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  • Acta Neurobiologiae Experimentalis

 

Original Paper

Additive interactions between retigabine and oxcarbazepine in the chimney test and the model of generalized tonic-clonic seizures in mice

performance) in adult male albino Swiss mice. Methods. Isobolographic analysis (type I) was applied to characterize interactions for the combination of RTG with OXC with respect to its anticonvulsant and acute side (neurotoxic) effects, as determined in the MES and chimney tests, respectively. Results. The combination of RTG with OXC at the fixed-ratios of 1:3, 1:1 and 3:1 produced additive interactions in the MES test in mice. Similarly, the combination of RTG with OXC at the fixed-ratio of 1:1 produced

Mirosław Zagaja, Barbara Miziak, Katarzyna Załuska, Paweł Marzęda, Bartłomiej Drop, Karolina Załuska-Patel, Grażyna Ossowska, Stanisław J. Czuczwar, Jarogniew J. Łuszczki

Journal of Epileptology , ISSUE 2, 87–94

Original Paper

Adenosine receptor agonists differentially affect the anticonvulsant action of carbamazepine and valproate against maximal electroshock test-induced seizures in mice

Background. Adenosine is regarded as an endogenous anticonvulsant and its agonists have been proved to affect the anticonvulsant activity of a number of antiepileptic drugs (AEDs) in animal models of seizures. Aim. To evaluate effects of adenosine agonists on carbamazepine (CBZ) and valproate (VPA) in mouse model of generalized tonic-clonic convulsions. Methods. The following adenosine receptor agonists were used: A 1 – cyclohexyladenosine, A2A – CGS 21 680, A3 – N6-benzyl

Mirosław Jasiński, Magdalena Chrościńska-Krawczyk, Stanisław J. Czuczwar

Journal of Epileptology , ISSUE 1-2, 21–29

Review Paper

Anticonvulsant therapy in brain-tumor related epilepsy

Walter Fröscher, Timo Kirschstein, Johannes Rösche

Journal of Epileptology , ISSUE 1, 41–56

research-article

Clinical characteristics of forced normalization and alternative psychosis with special consideration of the new anticonvulsants

“mental disturbances (mostly psychoses). The EEG-findings were reported only in 43 of the 66 patients. In 40 of these 43 patients, the clinical syndrome corresponded to both the AP and the FN concept; only in 3 patients the EEG findings remained unchanged during the period of mental disturbances compared to the period prior to these disturbances. MATERIAL AND METHODS For this update we conducted a literature research from 1987 (in this year a psychosis, triggered by the new anticonvulsant vigabatrin

Walter Fröscher, Volker Faust, Tilman Steinert

Journal of Epileptology , 7–13

research-paper

Protective effects of M8-B, a TRPM8 antagonist, on febrile- and pentylenetetrazol-induced seizures

seizure. In another part of the study, we aimed to evaluate the effect of M8-B on PTZ- and electroshock-induced seizures. The results showed that pretreatment with M8-B (9 mg/kg) increased the stage 2 and stage 4 latencies and attenuated stage 5 duration compared to the control group. This finding implies that M8-B exhibited a significant anticonvulsant effect in the PTZ-induced convulsion model. However, it did not produce such protective effects in the electroshock model. In agreement with our

Nazanin Zandi, Nosaibeh Riahi Zaniani, Ali Moghimi, Ali Roohbakhsh

Acta Neurobiologiae Experimentalis , ISSUE 1, 86–91

Research paper

Interaction between urethane and cannabinoid CB1 receptor agonist and antagonist in penicillin-induced epileptiform activity

intracerebroventricularly 30 minutes after the penicillin application in urethane-anesthetized and conscious animals. Urethane completely eliminated spontaneous ictal events in ECoG recordings and reduced the frequency and total amount of epileptiform activity. It did not alter either the proconvulsant effects of AM-251 or the anticonvulsant effects of ACEA on penicillin-induced epileptiform activity. The electrophysiological evidence suggests that there is no possible interaction between urethane and cannabinoid CB1

Gokhan Arslan, Sabiha Kubra Alici, Mustafa Ayyildiz, Erdal Agar

Acta Neurobiologiae Experimentalis , ISSUE 2, 128–136

review-article

Cannabinoids in the treatment of epilepsy – an updated review

disorders including epilepsy has been reviewed elsewhere (Ibeas Bih et al., 2015). It is believed that its anticonvulsant action of cannabidiol is associated with at least some of the following mechanisms: stimulation of 5-HT1a receptors, inhibition of glutamate release, inhibition of noradrenaline, dopamine and adenosine reuptake, stimulation of glycine receptors and stimulation and desensitization of transient receptor potential class channels (ankyrin and vanilloid types, i.e. TRPA1, TRPV1 and TRPV2

Marcin Kopka

Journal of Epileptology , 35–42

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