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case-report | 25-June-2021

A case series highlighting a common approach to identifying anti-Jk3

American descent; and anti-Jk3 among individuals of Finnish, Asian, and Polynesian descent.1,2 The Kidd system was first described in the 1950s, and there are currently four known phenotypes: Jk(a–b+), Jk(a+b–), Jk(a+b+), and Jk(a–b–).3 The Jk(a–b–) phenotype was first described by Pinkerton et al.4 in a Filipina individual in 1959. Jk(a–b–) is uncommon among individuals of European descent (p < 0.01) and is more common among individuals of Finnish, Asian, and Polynesian descent.1,2,3,5 Antibodies in

D.J.A.M. Talabong, W.E. Kelley

Immunohematology, Volume 37 , ISSUE 2, 84–88

Article | 09-November-2020

Anti-Jk3 with no clinical evidence of HDN

A sample was submitted to a reference lab from a 27-year-old Asian female, gravida 4 para 1, for antibody identification. Anti-Jk3 with an IgM component was identified. Subsequently, the antibody was eluted from the infant’s cord and venous red blood cells. Normal bilirubin and hematocrit levels ruled out hemolytic disease of the newborn (HDN). Anti-Jk3 has been implicated in two cases of mild HDN. In this case, this noncomplement-binding antibody caused a positive direct Coombs test

Celeste J. Hunter, Michael D. Ziebol

Immunohematology, Volume 13 , ISSUE 4, 136–137

Case report | 26-October-2019

Anti-Jk3 in a Filipino man

laboratory for further testing. Results from the reference lab testing revealed the presence of anti-Jk3 in the patient’s serum. The patient was placed on steroids, and his reticulocyte count increased with no further signs of extravascular hemolysis. No additional transfusions were necessary. He was eventually discharged with a hemoglobin of 13.6 g/dL. The purpose of this case study is to report the findings of an extremely rare but clinically significant antibody, anti-Jk3.

Shaina McCaskill, Scott Wise, Sheila Tinsley

Immunohematology, Volume 31 , ISSUE 3, 119–122

case-report | 30-September-2021

Development of anti-Jk3 associated with silenced Kidd antigen expression and a novel single nucleotide variant of the JK gene

within this system in clinical practice,3 infrequently, patients will manifest anti-Jk3, reflecting alloimmunization against the high-prevalence Jk3 antigen.2 From a patient/individual standpoint, although rare, such antibodies are most frequently encountered in those of Polynesian ancestry, but are also seen in other populations including those of Finnish ancestry, and are associated with a number of well-defined genetic variants in the JK alleles.4 We report a case of a Jknull phenotype with a

P.A. Manrai, A.J. Siddon, K.M. Hager, J.E. Hendrickson, M.A. Keller, C.A. Tormey

Immunohematology, Volume 37 , ISSUE 3, 109–112

Report | 20-March-2020

A simple screening assay for the most common JK*0 alleles revealed compound heterozygosity in Jk(a–b–) probands from Guam

The Jk(a–b–) phenotype results from alterations in the JK gene and is characterized by absence of the RBC urea transporter in the cell membrane. The frequency of Jk(a–b–) varies among populations, but this phenotype is most commonly found in people of Polynesian and Finnish descent. Although rare, Jk(a–b–) individuals present a clinical challenge because anti-Jk3 is produced readily in response to transfusion and pregnancy, and Jk(a–b–) blood is

Elisabet Sjöberg Wester, Julia Gustafsson, Beverly Snell, Peggy Spruell, Åsa Hellberg, Martin L. Olsson, Jill R. Storry

Immunohematology, Volume 25 , ISSUE 4, 165–169

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