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  • Acta Neurobiologiae Experimentalis


Research paper

Detrimental effects of chia (Salvia hispanica L.) seeds on learning and memory in aluminum chloride-induced experimental Alzheimer’s disease

Polyphenols and omega-3 fatty acids are thought to have beneficial effects in Alzheimer’s disease, the most common cause of dementia. Seeds of chia (Salvia hispanica L.) are highly rich in these nutrients, and thus, the present study investigated the effects of chia seeds on behavior and cognition in an aluminum-induced Alzheimer’s disease model in rats. Experimental animals received chia supplementation either during the generation of the model (i.e., pretreatment) or after the model was

Yasemin Bilgic, Enver Ahmet Demir, Nilufer Bilgic, Hatice Dogan, Okan Tutuk, Cemil Tumer

Acta Neurobiologiae Experimentalis , ISSUE 4, 322–331

Research paper

Long-term behavioral, histological, biochemical and hematological evaluations of amyloid beta-induced Alzheimer’s disease in rat

Alzheimer’s disease (AD) is a mental impairment and neural degeneration which causes progressive loss of memory and cognitive functions. This age-dependent illness is associated with extracellular amyloid plaques accumulation and twisted neurofibrillary tangles. Amyloid plaques are experimentally generated in animal models in order to investigate the disease process. In this study, we followed a rat model of AD for over a year. Wistar rats were divided randomly into two groups as control group

Raheleh Kheirbakhsh, Mahnaz Haddadi, Ahad Muhammadnejad, Alireza Abdollahi, Farshad Shahi, Behzad Amanpour-Gharaei, Azadeh Abrahim-Habibi, Tahereh Barati, Saeid Amanpour

Acta Neurobiologiae Experimentalis , ISSUE 1, 51–59


RhoA/Rock2/Limk1/cofilin1 pathway is involved in attenuation of neuronal dendritic spine loss by paeonol in the frontal cortex of D-galactose and aluminum-induced Alzheimer’s disease-like rat model

dendritic loss in the frontal cortex of D-galactose and aluminum-induced rat model of Alzheimer’s disease. METHODS Reagents and Drugs The chemical structure of paeonolsilate sodium (C9H9NaO6S, a derivative of paeonol) was shown in Fig. 1. Paeonolsilatie sodium injection (0.1g/2 ml), which has the same pharmacological effects as paeonol and has been approved by the Chinese FDA for clinical use in the treatment of muscle pain, arthralgia, rheumatism, neuralgia and abdominal pain (No.H20064790, http

Fei Han, Hui Xu, Jun-Xian Shen, Chuan Pan, Zong-Hao Yu, Jing-Jing Chen, Xiu-Ling Zhu, Ya-Fei Cai, Ya-Ping Lu

Acta Neurobiologiae Experimentalis , ISSUE 3, 225–244


Intracerebroventricular streptozotocin induces behavioral impairments and increases short-term C3 gene expression in the hippocampus of Wistar rats

INTRODUCTION Alzheimer’s disease (AD) is a progressive neurodegenerative disease which is clinically characterized by dementia and neurobehavioral impairments mainly on memory functions (Kar et al., 2004). Additionally, significant behavioral changes such as progressive memory loss, anxiety, agitation and irritability are observed. AD is categorized into two types: late-onset sporadic AD and early-onset familial AD (Dorszewska et al., 2016). The first one represents 95% of all the cases

Gabrielle Pfutzenreuter, Kenny Nieradka, Márcia Regina Pincerati, Ilton Santos da Silva

Acta Neurobiologiae Experimentalis , ISSUE 2, 160–169


The inhibitory effects of bile acids on catalytic and non-catalytic functions of acetylcholinesterase as a therapeutic target in Alzheimer’s disease

INTRODUCTION Alzheimer’s disease (AD) is a progressive dementia, hallmarked by amyloid plaque deposition and characterized by memory loss and cognitive dysfunction (Dong et al., 2012). Cumulative evidence strongly supports that decreased acetylcholine (ACh) neurotransmitter, as a result of acetylcholinesterase (AChE) hyperactivation, plays an important role in the occurrence and development of neurological disorders related to AD in patients and animal models (Anand and Singh, 2013). Therefore

Leila Sadeghi, Reza Yekta, Gholamreza Dehghan

Acta Neurobiologiae Experimentalis , ISSUE 2, 108–116


Navigating Unchartered Waters: A Nursing Perspective on Lewy Body Dementia

Madelaine B Rañola

Australasian Journal of Neuroscience , ISSUE 1, 5–12

Research paper

The effect of network template from normal subjects in the detection of network impairment

Chun‑Chao Huang, Shang‑Hua Lin, Ching‑Po Lin, The Alzheimer’s Disease Neuroimaging Initiative

Acta Neurobiologiae Experimentalis , ISSUE 4, 294–303


The role of DSCAM in the regulation of synaptic plasticity: possible involvement in neuropsychiatric disorders

Synaptic plasticity simply put, is the activity-dependent modification of the strength or efficacy of synaptic transmission in the network of synapses in the brain. The role of synaptic plasticity in disease is an active area of research. Changes in plasticity translate to the release of neurotransmitters at the synapse and subsequently, the way humans see the world. It is known that neuropsychiatric disorders such as depression, posttraumatic stress disorder (PTSD), and Alzheimer’s disease (AD

Katarzyna Stachowicz

Acta Neurobiologiae Experimentalis , ISSUE 3, 210–219



Fluorine is a common chemical element. According to WHO guidelines, the F- ion content in drinking water cannot be higher than 1.5 mg/dm3. Excess of fluorine leads to many health problems: Alzheimer’s disease, neurological disorders or fluorosis (dental or skeletal). Fluoride can be removed from aqueous solutions by means of various methods (adsorption, precipitation, ion-exchange or membrane techniques). The aim of this paper was to evaluate the efficiency of electrodialysis in fluoride


Architecture, Civil Engineering, Environment , ISSUE 4, 107–113


Subchronic effects of ligands of cannabinoid receptors on learning and memory processes of olfactory bulbectomized rats

avoidance paradigms. Future studies would add to our understanding of the contribution of the CB1 receptors to the mechanisms of memory impairment in depression and Alzheimer’s disease.

Margarita Velikova, Dobrinka Doncheva, Roman Tashev

Acta Neurobiologiae Experimentalis , ISSUE 3, 286–296


Cell-based immunofluorescence assay for screening the neurogenesis potential of new drugs in adult hippocampal neural progenitor cells

disorders. Some symptoms of these diseases can be explained by the dysregulation of adult neurogenesis (Winner and Winkler, 2015; Toda et al., 2019). Preclinical studies have suggested that increased adult neurogenesis in the hippocampus has potential therapeutic benefits in patients with Alzheimer’s disease and depression (Iqbal and Grundke-Iqbal, 2011; Miller and Hen, 2015; Han et al., 2016). This has led to adult neurogenesis as a target for the treatment of some brain diseases. Several methods can

Kun Zhang, Bin Li, Peifang Li, Xiaoli Yang, Huixian Cui, Xiaoyun Liu

Acta Neurobiologiae Experimentalis , ISSUE 3, 303–309

Research paper

Pharmacokinetics and pharmacodynamics of a novel Acetylcholinesterase Inhibitor, DMNG-3

distribution tissues of DMNG-3 in mice. It was found that DMNG-3 could be detected in brain, suggesting that DMNG-3 can cross the blood-brain barrier. The present study shows that DMNG-3 can be possible developed as a new drug for the treatment of Alzheimer’s disease in the future.

Xin-Guo Zhang, Fei Kou, Guo-Di MA, Peng Tang, Zhong-Duo Yang

Acta Neurobiologiae Experimentalis , ISSUE 2, 117–124

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