The constantly growing number of multidrug-resistant bacterial strains prompts the search for alternative treatments. Synthetic peptides based on natural antimicrobial peptides, also known as antimicrobial lipopeptides, can become a promising group of “drugs” to fight multi-resistant bacteria. The present paper discusses the origins of synthetic lipopeptides, their classification and antimicro- bial properties.
Postępy Mikrobiologii - Advancements of Microbiology , ISSUE 3, 213–227
fluorocytosines are the most commonly used drugs for the treatment of fungal infections; however, all have certain toxicity and side effects, and drug-resistant strains are constantly emerging. (Bellmann and Smuszkiewicz 2017; Spitzer et al. 2017). Therefore, the development of new antifungal drugs is urgently needed for clinical anti-infection treatment.
Antimicrobial peptides (AMPs), also known as host defense peptides, are biologically active molecules produced by various organisms as important components
Polish Journal of Microbiology , ISSUE 3, 383–390
What are immune peptides
Peptides of immunity – HDPs (Host Defense Peptides), form a complex of old, evolutionarily preserved effector molecules synthesized by the organisms of mammals (humans, animals – including marsupials and monotremes), birds, reptiles, amphibians, fish, insects and plants. Even microorganisms have not developed a defence mechanism against these substances along their evolutionary path, hence HDPs are often referred to as natural antibiotics [36, 56, 60, 87, 89, 93, 94
Postępy Mikrobiologii - Advancements of Microbiology , ISSUE 1, 19–28
Bacteriocins are ribosomally synthesized peptides or proteins exerting anatagonistic activity toward organisms which are closely related to the producer strain. Circular bacteriocins are produced by Gram-positive bacteria, mainly lactic acid bacteria, and to a lesser extent by Bacillus, Clostridium and Staphylococcus genera. These bacteriocins are characterized by the head-to-tail cyclization of their backbone. The circular nature of these peptides makes them resistant to many proteolytic
Postępy Mikrobiologii - Advancements of Microbiology , ISSUE 4, 451–464
Most of the lactic acid bacteria (LAB) are able to grow in milk mainly due to the activity of a complex and well-developed proteolytic system. Cell envelope-associated proteinases (CEPs) begin casein hydrolysis and allow for releasing the peptides, enclosed in the structure of native milk proteins that are essential for growth of Lactobacillus helveticus. The biodiversity of genes encoding CEPs among L. helveticus strains can have an effect on some technological parameters such as acid
KATARZYNA W. SKRZYPCZAK,
WALDEMAR Z. GUSTAW,
ADAM D. WAŚKO
Polish Journal of Microbiology , ISSUE 2, 203–211
JOHN J. CHUREY,
RANDY W. WOROBO,
Polish Journal of Microbiology , ISSUE 2, –
valylated cyclopropavir ester may have improved pharmacokinetic properties [7, 17, 29, 40].
Currently, phase 1 trials are being conducted to assess the safety and pharmacokinetics of cyclopropavir administered in healthy volunteers at various doses .
It is believed that peptide drugs may be an alternative for the treatment of viral infections. So far, studies have been concerned with their mechanism of action against viruses causing respiratory infections , HBV  and
Postępy Mikrobiologii - Advancements of Microbiology , ISSUE 3, 291–299
analysis confirmed the presence of plw structural gene encoding for plantacirin W in the selected L. plantarum strains. Moreover, we showed that the active peptides of Cys5-4 strains contrast effectively, in a bactericidal manner, the growth of food borne E. coli UTNEc1 and Salmonella UTNSm2, with about tree fold reduction of viable counts at the early stage of the target cell growth. The results indicated that the bacteriocin produced by selected native lactic acid bacteria strains has elevated
Gabriela N. Tenea
Polish Journal of Microbiology , ISSUE 4, 473–481
Introduction. Excessive accumulation of amyloid-beta (A_) peptides in the brain results initially in mild cognitive impairment (MCI) and finally in Alzheimer’s disease (AD). Evidences from experimental and clinical studies show that pathological hyperexcitability of hippocampal neurons is a very early functional impairment observed in progressive memory dysfunctions. Therefore, antiepileptic drugs (AEDs) whose mechanism of action is aimed at inhibition of such neuronal hyperexcitability
Journal of Epileptology , ISSUE 2, 139–147