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research-article | 30-November-2018

Alteration of oxidative stress markers and behavior of rats in a novel model of depression

tests for a depressive-like state in rodents (Forbes et al., 1996; Castagné et al., 2011). Moderate concentrations of reactive oxygen species (ROS) are important for a large number of physiological functions (Valko et al., 2007). However, when the concentration of ROS exceeds the antioxidant capacity of the organism, animal cells enter a state called oxidative stress that leads to oxidative damage of cellular components (Aitken et al., 2008). The brain is especially vulnerable to oxidative stress

Anna Gorlova, Dmitrii Pavlov, Eugene Zubkov, Yana Zorkina, Anatoly Inozemtsev, Anna Morozova, Vladimir Chekhonin

Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 3, 232–238

research-article | 07-July-2020

Putative shared mechanisms in autism spectrum disorders and attention deficit hyperactivity disorder, a systematic review of the role of oxidative stress

et al., 2011; Sandin et al., 2012). Additionally, iodine deficiency, even at a sub-clinical level, appear to contribute to an increased risk for both disorders (Blazewicz et al., 2016; Abel et al., 2017). Exposure to environmental pollutants and chemicals has also been suggested to increase the risk of autism and hyperactivity disorder (Dickerson et al., 2015; Tran and Miyake, 2017). Oxidative stress markers have been found in autism and ADHD, suggesting that increased oxidative stress may

Filipa Sa-Carneiro, Conceição Calhau, Rui Coelho, Margarida Figueiredo-Braga

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 2, 129–138

Research paper | 06-February-2018

Nicorandil attenuates neuronal mitochondrial dysfunction and oxidative stress associated with murine model of vascular calcification

enzymes, indicating a severe oxidative stress. The elevated brain mitochondrial enzymes like NADH dehydrogenase, and succinate dehydrogenase in the disease control groups, reversed to the near control level after nicorandil treatment. We observed that nicorandil was more effective when given after calcification. It reduced the biochemical alterations associated with calcium and phosphorous toxicity in the brain, by preserving mitochondria, the key target for treating neurodegenerative diseases.

Sriram Ravindran, Krithika Swaminathan, Abhinaya Ramesh, Gino A. Kurian

Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 1, 57–67

research-article | 24-June-2021

Angiotensin IV improves spatial memory in streptozotocin-induced diabetic rats by reducing oxidative stress and altering BDNF levels

neurodegenerative alterations are thought to play a role in the cognitive impairments. It has been suggested that disturbances in receptor levels and neurotransmitter release may lead to apoptosis in neurons which might impair cognitive function in individuals with DM (Moheet et al., 2015; Sadeghi et al., 2016). DM is also defined as a chronic metabolic disorder as it is characterized by increased oxidative stress. It has been reported that oxidative stress contributes greatly to the development of diabetes

Aysu Kilic, Savas Ustunova, Birsen Elibol, Huri Bulut, Ismail Meral, Gulderen Sahin

Acta Neurobiologiae Experimentalis, Volume 81 , ISSUE 2, 1–11

original-paper | 04-June-2020

Lactobacillus fermentum JX306 Restrain D-galactose-induced Oxidative Stress of Mice through its Antioxidant Activity

Introduction Oxidative stress refers to an imbalance, which is caused by high levels of reactive oxygen species (ROS) and low levels of antioxidant activity (Preiser 2012). The excessive ROS can damage enzymes, fatty acids, proteins, nucleic acids, and other physiological substances of cells, which leads to structure and function disorders (Dizdaroglu et al. 1992; Wu et al. 2014). The oxidative stress can cause various diseases, including amyotrophic lateral sclerosis, asthma, allergies, and


Polish Journal of Microbiology, Volume 69 , ISSUE 2, 205–215

review-article | 30-November-2020

Effects of vitamin E on neurodegenerative diseases: an update

INTRODUCTION Characterized by specific neuronal cell losses, neurodegenerative diseases are among the leading cause of disabilities in elderly people (Knight, 1997; Floyd and Hensley 2002, Ricciarelli et al., 2007). Oxidative stress has important roles in the pathogenesis of neurodegenerative diseases. It is known that oxidative stress levels in the brain increase with age (Floyd and Hensley, 2002). Oxidative stress occurs due to the presence of free radicals in high amounts and/or insufficient

Mehmet Arif Icer, Neslihan Arslan, Makbule Gezmen-Karadag

Acta Neurobiologiae Experimentalis, Volume 81 , ISSUE 1, 21–33

Research Article


Human population in the XXI century is struggling with the increasing incidence of such diseases as obesity, diabetes, cancers, food allergies and many others. Recent studies have shown that oxidative stress caused by reactive oxygen species and free radicals, may underlie the occurrence of many diseases. Probiotics are known for their beneficial effects on health and are established as dietary adjuncts. Researchers are trying to find potential probiotic strains which can exhibit antioxidant

Nina Trojan, Paweł Satora

Postępy Mikrobiologii - Advancements of Microbiology, Volume 56 , ISSUE 1, 18–27

Review | 31-July-2017

The physiology of blood platelets and changes of their biological activities in multiple sclerosis

Barbara Wachowicz, Agnieszka Morel, Elżbieta Miller, Joanna Saluk

Acta Neurobiologiae Experimentalis, Volume 76 , ISSUE 4, 269–281

research-article | 15-October-2020

Serum levels of hepcidin and interleukin 6 in Parkinson’s disease

INTRODUCTION The pathology of Parkinson’s disease (PD) is considered to be multifactorial. In addition to causing alterations in protein transformation, genetic defects and mitochondrial disfunction, the disease also induces chronic neuroinflammation and elevated oxidative stress processes. Neurodegeneration in PD is associated with complex relationships between immune-inflammatory pathways and peripheral tissues. Evidence for peripheral and central chronic inflammation in patients with PD

Jolanta Kwiatek-Majkusiak, Maciej Geremek, Dariusz Koziorowski, Ryszard Tomasiuk, Stanisław Szlufik, Andrzej Friedman

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 3, 297–304

Research paper | 06-February-2018

Effects of epidural compression on stellate neurons and thalamocortical afferent fibers in the rat primary somatosensory cortex

observed in some myelinated TCA fibers. In addition, expressions of oxidative markers 3-nitrotyrosine and 4-hydroxynonenal were elevated in barrel field post-lesion. Treatment of antioxidant ascorbic acid or apocynin was able to reverse the increase of oxidative stress and the decline of TCA fiber density, rather than the shrinkage of dendrites and the stripping of dendritic spines of stellate neurons post-lesion. Together, these results indicate that sustained epidural compression of primary

Tzu-Yin Yeh, Guo-Fang Tseng, Chi-Yu Tseng, Yung-Hsin Huang, Pei-Hsin Liu

Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 1, 1–17

Review | 04-May-2018

Developmental neurotoxicants and the vulnerable male brain: a systematic review of suspected neurotoxicants that disproportionally affect males

include: (1) greater glutathione availability in females; (2) greater sulfate-based detoxification capacity in females; (3) potentiating effects of co-exposure to neurotoxicants and testosterone; (4) greater neuroinflammatory response in males; (5) reduced vulnerability to oxidative stress in females; and (6) neuroprotective effects of female hormones (estrogen and progesterone), especially in the reduction of inflammation and oxidative stress.

Janet K. Kern, David A. Geier, Kristin G. Homme, Paul G. King, Geir Bjørklund, Salvatore Chirumbolo, Mark R. Geier

Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 4, 269–296

Research Article | 21-May-2019


Arsenic is an ubiquitous element present in the environment either through geological or anthropogenic activities. Millions of people all over the world are exposed to arsenic mainly via air, drinking water and food sources, which results in higher incidence of cancer. Several mechanisms by which arsenic compounds induce tumorigenesis have been proposed. Arsenic mediates its toxicity by generating oxidative stress, inducing protein misfolding, promoting genotoxicity, hampering DNA repair and

Seweryn Mucha, Mateusz Berezowski, Katarzyna Markowska

Postępy Mikrobiologii - Advancements of Microbiology, Volume 56 , ISSUE 1, 88–99

original-paper | 04-June-2020

N-acetylcysteine (NAC) Attenuating Apoptosis and Autophagy in RAW264.7 Cells in Response to Incubation with Mycolic Acid from Bovine Mycobacterium tuberculosis Complex

. 2018). Previous studies have shown that MTB lacking MA is less pathogenic in vivo, suggesting that MA plays an important role in MTB’s infection (Slama et al. 2016). Furthermore, MTB promotes bacterial survival by inducing oxidative stress in macrophages (Mohanty et al. 2016). Therefore, the strategy to alleviate the virulence of MTB is to inhibit the biosynthesis of MA, neutralize the oxidative stress produced by MA, and reduce the damage of ROS to intracellular substances. N-acetylcysteine (NAC


Polish Journal of Microbiology, Volume 69 , ISSUE 2, 223–229

Article | 30-November-2018


alkaline phosphatase (ALP) activity [15]. The exact mechanism of action of IS in this case is not known, but there are indications that it is related to the production of free radicals and oxidative stress [15]. Another problem in people with CKD is parathyroid hormone (PTH) impairment. The concentration of PTH increases with the decrease of GFR and is an expression of the organism’s defence against the decrease in calcium concentration. Can the change in the composition of a microbiota be one of the

Magdalena Nalewajska, Jarosław Przybyciński, Małgorzata Marchelek-Myśliwiec, Violetta Dziedziejko, Kazimierz Ciechanowski

Postępy Mikrobiologii - Advancements of Microbiology, Volume 58 , ISSUE 3, 237–245

Review Paper | 04-December-2013

Effect of plant polyphenols on seizures – animal studies

protect the brain against oxidative stress-induced damage suggests a potential use of some flavonoids at least as adjunctive therapy for the treatment of epilepsy.

Władysław Lasoń, Monika Leśkiewicz

Journal of Epileptology, Volume 21 , ISSUE 2, 79–87

review-article | 26-March-2021

Putative mechanism of neurological damage in COVID-19 infection

affect the availability of ACE2 to carry out the mentioned functions. It is also one of the strengths of SARS-CoV-2, when using ACE2 as a binding and entry agent to the host cell it disables the other mechanisms, decreasing the ability of the immune modulating tissue to respond by increasing the oxidative stress, inflammation and apoptosis. This proposed interaction is based on the pathway of the angiotensin II, which it’s binding to the AT1 receptor, leads to cellular damage through the effects

Cindy Bandala, José Luis Cortes-Altamirano, Samuel Reyes-Long, Eleazar Lara-Padilla, Ian Ilizaliturri-Flores, Alfonso Alfaro-Rodríguez

Acta Neurobiologiae Experimentalis, Volume 81 , ISSUE 1, 69–79

research-article | 30-November-2019

Crocin acts as a neuroprotective mediator against methylphenidate-induced neurobehavioral and neurochemical sequelae: Possible role of the CREB-BDNF signaling pathway

; Andreazza et al., 2007). MPH and other neuro-stimulant compounds can cause inflammation, oxidative stress, and mitochondrial dysfunction in brain cells; however the putative mechanism underlying these effects remains unknown (Martins et al., 2006). Interestingly, MPH-induced neurotoxicity seems to be more apparent in certain brain areas, particularly the hippocampus (including CA1, CA2, CA3, and DG subregions) and the amygdala (Morton and Stockton, 2000; Motaghinejad et al., 2017a). In recent years

Andia Ebrahimzadeh, Sara Yousefi Moghadam, Hanieh Rahimi, Majid Motaghinejad, Manijeh Motevalian, Sepideh Safari, Mobina Abbasi Mesrabadi

Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 4, 352–366

research-article | 30-November-2020

Regular aerobic exercise increased VEGF levels in both soleus and gastrocnemius muscles correlated with hippocampal learning and VEGF levels

quadrant (r=0.619, p<0.001). There was a strong positive correlation between VEGF levels of type 1 and type 2 muscle fibers (r=0.644 p<0.001). The VEGF levels also negatively correlated with oxidative stress parameters in type 2 fibers (VEGF and SOD levels, r=-0.366, p<0.05; VEGF and GPx levels, r=-0.364, p<0.05). In addition, there were strong positive correlations among SOD, GPx and MDA levels in type 1 and type 2 fibers (for type 1 muscle fiber: GPx and MDA, r=0.616, p<0.001; for type 2 muscle fiber

Asli Karakilic, Oguz Yuksel, Servet Kizildag, Ferda Hosgorler, Birsu Topcugil, Rabia Ilgin, Hikmet Gumus, Guven Guvendi, Basar Koc, Sevim Kandis, Mehmet Ates, Nazan Uysal

Acta Neurobiologiae Experimentalis, Volume 81 , ISSUE 1, 1–9

research-article | 30-June-2021

Effects of artemisinin and TSP-1-human endometrial-derived stem cells on a streptozocin-induced model of Alzheimer’s disease and diabetes in Wistar rats

identified in diabetes mellitus that lead to retinopathy and nephropathy (Cade, 2008). Increasing evidence demonstrates that oxidative stress has a crucial role in the expansion and progression of AD (Sharma and Gupta, 2002). Some studies proposed that amyloid-beta induces lipid peroxide, the creation of hydrogen peroxide, inflammatory cytokines, and superoxide in the brain (Esposito et al., 2006; Huang et al., 1999). Oxidative stress, through the generation of reactive oxygen species (ROS), is the main

Poorgholam Parvin, Yaghmaei Parichehreh, Noureddini Mehdi, Hajebrahimi Zahra

Acta Neurobiologiae Experimentalis, Volume 81 , ISSUE 2, 141–150

Article | 01-July-2019


consequence, to a reduction in their yielding [38, 110]. In this bacterium, the defence against the oxidative stress caused by the presence of H2O2 is the responsibility of, i.a., KatA and KatB catalases, which break down hydrogen peroxide into water and oxygen. In bacteria, the katA gene is expressed constitutively and the protein encoded by it is the dominant catalase during the logarithmic phase of growth and, in particular, in the stationary phase, and it plays a role in resistance to H2O2 and

Julia Berdychowska, Justyna Boniecka, Grażyna B. Dąbrowska

Postępy Mikrobiologii - Advancements of Microbiology, Volume 58 , ISSUE 2, 127–142

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