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research-paper

Coumarins as potential supportive medication for the treatment of epilepsy

INTRODUCTION Coumarins are organic, biologically active compounds belonging to the benzopyrone family (1,2-benzopyrones or 2H-1-benzopyran-2-ones). They are divided into four subtypes based on their chemical structure. Simple coumarins are formed by benzene rings fused with α-pirons which are hydroxylated, alkoxylated or alkylated at the C7, C6 and C3 positions of benzopyrone. Isocoumarin derivatives are formed by two rings: benzene and α-isopirone with substituents in positions C3, C6, C7 and

Jarosław Bryda, Mirosław Zagaja, Aleksandra Szewczyk, Marta Andres-Mach

Acta Neurobiologiae Experimentalis , ISSUE 2, 126–132

Research Article

Nematotoxic coumarins from Angelica pubescens Maxim. f. biserrata Shan et Yuan roots and their physiological effects on Bursaphelenchus xylophilus

The ethanol extracts from the roots of Angelica pubescens Maxim. f. biserrata Shan et Yuan was toxic against the pine wood nematode Bursaphelenchus xylophilus. The ethyl acetate-soluble fraction derived from this extract increased its potency with a mortality of 95.25% in 72 hr at 1.0 mg/mL. Four nematotoxic coumarins were obtained from the ethyl acetate extract by bioassay-guided isolation. These were identified as osthole 1, columbianadin 2, bergapten 3 and xanthotoxin 4 by mass and nuclear

Qun-Qun Guo, Gui-Cai Du, Yong-Xing Li, Chen-Yan Liang, Chao Wang, Ya-Nan Zhang, Rong-Gui Li

Journal of Nematology , ISSUE 4, 559–568

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