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Report | 16-October-2019

Blood chimerism in twins

Chimerism is a phenomenon in which an individual has cells with different genetic content from different zygotes. In dizygotic twins (DTs), chimerism is believed to occur through placental anastomoses that enable the bidirectional exchange of hematopoietic stem cells. Little is still known about chimerism frequency in twins, but several studies have shown a relation between chimerism and some conditions such as autism, Alzheimer’s disease, and a group of autoimmune diseases such as Sj

Letícia Tavares, Daiane Cobianchi da Costa, Anna Paula de Borba Batschauer, Luiz Fernando Job Jobim, Gisele Menezes Ewald, Carolina de Mello, Eduardo Samuel Alvarez Velazquez, Alexandre Geraldo

Immunohematology, Volume 34 , ISSUE 4, 151–157

Article | 15-April-2020

Chimerism and mosaicism are important causes of ABO phenotype and genotype discrepancies

DNA extracted from blood, buccal mucosal cells, and hair from the propositi and on DNA isolated from their parents’ blood. In all tissues tested from propositus #1, three loci demonstrated a double paternal and a single maternal DNA contribution,indicating that he was a chimera or a mosaic; in those from propositus # 2, one STR locus demonstrated a double paternal DNA contribution, indicating that he was a tetragametic chimera. Chimerism and mosaicism are uncommon but important causes of ABO

Duck Cho, Jin Sol Lee, Mark Harris Yazer, Jong Won Song, Myung Geun Shin, Jong Hee Shin, Soon Pal Suh, Mee Jeong Jeon, Ji Young Kim, Jong Tae Park, Dong Wook Ryang

Immunohematology, Volume 22 , ISSUE 4, 183–187

Article | 26-October-2020

Serologic and molecular investigations of a chimera

A chimeric individual possesses two or more genetically distinct cell populations. Although the chimerism may not be evident in all gene systems, various loci display greater numbers of alleles than genetically "normal" individuals. The proposita was referred for further laboratory investigation due to a rnixed-field ABO blood group reaction following routine antenatal testing. Various molecular (HLA class Il, ABO genotyping, and 10 short tandem repeat [STR] microsatellites) and

Nicole A. Mifsud, Albert P. Haddad, Cathie F. Hart, Jennifer A. Condon, Michael Swain, Rosemary L. Sparrow

Immunohematology, Volume 15 , ISSUE 3, 100–104

Short Communication | 01-December-2019

Unusual erythrocyte split chimerism in pregnancy after allogeneic stem cell transplantation

M.L. Barjas-Castro, A.C. Vigoritto, F.A. Moretto, V. Castro

Immunohematology, Volume 30 , ISSUE 3, 135–136

Article | 26-October-2019

Multiplex ligation-dependent probe amplification assay for blood group genotyping, copy number quantification, and analysis of  RH variants

, and software for analysis of the MLPA results is available free of charge. In addition to the analysis of genetic variation in blood group genes, a major advantage of the test is the ability to detect aberrations in gene copy numbers, which is especially useful for the determination of homo- or hemizygous status of RHD or other blood group genes and for detection of blood chimerism. A relatively large number of RH wild-type and mutation-specific probes are included in the assay, allowing an

Barbera Veldhuisen, C. Ellen van der Schoot, Masja de Haas

Immunohematology, Volume 31 , ISSUE 2, 58–61

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