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  • Immunohematology

 

Article

Anti-Vel alloimmunization and severe hemolytic disease of the fetus and newborn

therapy has been noted to date. We report such a case recently encountered at our Fetal Center. Case Report The patient was a 31-year-old woman (gravida/para/abortus [GPA] = G2P1000) who was referred to our Fetal Center from a neighboring state for evaluation of Vel alloimmunization. Her past history was significant, with the finding of a positive antibody detection test and identification of anti-Vel during her previous pregnancy. Based on literature reports of only mild-to-moderate HDFN in

K.J. Moise, Y. Morales, M.F. Bertholf, S.N. Rossmann, Y. Bai

Immunohematology , ISSUE 4, 152–154

Original Paper

Modeling alloantibody formation to highincidence red blood cell antigens in immune responders using genotypic data  

Alloimmunization to red blood cell antigens is unpredictable and poorly understood. Patients who are negative for highincidence antigens (HIAs) are at risk for developing the corresponding antibodies. Molecular methods can easily predict the lack of an antigen and thus, the risk of an individual to become immunized. We examined the prevalence and risk factors for HIA alloimmunization in patients at risk based on genotyping results. Genotyping using a molecular method (HEA BeadChip&trade

Patricia A.R. Brunker, Keerthana Ravindran, R. Sue Shirey

Immunohematology , ISSUE 1, 9–14

Report

Trends of ABO and Rh phenotypes in transfusion-dependent patients in Pakistan

The objective of this study was to determine the prevalence of ABO and Rh phenotypes in the general Pakistan population. This information could be used to help reduce the rate of alloimmunization in patients with blood disorders, such as thalassemia major, who require frequent blood transfusions. A total of 242 patients with blood disorders requiring frequent blood transfusions were enrolled in the study. ABO and Rh typing was performed on samples from these patients using tube and gel methods

Nida Anwar, Munira Borhany, Saqib Ansari, Sana Khurram, Uzma Zaidi, Imran Naseer, Muhammad Nadeem, Tahir Shamsi

Immunohematology , ISSUE 4, 170–173

Report

Laboratory management of perinatal patients with apparently “new” anti-D

alloimmunizing events, and the physicians were asked their opinion on the likely cause for the anti-D. Based on survey responses, updated RhIG information, and results of follow-up serology, anti-D was determined to be attributable  to previously unreported RhIG in 44 of 91 (48.3%) cases and to active immunization (immune anti-D) in 36 of 91 cases (39.6%). A probable cause for alloimmunization was reported in 14 of 52 (26.9%) returned surveys. Anti-D alloimmunization continues to occur in our prenatal

Judith L. Hannon, Gwen Clarke

Immunohematology , ISSUE 3, 108–111

Case report

Two cases of the variant RHD*DAU5 allele associated with maternal alloanti-D  

(HDFN) as D alloimmunization can occur with some D variants. Here, we describe two cases of the RHD*DAU5 allele associated with maternal alloanti-D in patients of African ancestry. Two obstetric patients were initially serologically classified as D+ with negative antibody detection tests on routine prenatal testing. Repeat testing at delivery identified anti-D in both patients with no history of RhIG administration or transfusion. DNA sequencing revealed that both patients possessed the RHD*DAU5

Jennifer A. Duncan, Susan Nahirniak, Rodrigo Onell, Gwen Clarke

Immunohematology , ISSUE 2, 60–63

Review

DEL phenotype

associated with D alloimmunization. East Asian immigrants constitute 2.1 percent of the 318.9 million persons residing in the United States, and an estimated 2.8 percent are blood donors. Using these statistics, we estimate that 68–683 units of DEL RBCs from donors of East Asian ancestry are transfused as D– annually in the United States. Given the reports from East Asia of D alloimmunization attributed to transfusion of DEL RBCs, one would expect an occasional report of D alloimmunization in

Dong Hyang Kwon, S. Gerald Sandler, Willy Albert Flegel

Immunohematology , ISSUE 3, 125–132

Article

Applications of selected cells in immunohematology in a developing country: case studies

Ravi C. Dara Dara, Aseem Kumar Tiwari, Dinesh Arora, Subhasis Mitra, Geet Aggarwal, Devi Prasad Acharya, Gunjan Bhardwaj

Immunohematology , ISSUE 1, 27–35

Report

Human platelet antigen allelic diversity in Peninsular Malaysia

selection, and admixture with the relatively recent arrivals such as Chinese, Indians, and Malay subethnic groups. Medical consequences of this genetic complexity are also discussed, including the risks of platelet alloimmunization associated with random platelet transfusion and gestation.

Wan Ubaidillah Wan Syafawati, Zulkafli Zefarina, Zafarina Zafarina, Mohd Nazri Hassan, Mohd Nor Norazmi, Sundararajulu Panneerchelvam, Geoffrey Keith Chambers, Hisham Atan Edinur

Immunohematology , ISSUE 4, 143–160

review-article

Fetal cardiac function by three-dimensional ultrasound using 4D-STIC and VOCAL – an update

malformations. In recent years, functional echocardiography has been used to study fetuses with a structurally normal heart but who are susceptible to hemodynamic changes due to the presence of extra-cardiac conditions, including, among others, fetal growth restriction, tumors/masses, twin-to-twin transfusion syndrome, fetal anemia (Rh alloimmunization), congenital infections, or maternal diseases such as diabetes mellitus, systemic arterial hypertension, and Graves’ disease(8–11). The assessment of cardiac

Nathalie Jeanne Bravo-Valenzuela, Alberto Borges Peixoto, Milene Carvalho Carrilho, Ana Letícia Siqueira Pontes, Caroline Cevante Chagas, Christiane Simioni, Edward Araujo Júnior

Journal of Ultrasonography , ISSUE 79, 287–294

Review

A Caucasian JK*A/JK*B woman with Jk(a+b–) red blood cells, anti-Jkb, and a novel JK*B allele c.1038delG

the expressed exons 4–11. This allele has been provisionally named JK*02N.14, subject to approval by the International Society of Blood Transfusion Working Party. The site of this variant is closer to the C-terminus than that of any allele associated with the Jk(a–b–) phenotype reported to date. Routine genotyping of patients with RBC alloantibodies can reveal variants posing potential risk of alloimmunization. Continuing investigation of Kidd variants may shed light on the

Glenn Ramsey, Ricardo D. Sumugod, Paul F. Lindholm, Jules G. Zinni, Jessica A. Keller, Trina Horn, Margaret A. Keller

Immunohematology , ISSUE 3, 91–95

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