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Research paper

Marble burying as compulsive behaviors in male and female mice

Marble burying is considered an, albeit controversial, animal model of the compulsive like behaviors of obsessive-compulsive disorder (OCD). Hallmark features of OCD patients are similarities and, more prominent, differences from anxiety disorders, e.g., the absence of sex differences and resistance to spontaneous remission. We report an experiment on marble burying by male and female C57/BL6/N mice. Animals were administered either the classic anxiolytic drug, diazepam, that targets the GABA

George T. Taylor, Sandra Lerch, Sabine Chourbaji

Acta Neurobiologiae Experimentalis , ISSUE 3, 254–260

Research paper

Interaction between the serotoninergic and GABAergic systems in frog retina as revealed by electroretinogram

amplitude, while TACA alone caused its marked diminution. The relative amplitude diminution, caused by the TACA treatment, was significantly smaller when TACA was applied on the background of the fully developed serotonin effect. This result suggests that the retinal serotoninergic system could diminish the effects of ionotropic GABA receptor activation on the ERG wave generator mechanisms. In order to separately evaluate the effects of the GABAC receptor activation, in a subset of experiments the

Elka Popova, Petia Kupenova

Acta Neurobiologiae Experimentalis , ISSUE 4, 351–361


The role of DSCAM in the regulation of synaptic plasticity: possible involvement in neuropsychiatric disorders

synaptic plasticity. The review will present information on DSCAM and how it is connected to glutamate (Glu) and γ-Aminobutyric acid (GABA) neurotransmission pathways. Finally, the review throws some light on the possible involvement of DSCAM in a spectrum of psychiatric disorders apart from Down syndrome (DS).

Katarzyna Stachowicz

Acta Neurobiologiae Experimentalis , ISSUE 3, 210–219


Hindbrain metabolic deficiency regulates ventromedial hypothalamic nucleus glycogen metabolism and glucose-regulatory signaling

, 1998). Detection of neuro-energetic deficiency within the mediobasal hypothalamus (MBH), which contains the VMN as well as arcuate and tuberal hypothalamic nuclei, is critical for optimal contra-regulatory endocrine and hepatic gluconeogenic responses to hypoglycemia (Borg et al., 1997; 2003). The hypoglycemia-sensitive glucose-inhibitory neurotransmitter γ-aminobutyric acid (GABA) acts within the MBH to control counter-regulation by diminishing glucagon and epinephrine secretory responses to

Karen P. Briski, Santosh K. Mandal

Acta Neurobiologiae Experimentalis , ISSUE 1, 57–65


Gain analysis of high-speed DWDM link with different optical amplification configurations

Rajan Miglani, Gurjot Singh Gaba, Mehedi Masud, Roobaea Alroobaea

International Journal on Smart Sensing and Intelligent Systems , ISSUE 1, 1–8


Nigrostriatal interaction in the aging brain: new therapeutic target for Parkinson’s disease

Janusz W. Błaszczyk

Acta Neurobiologiae Experimentalis , ISSUE 1, 106–112


Impact of Hybrid PAPR Reduction Techniques on FBMC for 5G Applications

Satwinder Kaur, Lavish Kansal, Gurjot Singh Gaba, Fahad Alraddady, Sandeep Kumar Arora

International Journal on Smart Sensing and Intelligent Systems , ISSUE 1, 1–10

Review Paper

Selected classical and novel antiepileptic drugs – mechanisms of action, neuroprotection, and effectiveness in epileptic and non-epileptic conditions

drugs (AEDs – lamotrigine, topiramate, levetiracetam, valproate and carbamazepine). Methods. A literature search for publications written in English, preferably published within a period of the last fifteen years, using the key words listed below. Review. The majority of AEDs possess more than one mechanism of action. They exert their effect by acting on various receptors (different types of glutamatergic and mainly GABAA receptors), neurotransmitters (mainly glutamate or GABA) and voltage

Magdalena Chrościńska-Krawczyk, Magdalena Wałek, Bożydar Tylus, Stanisław J. Czuczwar

Journal of Epileptology , ISSUE 1, 37–50

Review Paper

The role of cannabinoids and endocannabinoid system in the treatment of epilepsy

many biochemical and physiological processes. By affecting glutamate and gamma-aminobutyric acid (GABA) neurotransmission cannabinoids have the ability to affect seizure threshold. The best known cannabinoid is cannabidiol, which inhibits the occurrence of seizures without causing significant side effects in humans and animals. However, only a small number of double blind, randomized and placebo controlled studies have been published to date. Conclusions. The role of cannabinoids in the treatment

Monika Pędracka, Jacek Gawłowicz

Journal of Epileptology , ISSUE 2, 131–138

case report

Zolpidem in treatment resistant adolescent catatonia: a case series

intense inner anxiety(14). Hence, benzodiazepines through facilitatory action on the GABA-A Receptor (GABAAR) improve the catatonic symptoms (15). It is also proposed that the catatonia is characterized by hypokinetic and hyperkinetic movements similar to Parkinson’s disease which is suggestive of dysfunction of different neuronal motor circuits. One of the important circuits which can be included in causing inhibition and excitation of movements, comprises a circuit from the primary motor cortex (PMC

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology , 135–138

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