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  • Acta Neurobiologiae Experimentalis


Research paper

The false-positive responses of analgesic drugs to the intradermal serotonin- and compound 48/80-induced scratches as an animal model of itch

Intradermal injection of pruritogens such as serotonin, histamine and compound 48/80 into the skin and then, the evaluation of the scratching behavior is the commonly used animal model to advance pruritic research and drug development. However, predictive validity of this model is poorly documented. There is a close interaction between itch and pain sensations with regard to mediation through an anatomically and functionally identical neuronal pathway. One approach is whether the existing

Fatih Ilkaya, Ozgur Yesilyurt, Melik Seyrek, Ozgur Gunduz, Tayfun Ide, Ahmet Akar, Ahmet Ulugol, Hasan Guzel, Ahmet Dogrul, Durmus Ucar, Caner Gunaydin

Acta Neurobiologiae Experimentalis , ISSUE 3, 234–243

Research paper

Marble burying as compulsive behaviors in male and female mice

Marble burying is considered an, albeit controversial, animal model of the compulsive like behaviors of obsessive-compulsive disorder (OCD). Hallmark features of OCD patients are similarities and, more prominent, differences from anxiety disorders, e.g., the absence of sex differences and resistance to spontaneous remission. We report an experiment on marble burying by male and female C57/BL6/N mice. Animals were administered either the classic anxiolytic drug, diazepam, that targets the GABA

George T. Taylor, Sandra Lerch, Sabine Chourbaji

Acta Neurobiologiae Experimentalis , ISSUE 3, 254–260


C60 fullerenes increase the intensity of rotational movements in non-anesthetized hemiparkinsonic rats

TS. The effect of C60FAS on the development of general muscle fatigue in non-anesthetized animals has not yet been studied. It is known that animals with experimental hemiparkinsonism (EH) exhibit circular movements (Maisky et al., 2002; Talanov et al., 2017). We hypothesized that an EH animal model can be used to assess the development and modulation of skeletal muscle fatigue in non-anesthetized rats. That is, the i.p. injection of the dopamine (DA) receptor agonist apomorphine (AM), which

Andriy V. Maznychenko, Olena P. Mankivska, Inna V. Sokolowska (Vereshchaka), Bohdan S. Kopyak, Tomasz Tomiak, Nataliya V. Bulgakova, Olga O. Gonchar, Yuriy I. Prylutskyy, Uwe Ritter, Iryna V. Mishchenko, Alexander I. Kostyukov

Acta Neurobiologiae Experimentalis , ISSUE 1, 32–37

Research paper

Continuous MPTP intoxication in the Göttingen minipig results in chronic parkinsonian deficits

. Digital gait analysis, high performance liquid chromatography (HPLC) measurements and stereological counts of tyrosine hydroxylase-positive (TH+) neurons in the SNc revealed a dose-related decrease in gait velocity, striatal metabolite levels and neuron numbers with increasing doses of MPTP. No neuronal inclusions were observed, but alpha synuclein staining intensified with increased cumulative MPTP dosages. We conclude that this large-animal model of chronic MPTP administration in Göttingen minipigs

Mette Slot Nielsen, Andreas Nørgaard Glud, Arne Møller, Poul Mogensen, Dirk Bender, Jens Christian Sørensen, Doris Doudet, Carsten Reidies Bjarkam

Acta Neurobiologiae Experimentalis , ISSUE 3, 199–211

Research paper

Long-term behavioral, histological, biochemical and hematological evaluations of amyloid beta-induced Alzheimer’s disease in rat

Raheleh Kheirbakhsh, Mahnaz Haddadi, Ahad Muhammadnejad, Alireza Abdollahi, Farshad Shahi, Behzad Amanpour-Gharaei, Azadeh Abrahim-Habibi, Tahereh Barati, Saeid Amanpour

Acta Neurobiologiae Experimentalis , ISSUE 1, 51–59

Research paper

Effects of different delayed exercise regimens on cognitive performance in fimbria-fornix transected rats

Elise Wogensen, Linda Marschner, Marie Gajhede Gram, Siri Mehlsen, Valdemar H. B. Uhre, Pernille Bülow, Jesper Mogensen, Hana Malá

Acta Neurobiologiae Experimentalis , ISSUE 4, 323–336


Subchronic effects of ligands of cannabinoid receptors on learning and memory processes of olfactory bulbectomized rats

disease (AD) (Douma et al., 2011; Borre et al., 2012). OBX can be used as an animal model of AD because it produces some effects similar to AD-related symptoms and pathology (Aleksandrov et al., 2004; Yehuda and Rabinovitz, 2013; Franks et al., 2015). Behavioral abnormalities developed by the OBX rodents include hyperlocomotion, memory disturbances, reduced sexual activity, aggressive behavior, hyperemotionality. OBX rats display deficits in passive-avoidance test (Kelly et al., 1997) and impaired

Margarita Velikova, Dobrinka Doncheva, Roman Tashev

Acta Neurobiologiae Experimentalis , ISSUE 3, 286–296

Research paper

Aberrant changes of somatostatin and neuropeptide Y in brain of a genetic rat model for epilepsy: tremor rat

(TRM)is a genetic epileptic animal model which can manifest tonic convulsions without any external stimuli. The present study aimed to investigate the distribution and expression of SST and NPY in TRM brains, including hippocampus, temporal lobe cortex and cerebellum.Our RT‑PCR data showed that up‑regulated mRNA expression of SST and NPY was discovered in TRM hippocampus and temporal lobe cortex compared with control (Wistar) rats. The peptide levels of these neuropeptides in brain areas mentioned

Xiaoxue Xu, Feng Guo, Xinze Cai, Jun Yang, Jiuhan Zhao, Dongyu Min, Qianhui Wang, Liying Hao, Jiqun Cai

Acta Neurobiologiae Experimentalis , ISSUE 3, 165–175


Intracerebroventricular streptozotocin induces behavioral impairments and increases short-term C3 gene expression in the hippocampus of Wistar rats

factor C3 is a central component of the complement system and a key inflammatory protein activated in Alzheimer’s disease (Maier et al., 2008). Transgenic mouse is frequently used as a model to mimic familial AD symptoms and molecular aspects (Elder et al., 2010). Aiming to study the mechanisms associated with sporadic AD, an intracerebroventricular injection of streptozocin (icv-STZ) in rats has been consolidated as an animal model (Grünblatt et al., 2007; Grieb, 2016; Lester-Coll et al., 2006). STZ

Gabrielle Pfutzenreuter, Kenny Nieradka, Márcia Regina Pincerati, Ilton Santos da Silva

Acta Neurobiologiae Experimentalis , ISSUE 2, 160–169

Review Paper

The role of cannabinoids and endocannabinoid system in the treatment of epilepsy

Introduction. The treatment of epilepsy is still a major challenge. Despite the introduction of many new antiepileptic drugs, approximately 30% of patients still remain drug resistant. In the absence of a satisfactory therapy outcome, which is sometimes associated with numerous side effects, there is a need for new and effective drugs with low toxicity. Cannabinoids have been shown in preliminary animal model studies and in studies of patients with epilepsy to have antiepileptic activity. Aim

Monika Pędracka, Jacek Gawłowicz

Journal of Epileptology , ISSUE 2, 131–138

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