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  • Australasian Journal Of Neuroscience
  • Acta Neurobiologiae Experimentalis



Dichlorodiphenyltrichloroethane (DDT) induced extracellular vesicle formation: a potential role in organochlorine increased risk of Parkinson’s disease

A number of studies have demonstrated that rural living and exposure to pesticides such as dichlorodiphenyltrichloroethane (DDT) highly increase the chances of developing Parkinson’s disease. In a previous work, we have found that DDT leads to the formation of vesicular buds that are released from the cells upon fusion of an intermediate endocytic compartment with the plasma membrane. Since extracellular vesicles like exosomes have been implicated in the development of neurodegenerative

Mario Rossi, Marco Scarselli, Irene Fasciani, Roberto Maggio, Franco Giorgi

Acta Neurobiologiae Experimentalis , ISSUE 2, 113–117


Purposeful collaboration: Enriching lives for people with Parkinson’s disease

Introduction: Parkinson’s disease (PD) is a progressive neurological disorder caused by the loss of dopamine producing cells in the substantia nigra, which is located in the basal ganglia. As dopamine assists with transmitting and modulating signals in the brain, ongoing dopamine depletion causes motor, autonomic and cognitive impairments (Magrinelli et al., 2016). PD is characterised by motor symptoms that are associated with movement (e.g. bradykinesia, rigidity, postural instability, tremor

Vincent Carroll, Kirsten Deutschmann, Jessica Andrews

Australasian Journal of Neuroscience , ISSUE 1, 32–43


Serum levels of hepcidin and interleukin 6 in Parkinson’s disease

INTRODUCTION The pathology of Parkinson’s disease (PD) is considered to be multifactorial. In addition to causing alterations in protein transformation, genetic defects and mitochondrial disfunction, the disease also induces chronic neuroinflammation and elevated oxidative stress processes. Neurodegeneration in PD is associated with complex relationships between immune-inflammatory pathways and peripheral tissues. Evidence for peripheral and central chronic inflammation in patients with PD

Jolanta Kwiatek-Majkusiak, Maciej Geremek, Dariusz Koziorowski, Ryszard Tomasiuk, Stanisław Szlufik, Andrzej Friedman

Acta Neurobiologiae Experimentalis , ISSUE 3, 297–304


The application of iPSCs in Parkinson’s disease

INTRODUCTION The medical research and application of induced pluripotent stem cells (iPSCs) is advancing rapidly. Although iPSCs are potentially applicable in several different fields of medical research and for clinical purposes (Takahashi and Yamanaka, 2006), they have proven to be particularly valuable in the research of neurodegenerative disease research e.g., Parkinson’s disease (PD) (Zhu et al., 2019). PD is characterised by the degeneration of the midbrain dopaminergic (mDA) neurons that

Josefine Jul Jarbæk Nielsen, Thea Pinholt Lillethorup, Andreas Nørgaard Glud, Jens Christian Hedemann Sørensen, Dariusz Orlowski

Acta Neurobiologiae Experimentalis , ISSUE 3, 273–285


Nigrostriatal interaction in the aging brain: new therapeutic target for Parkinson’s disease

Parkinson’s disease (PD) is a progressive neurodegenerative disorder of unclear etiology and pathogenesis. Research results gathered to date support the hypothesis that the motor symptoms of the disease result from the gradual loss of midbrain dopamine neurons residing in the substantia nigra pars compacta (SNpc). Recent discoveries, however, significantly expand this knowledge indicating that the primary source of the PD pathogenesis may be located both in the SNpc as well as in the GABAergic

Janusz W. Błaszczyk

Acta Neurobiologiae Experimentalis , ISSUE 1, 106–112


Navigating Unchartered Waters: A Nursing Perspective on Lewy Body Dementia

Introduction Definition “Lewy body dementia” (LBD) is broadly considered to consist of two related disorders-Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB) (Connors et al., 2017). Neuro-pathologically, these spectrum disorders are characterised by the widespread distribution of aggregated a-synuclein, forming structures called Lewy bodies in neuronal cell bodies and processes (Galasko, 2017; Stubendorrf, Aarsland, Minthon & Londos, 2012). The abnormal clumping and

Madelaine B Rañola

Australasian Journal of Neuroscience , ISSUE 1, 5–12


The interplay between parkin and alpha-synuclein; possible implications for the pathogenesis of Parkinson’s disease

INTRODUCTION Parkinson’s disease (PD) is one of the most common age-related neurodegenerative disorders. Despite years of intense research and testing of candidate treatments, all available therapies are symptomatic. The long period of stealthy, relatively symptom-free development is shared with other neurodegenerative disorders (notably, with Alzheimer’s disease – AD), and hampers diagnosis, elucidation of disease mechanisms, and possible therapy (reviewed in Jęśko et al., 2017). The main

Henryk Jęśko, Anna M. Lenkiewicz, Anna Wilkaniec, Agata Adamczyk

Acta Neurobiologiae Experimentalis , ISSUE 3, 277–290


The complications of jejunostomy tubes for patients receiving Duodopa: New challenges for neuroscience nurses

Background: An 80 year old man with advanced Parkinson’s disease (PD) was admitted to the neuroscience unit with a worsening decline in mobility. Medical management was the commencement and titration of the levodopacarbidopa intestinal gel (LCIG) Duodopa ® via a naso-jejunal tube, which had been inserted under fluoroscopy in Interventional Radiology. Over a ten day trial period the patient responded well to the administration of the LCIG with much less periods of difficulty with movement (known

Rachael Elizabeth Mackinnon

Australasian Journal of Neuroscience , ISSUE 2, 1–4

Research paper

Effects of PINK1 mutation on synapses and behavior in the brain of Drosophila melanogaster

Mutations in the PINK1 gene are responsible for typical symptoms of Parkinson’s disease. Using Drosophila melanogaster mutant PINK1B9 and after PINK1 silencing with RNAi using transgenic lines, we observed defects in synapses and behavior. The lack or reduced expression of PINK1 prolonged sleep during the day (nap) and decreased the total locomotor activity during 24 h, in addition to a decrease in climbing ability and a reduced lifespan. In the brain, PINK1 mutants had a lower level of

Bartosz Doktór, Milena Damulewicz, Wojciech Krzeptowski, Barbara Bednarczyk, Elżbieta Pyza

Acta Neurobiologiae Experimentalis , ISSUE 3, 231–241

Research paper

Continuous MPTP intoxication in the Göttingen minipig results in chronic parkinsonian deficits

Parkinson’s disease (PD) is a common neurodegenerative disorder, resulting from progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNc). Neuroprotective therapies in PD are still not available, perhaps because animal models do not imitate the chronic and progressive nature of the clinical state of PD. To address this, we performed a feasibility study aimed at establishing a chronic non-primate large animal PD model in Göttingen minipigs based on continuous infusion

Mette Slot Nielsen, Andreas Nørgaard Glud, Arne Møller, Poul Mogensen, Dirk Bender, Jens Christian Sørensen, Doris Doudet, Carsten Reidies Bjarkam

Acta Neurobiologiae Experimentalis , ISSUE 3, 199–211


Lubag Syndrome (X-linked Dystonia Parkinsonism) Case Study of Mr G. Infante

unaffected father and a carrier mother. While the underlying mechanisms of DBS are not yet fully understood, it allows changes in brain activity to be made in a controlled manner (Herrington, Cheng & Eskandar 2016). Prior to DBS surgical lesioning was the primary surgical intervention for Parkinson’s Disease (PD) and dystonic conditions. This involves the insertion of a heated electrode into structures within the basal ganglia, destroying cells within a very small area and disrupting electrical brain

Vincent Cheah

Australasian Journal of Neuroscience , ISSUE 1, 7–10

Research paper

Afferent projections of the subthalamic nucleus in the rat: emphasis on bilateral and interhemispheric connections

The subthalamic nucleus (STN) is important for normal movement as well as in movement disorders. The STN is a target nuclei in patients with advanced Parkinson’s disease (PD). Deep brain stimulation (DBS) is a standard surgical treatment for PD. Although DBS results in a significant reduction in motor disability, several negative side effects have been reported. Thus, to understand the side effects of DBS the connection of the STN should be well known. Therefore, the present study aims to re

Safiye Çavdar, Merve Özgür, Yusuf Özgür Çakmak, Yasemin Kuvvet, Sıla Kezban Kunt, Gökay Sağlam

Acta Neurobiologiae Experimentalis , ISSUE 3, 251–263

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