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  • Acta Neurobiologiae Experimentalis

 

Research paper | 01-August-2017

The false-positive responses of analgesic drugs to the intradermal serotonin- and compound 48/80-induced scratches as an animal model of itch

animal model of itch differentiates itch or pain to show efficacy of clinically effective analgesic drugs as a back translation. In this study, we explored the effects of different group of analgesic drugs on serotonin and compound 48/80-induced scratching behavior in Balb-C mice. Serotonin (25 μg) and compound 48/80 (100 μg) was injected intradermally in a volume of 50 μl into the rostral part of skin on the back of male mice and scratches were counted for a 30-min observation period. Morphine (1, 3

Fatih Ilkaya, Ozgur Yesilyurt, Melik Seyrek, Ozgur Gunduz, Tayfun Ide, Ahmet Akar, Ahmet Ulugol, Hasan Guzel, Ahmet Dogrul, Durmus Ucar, Caner Gunaydin

Acta Neurobiologiae Experimentalis, Volume 76 , ISSUE 3, 234–243

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