrit continued to decrease to 14 percent. Transfusions were withheld and the patient recovered uneventfully. Separate 51Cr red blood cell survival studies showed significantly shortened survival of both autologous and R1R1, Jk(a-), Yt(a+) erythrocytes. This case illustrates the complexity of transfusion management in hemoglobinopathy patients.

Christopher D. Hillyer, Jacquelynn M. Hall, Karen O. Tiegerman, Eugene M. Berkman

Immunohematology, Volume 7 , ISSUE 4, 102–106

case-report | 25-June-2021

A case series highlighting a common approach to identifying anti-Jk3

American descent; and anti-Jk3 among individuals of Finnish, Asian, and Polynesian descent.1,2 The Kidd system was first described in the 1950s, and there are currently four known phenotypes: Jk(a–b+), Jk(a+b–), Jk(a+b+), and Jk(a–b–).3 The Jk(a–b–) phenotype was first described by Pinkerton et al.4 in a Filipina individual in 1959. Jk(a–b–) is uncommon among individuals of European descent (p < 0.01) and is more common among individuals of Finnish, Asian, and Polynesian descent.1,2,3,5 Antibodies in

D.J.A.M. Talabong, W.E. Kelley

Immunohematology, Volume 37 , ISSUE 2, 84–88

Article | 06-December-2020

Six monoclonal antibodies to the CD59 antigen

, including Rhnull; Oh; ii; Ko; FY:-1,-2,-3; JK:-1,-2,-3; S-s-U-; p; CO:-1,-2; Yt(a-); Jr(a-); Vel-; At(a-); Cr(a-); GE:-2,-3; Wr(a+b+); MkMk; Jo(a-); and Lan-. 2-aminoethylisotbiouronium bromide treatment of erythrocytes destroyed blotting and serologic reactivity of all six antibodies. Pronase treatment reduced serologic reactivity and blotting ability of all antibodies except BRlC 229. Reactivity of all six antibodies was reduced with RBCs from paroxysmal nocturnal hemoglobinuria patients. Flow

Jennifer A. Bryant, Anne Fletcher, Fang Fang Yuan

Immunohematology, Volume 9 , ISSUE 3, 68–73

Article | 14-October-2020

PEG adsorption of autoantibodies causes loss of concomitant alloantibody

latter anti-Jka reacted 1+ with Jk(a+b+) RBCs after ZZAP adsorption but was nonreactive with the same RBCs following PEG adsorption. Titers of six alloantibodies adsorbed with antigen-negative RBCs in PEG were markedly weaker (range 2 to 8) compared to saline controls (range 4 to 32). IgG levels for PEG adsorbed (range 128 to 243 mg/dL) were 50% lower than controls (range 265 to 505 mg/dL). Although PEG adsorption is effective in removing autoantibody, the precipitation of immunoglobulin by PEG may

W. John Judd, Louann Dake

Immunohematology, Volume 17 , ISSUE 3, 82–85

Article | 17-February-2021

Identification of rare blood types in southern Brazil: impact on transfusion support

Reserved NP 74 M Myelodysplastic syndrome k- — Routine 28 85 M Myelodysplastic syndrome k- — Scheduled 17 35 F Pregnancy Fy(a-b-) Anti-D Laboratory tests NP 9 F Congenital hip displacement Oh Anti-H Laboratory tests 2 27 F Sickle cell trait Tc (a–) — Laboratory tests NP 24 M Sickle cell disease Tc (a–) A nti-Tca Routine 7 69 M Arthritis k- Anti-k Urgency 2 31 F Pregnancy k- — Laboratory tests NP 86 F Subtrochanteric fracture Fy(a-b-) — Urgency 4 19 F Test requested Jk(a-b

C.D.S.R. de Araújo, B.A. Machado, C.D. Reche, L. Maroni, L.C. Garlet, M.M.P. dos Santos, M. Beber, A. Pasqualotti, L. Castilho

Immunohematology, Volume 36 , ISSUE 4, 152–156

Report | 09-October-2019

Red blood cell phenotype prevalence in blood donors who self-identify as Hispanic

percent of donors tested. The percentage of K+ donors in this population was 2.8 percent. The most prevalent Duffy phenotypes were Fy(a+b+) (35.9%), Fy(a+b–) (35.6%), and Fy(a–b+) (27%). Of the donors studied, 15.3 percent had an FY GATA mutation. Only 1.5 percent of the donors were Fy(a–b–). The Jk(a+b+) phenotype was found in nearly half of the population. M+N+S+s+ was the most prevalent MNS phenotype from that group, constituting 22.4 percent. A total of 95.7 percent of the

Chelsea A. Sheppard, Nicole L. Bolen, Beth Eades, Gorka Ochoa-Garay, Mark H. Yazer

Immunohematology, Volume 33 , ISSUE 3, 119–124

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