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Acta Neurobiologiae Experimentalis

research-article | 07-July-2020

Effects of HCN channel blockade on the intensity-response function of electroretinographic ON and OFF responses in dark adapted frogs

saturation of the pathways receiving inputs from the rod system. In none of the papers cited one could find any information concerning the role of HCN channels in the OFF response generation in distal retina, which is reflected in the ERG d-wave. In this study we investigated the effects of pharmacological blockade of HCN channels (with ZD7288 or ivabradine) on the ERG ON and OFF responses, obtained with a wide range of stimulus intensities in dark adapted frog eyecups. Both blockers inhibit all isoforms

Elka Popova, Petia Kupenova

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 2, 192–204