Review Paper | 22-February-2013
Introduction. SUDEP is not so rare event, unexplained, underused and underestimated. Its awareness has recently contributed to a number of initiatives for global action and clinical and experimental research. Aim. To undertake a literature review so as to update various aspects of SUDEP: pathophysiological mechanisms, potential markers for autonomic dysfunctions and risk factors, AEDs effects, non-AED management options, forensic/autopsy, patient-physician communications in patients with SUDEP
Jerzy Majkowski
Journal of Epileptology, Volume 21 , ISSUE 1, 37–54
Review Paper | 26-March-2014
drugs (AEDs – lamotrigine, topiramate, levetiracetam, valproate and carbamazepine). Methods. A literature search for publications written in English, preferably published within a period of the last fifteen years, using the key words listed below. Review. The majority of AEDs possess more than one mechanism of action. They exert their effect by acting on various receptors (different types of glutamatergic and mainly GABAA receptors), neurotransmitters (mainly glutamate or GABA) and voltage
Magdalena Chrościńska-Krawczyk,
Magdalena Wałek,
Bożydar Tylus,
Stanisław J. Czuczwar
Journal of Epileptology, Volume 22 , ISSUE 1, 37–50
Review Paper | 10-December-2015
Introduction. Excessive accumulation of amyloid-beta (A_) peptides in the brain results initially in mild cognitive impairment (MCI) and finally in Alzheimer’s disease (AD). Evidences from experimental and clinical studies show that pathological hyperexcitability of hippocampal neurons is a very early functional impairment observed in progressive memory dysfunctions. Therefore, antiepileptic drugs (AEDs) whose mechanism of action is aimed at inhibition of such neuronal hyperexcitability
Krzysztof Sendrowski,
Wojciech Sobaniec
Journal of Epileptology, Volume 23 , ISSUE 2, 139–147
Case report | 31-March-2016
Background. Epilepsia partialis continua (EPC) is a difficult to treat condition, which tends to be refractory to antiepileptic drugs (AEDs). We previously published two other treatment episodes of EPC due to stroke and vascular dementia with a possible effect of perampanel (PER). Aim. With the publication of a third treatment episode of EPC terminated by the administration of PER we would like to suggest that PER may be an effective treatment option in this condition. Material and Methods. We
Katja Göde,
Annette Grossmann,
Johannes Rösche
Journal of Epileptology, Volume 24 , ISSUE 1, 67–70
review-paper | 23-March-2020
generalized one. SE is the first symptom of epilepsy in approximately 10% of cases (Amare et al., 2008). Epileptic patients display a higher risk of SE when they withdraw from taking AEDs. Other contributing factors include additional diseases or co-occurring metabolic dysfunctions (Towne et al., 1994). The risk of the occurrence of SE in individuals who had not been identified as epileptics could be increased by structural brain disturbances, metabolic disorders as well as toxic substances and addictions
Barbara Błaszczyk,
Aleksandra Walczak,
Natalia Ścirka,
Agnieszka Konarzewska,
Barbara Miziak,
Stanisław J. Czuczwar
Journal of Epileptology, Volume 28 , 43–54
Review Paper | 06-April-2016
seizures does not differ substantially from that applied to epilepsies from other etiologies. Therefore, the choice of an AED is based, above all, on tolerability and pharmacokinetic interactions with chemotherapeutic drugs. Levetiracetam is recommended by many authors as first-line therapy in brain tumor-related epilepsy. Due to the possibility of interactions, the combination of enzyme-inducing AEDs and chemotherapeutic drugs, is usually not recommended as a first choice. Currently there is no
Walter Fröscher,
Timo Kirschstein,
Johannes Rösche
Journal of Epileptology, Volume 24 , ISSUE 1, 41–56
research-article | 18-December-2018
(Cox et al., 2017). Monitoring can be used in patients with infrequent events, and tapering antiepileptic drugs (AEDs) has a beneficial effect on seizure frequency in this population (Al Kasab et al., 2016).
There is little consensus regarding the best AED withdrawal regimen during VEEG. A recent survey of epilepsy monitoring units (EMUs) revealed 80% of centers do not have a protocol for medication taper, and withdrawal is generally done on a case by case basis (Buelow et al., 2009). Guld et al
Alendia Hartshorn,
Yasser Shahrour,
Angeline S. Andrew,
Krzysztof Bujarski
Journal of Epileptology, Volume 26 , ISSUE 1-2, 15–19
research-article | 27-March-2019
and drug selection were based on the registration of AEDs, their reimbursement status in Poland, daily practice and personal views and experiences of epilepsy practitioners, as well as on the guidelines for the treatment of epilepsy published by the International League Against Epilepsy (Glauser et al., 2006), American Academy of Neurology (French et al., 2004a; 2004b), Scottish Intercollegiate Network Guidelines (SIGN, 2003) and the British Institute for Clinical Excellence (NICE, 2004). In 2018
Joanna Jędrzejczak,
Beata Majkowska-Zwolińska,
Danuta Ryglewicz,
Ewa Nagańska,
Maria Mazurkiewicz-Bełdzińska
Journal of Epileptology, Volume 27 , 9–16
original-paper | 22-July-2020
provides an educational, practical and organizational aspects. It will allow for the introduction of a uniform protocol of conduct in Poland, which in turn will improve the safety of the mother and her child.
The safety of breastfeeding while taking antiepileptic drugs (AEDs) is a serious concern for both women with epilepsy and their neurologists, obstetricians, neonatologists and paediatricians. Confirmation of these dilemmas is contained in the report “Practice parameter update” of the American
Joanna Jędrzejczak,
Maria Wilińska,
Ewa Kamińska,
Ryszard Lauterbach,
Ewa Helwich,
Teresa Jackowska,
Ewa Nagańska,
Natalia Jacyna,
Beata Majkowska-Zwolińska
Journal of Epileptology, Volume 28 , 7–25
Original Paper | 15-January-2018
Background. Adenosine is regarded as an endogenous anticonvulsant and its agonists have been proved to affect the anticonvulsant activity of a number of antiepileptic drugs (AEDs) in animal models of seizures. Aim. To evaluate effects of adenosine agonists on carbamazepine (CBZ) and valproate (VPA) in mouse model of generalized tonic-clonic convulsions. Methods. The following adenosine receptor agonists were used: A 1 – cyclohexyladenosine, A2A – CGS 21 680, A3 – N6-benzyl
Mirosław Jasiński,
Magdalena Chrościńska-Krawczyk,
Stanisław J. Czuczwar
Journal of Epileptology, Volume 25 , ISSUE 1-2, 21–29
Review Paper | 19-January-2015
magnetic stimulation (rTMS). Are these devices and techniques simply another treatment option that can be offered to patients with epilepsy or do they offer specific advantages when compared to the standard antiepileptic drugs (AEDs)? Aim. The aim of this review is to present the neurostimulation and neuromodulation devices and techniques that are now in use, or at least available for testing and to discuss the science behind them, their applications, efficacy, potential risks vs. benefits and, above
Lauren B. Bolden,
Sandipan Pati,
Jerzy P. Szaflarski
Journal of Epileptology, Volume 23 , ISSUE 1, 45–59
Original Paper | 22-December-2016
Introduction. Patients with pharmacoresistant epilepsy are usually treated with two or more antiepileptic drugs (AEDs). The search for therapeutically efficacious AED combinations is still a challenging issue for clinicians and epileptologists throughout the world. Aim. To determine the interaction profile for the combination of retigabine (RTG) and oxcarbazepine (OXC) in both, the model of tonic-clonic seizures, the maximal electroshock (MES)-induced seizure model and chimney test (motor
Mirosław Zagaja,
Barbara Miziak,
Katarzyna Załuska,
Paweł Marzęda,
Bartłomiej Drop,
Karolina Załuska-Patel,
Grażyna Ossowska,
Stanisław J. Czuczwar,
Jarogniew J. Łuszczki
Journal of Epileptology, Volume 24 , ISSUE 2, 87–94
Case report | 11-March-2014
Introduction. A significant number of patients suffering from epilepsy prove to be resistant to antiepileptic drugs (AEDs). Recent studies, however, suggest that 10–20% of seemingly drug resistant patients may still become seizure-free under the influence of subsequent dosage modifications. Case report. We report on a young man with cryptogenic focal epilepsy. He had his first seizure at the age of fifteen. His seizure frequency was decreased during the following 11 years. However
Walter Fröscher,
Alois Rauber
Journal of Epileptology, Volume 22 , ISSUE 1, 51–55
Case report | 14-November-2014
Introduction. Dominant presentation of ictal forced repetitive swearing has been rarely addressed and could be misdiagnosed. Case report. We report a 45-year-old man with a long history of right frontal lobe epilepsy (FLE) who developed forced repetitive swearing during hypermotor seizures. His seizures were refractory to different antiepileptic drugs (AEDs). Scalp video-EEG telemetry suggested a right frontal epileptic focus. Magnetic resonance imaging (MRI) suggested focal cortical dysplasia
Marjan Dolatshahi,
Alexei Yankovsky
Journal of Epileptology, Volume 22 , ISSUE 2, 113–119
Original Paper | 02-April-2015
course of disease were extracted from patients' charts. Drug resistant epilepsy was classified according to four definitions and the time until fulfillment of criteria compared. Results. Mean time to fulfillment of criteria of drug resistant epilepsy ranged from 11.8 (standard deviation (SD) 9.8) to 15.6 years (SD 11.3). Time to drug resistance was significantly longer applying the only definition, requiring failure of three antiepileptic drugs (AEDs) (Canada definition), whereas time to
Alexandra Rohracher,
Judith Dobesberger,
Claudia A. Granbichler,
Julia Höfler,
Giorgi Kuchukhidze,
Martin Ortler,
Iris Unterberger,
Gerald Walser,
Aljoscha Thomschewski,
Eugen Trinka
Journal of Epileptology, Volume 23 , ISSUE 1, 39–44
Review Paper | 30-September-2016
. Generalized tonic-clonic seizures and refractory epilepsy are the most important factors burdening PWE’s, resulting in increased injuries and mortality, including Sudden Unexpected Death in Epilepsy (SUDEP). The need of chronic intake of antiepileptic drugs (AEDs) and of epilepsy surgery are also important with regards to potential for side effects, drug interactions, and different surgery risks. PWE harbour more medical and psychiatric comorbidities than the general population and results in a
José Pimentel
Journal of Epileptology, Volume 24 , ISSUE 2, 167–172
Review Paper | 07-April-2017
include into genetic testing genes responsible for the side effects of AEDs. In addition, for some epilepsy phenotypes it has became possible to predict the most efficacious antiepileptic drugs for patients based on their genetic makeup. Thus, the development of individualized medicine is expected to greatly improve the management of epilepsy patients.
Heinz Gregor Wieser
Journal of Epileptology, Volume 22 , ISSUE 1, 11–23
research-article | 27-August-2018
pharmacotherapy, the percentage of non-responding patients has remained unchanged. The new generation AEDs, undoubtedly better tolerated and generally safer, have not, unfortunately, proved significantly more effective against epileptic seizures than the classical medicines (Hartman, Vining, 2007). Normally, the first administered AEDs leads to freedom from seizures in 50% of patients, the second in around 11%, the third in around 3%, whereas all subsequent AEDs work in only 0.8% of patients (Mohanraj, Brodie
Magdalena Dudzińska
Journal of Epileptology, Volume 26 , ISSUE 1-2, 27–47