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review-article | 15-October-2020

Modulation of anxiety behavior in gonadectomized animals

INTRODUCTION Anxiety is a complex psychological process that often occurs after stressful life experiences. In a number of cases, it is adaptive since it prepares the organism for future stressful encounters. Nevertheless, if prolonged or exaggerated over time, anxiety induces many abnormal and maladaptive thoughts and behaviors (Leuner and Shors, 2012). Anxiety disorders are the most common of all psychiatric disorders; though, the current human and animal investigation has yet to provide a

Roghaieh Khakpay, Fatemeh Khakpai

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 3, 205–216

research-article | 18-March-2020

Parental internalizing symptoms as predictors of anxiety symptoms in clinic-referred children

Introduction Anxiety disorders are prevalent among children and may have long-term negative impact on individuals’ personal, social, and academic functioning (1). Several factors may influence the development and maintenance of anxiety in children, including genetic, physiological, temperamental, parental, and family-context related risks (2-4). Increased knowledge about factors that influence the level of anxiety symptoms in children is needed to improve clinical practice, as well as to

Krister Westlye Fjermestad, Christina Lium, Einar R. Heiervang, Odd E. Havik, Bente Storm Mowatt Haugland, Ingvar Bjelland, Gro Janne Henningsen Wergeland

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, Volume 8 , 18–24

Research paper | 04-May-2018

Effects of ascorbic acid on anxiety state and affect in a non-clinical sample

Objective Given that the literature data indicates that ascorbic acid may have an anxiolytic effect, we hypothesized that a single oral administration of ascorbic acid could acutely affect emotional states. Methods The effects of acid ascorbic supplementation on anxiety and other emotional states were evaluated by the State-Trait Anxiety Inventory (STAI), and Visual Analogue Mood Scale (VAMS). Immediately before, and 2 hours after receiving a single ascorbic acid dose (1000 mg) or placebo, 142

Bettina Moritz, Marcelo Liborio Schwarzbold, Ricardo Guarnieri, Alexandre Paim Diaz, Ana Lúcia S. Rodrigues, Alcir Luiz Dafre

Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 4, 362–372

Review Paper | 07-June-2016

Depression and anxiety in people with epilepsy: Why should we identify?

Introduction. People with epilepsy (PWE) have a higher risk of developing depression and anxiety than people without epilepsy. However, understanding and management of that issue remain under-recognized. Aim. To emphesize: a) the relationship between depression, anxiety, and epilepsy, and b) to suggest practical strategies for their identification by clinicians. Methods. The current literatures was reviewed investigating the impact of depression and anxiety in PWE and those examining the

Sung-Pa Park

Journal of Epileptology, Volume 24 , ISSUE 1, 57–62

Research Article | 30-November-2013

Exploring the Contribution of Parental Perceptions to Childhood Anxiety

Parental rearing practices such as over-involvement are associated with childhood anxiety; however, little is known about the contribution of parental perceptions to child anxiety. This study explores the relationship between maternal and paternal perceptions of parenting and childhood anxiety. The perceived rearing behaviors and parental sense of competence (i.e., satisfaction and efficacy) of the parents of anxious children (n = 59) were compared with those of a non-clinical control sample (n

Barbara H. Esbjørn, Ida D. Caspersen, Mikael J. Sømhovd, Sonja Breinholst, Marie Louise Reinholdt-Dunne

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, Volume 2 , ISSUE 3, 115–123

research-article | 25-March-2021

“Less stress”: a pilot study on a cognitive behavioral treatment program for anxiety in children with autism spectrum disorders

Introduction Autism spectrum disorders (ASD) are characterized by early-onset core difficulties in social- and communication skills and unusually restricted, repetitive behavior and interests with an estimated worldwide population prevalence of about 1%, affecting more males than females (1). Most children with ASD have one or more comorbid conditions like attention-deficit/hyperactivity disorder (ADHD), oppositional defiant disorder (ODD), anxiety- and mood disorders, implying a further

Beate Oerbeck, Kristin Romvig Overgaard, Tony Attwood, Jon Fauskanger Bjaastad

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, Volume 9 , 30–40

Research Article | 30-November-2015

Anxiety Disorders among Adolescents referred to General Psychiatry for Multiple Causes: Clinical Presentation, Prevalence, and Comorbidity

Reports of anxiety disorder characteristics among youth in clinical settings typically include descriptions of patients who have been specifically referred for anxiety treatment. At odds with a large body of evidence which demonstrates these disorders to be most common among young people, prevalence studies in samples referred to general psychiatry for multiple causes are scarce and report highly discrepant estimates.For this study and regardless of their presenting symptoms, 125 adolescents

Susanne Olofsdotter, Sofia Vadlin, Karin Sonnby, Tomas Furmark, Kent W. Nilsson

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, Volume 4 , ISSUE 2, 55–64

Research paper | 25-July-2017

EEG source activity during processing of neutral stimuli in subjects with anxiety disorders

Anxiety disorders are a social problem due to their prevalence and consequences. It is crucial to explore the influence of anxiety on cognitive processes. In this study we recorded EEG activity from 73 subjects (35 patients, 38 controls, matched for age and education)during performance of the Continuous Attention Task. We used low resolution electromagnetic tomography (LORETA) for evaluation of mechanisms of impaired cognitive performance in anxiety disorders. Analysis showed that

Bartłomiej Gmaj, Piotr Januszko, Jan Kamiński, Ewa Drozdowicz, Maciej Kopera, Dorota Wołyńczyk-Gmaj, Waldemar Szelenberger, Marcin Wojnar

Acta Neurobiologiae Experimentalis, Volume 76 , ISSUE 1, 75–85

research-article | 29-December-2021

Prevalence of elevated anxiety symptoms among children in quarantine with COVID-19 infection in the State of Qatar: A cross-sectional study

Introduction Worrying is considered a normal and adaptive component of emotional development in children. By the time they reach primary school, up to 70% of children report some kind of worrying (1). However, worrying can become pathological when excessive and persistent, and when it interferes with the child’s functioning (2). Such pathological worrying in children usually exists as part of an anxiety or mood disorder (3). Anxiety disorders are the most common mental disorders with onset

Yasser Saeed Khan, Abdul Waheed Khan, Islam Ahmed Noureldin Ahmed, Samar Hammoudeh, Halla Salim, Mohammed AbuKhattab, Muna A Rahman S Al-Maslamani, Abdulwahed Zainel, Sarah Nidal Salameh, Majid Alabdulla

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, Volume 9 , 187–195

research-article | 30-November-2018

The efficacy of manualized Cognitive Behavior Therapy conducted by student-therapists treating Danish youths with anxiety using a benchmark comparison

Introduction Anxiety disorders are some of the most common psychiatric disorders among children and adolescents (hereafter referred to as youths) (1,2). In an epidemiological meta-analysis, the prevalence for any anxiety disorder was found to be 12.3% among children (age 6-12 years old) and 11.0% for adolescents (age 13-18 years old) (1). In Denmark, the yearly number of youths diagnosed with depression or an anxiety disorder has tripled from 2006 to 2016 (3). Although many anxiety disorders

Daniel Bach Johnsen, Kristian Arendt, Mikael Thastum

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, Volume 7 , 68–80

research-article | 07-July-2020

Intracerebroventricular streptozotocin induces behavioral impairments and increases short-term C3 gene expression in the hippocampus of Wistar rats

INTRODUCTION Alzheimer’s disease (AD) is a progressive neurodegenerative disease which is clinically characterized by dementia and neurobehavioral impairments mainly on memory functions (Kar et al., 2004). Additionally, significant behavioral changes such as progressive memory loss, anxiety, agitation and irritability are observed. AD is categorized into two types: late-onset sporadic AD and early-onset familial AD (Dorszewska et al., 2016). The first one represents 95% of all the cases

Gabrielle Pfutzenreuter, Kenny Nieradka, Márcia Regina Pincerati, Ilton Santos da Silva

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 2, 160–169

Research paper | 06-February-2018

Further pharmacological characterization of eltoprazine: focus on its anxiolytic, anorexic, and adverse-effect potential

Eltoprazine, a drug that had previously been developed for aggression, has recently been investigated for L-DOPA-induced dyskinesia in animal models of Parkinson´s disease (PD) and in dyskinetic PD patients. Much less is known about effects of eltoprazine in other therapeutic indications. Indeed, the pharmacological profile of eltoprazine might suggest its effects on anxiety and food intake, but also adverse effect potential, which is the focus of the present study. Given for 2 weeks either as

Andreas Gravius, Andrzej Dekundy, Anita Vanaga, Lutz Franke, Wojciech Danysz

Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 1, 77–85

research-article | 31-July-2020

Aerobic exercise has an anxiolytic effect on streptozotocin-induced diabetic rats

, 2004). Diabetes has many complications including cardiomyopathy, retinopathy, neuropathy, nephropathy (American Diabetes Association, 2010), as well as affecting the mental status of the patients. Various psychological comorbidities, such as depression and anxiety, are associated with diabetes (Ducat et al., 2014) and the prognosis is worse in patients with poor glycemic control (Lustman et al., 2000). In addition to clinical studies, behavioral alterations were demonstrated in experimental models

Hasan Caliskan, Firat Akat, Goktug Omercioglu, Gulbahar Bastug, Hakan Ficicilar, Metin Bastug

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 3, 245–255

Research paper | 06-February-2018

Marble burying as compulsive behaviors in male and female mice

Marble burying is considered an, albeit controversial, animal model of the compulsive like behaviors of obsessive-compulsive disorder (OCD). Hallmark features of OCD patients are similarities and, more prominent, differences from anxiety disorders, e.g., the absence of sex differences and resistance to spontaneous remission. We report an experiment on marble burying by male and female C57/BL6/N mice. Animals were administered either the classic anxiolytic drug, diazepam, that targets the GABA

George T. Taylor, Sandra Lerch, Sabine Chourbaji

Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 3, 254–260

Research paper | 01-August-2017

Effects of social stress and clomipramine on emotional memory in mice

We have previously observed impairing effects of social defeat stress (CSDS) on inhibitory avoidance (IA) in mice. Given the similarity between changes produced by social stress in animals and symptoms of certain human psychopathologies such as depression and anxiety, the effects of the antidepressant clomipramine on IA impairment produced by CSDS were evaluated in the present study. Male CD1 mice were randomly assigned to the groups: non-stressed+saline, non-stressed+clomipramine, stressed

Aranzazu Duque, Concepción Vinader-Caerols, Santiago Monleón

Acta Neurobiologiae Experimentalis, Volume 76 , ISSUE 3, 225–233

Research paper | 15-January-2019

Detrimental effects of chia (Salvia hispanica L.) seeds on learning and memory in aluminum chloride-induced experimental Alzheimer’s disease

established (i.e., treatment). A battery of behavioral and cognitive tests were performed, including open-field, elevated plus maze, Porsolt’s forced swim, and Morris’ water maze, to evaluate anxietyand depression-like behaviors, and learning and memory. Results showed that chia supplementation was ineffective against Alzheimer’s-related anxiety, whereas depression-like behaviors were attenuated with both pretreatment and treatment. There was no improvement in learning and memory with chia treatment

Yasemin Bilgic, Enver Ahmet Demir, Nilufer Bilgic, Hatice Dogan, Okan Tutuk, Cemil Tumer

Acta Neurobiologiae Experimentalis, Volume 78 , ISSUE 4, 322–331

research-article | 30-November-2019

Physical activity and environmental enrichment: Behavioural effects of exposure to different housing conditions in mice

-Gresa et al., 2014). Marlau™ cages (MCs) were designed to standardize the stimulation of cognitive functions by exposing rodents to problem-solving opportunities during enrichment procedures that involve mazes and running wheels (Fares et al., 2012; Kentropp et al., 2018). In a prior study, it was reported that male Sprague-Dawley rats allocated to MCs displayed decreased anxiety-like behaviour in the elevated plus maze (EPM), enhanced performance in the Morris water maze, and stronger emotional

Raisa Rabadán, Marta Ramos-Campos, Rosa Redolat, Patricia Mesa-Gresa

Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 4, 374–385

short-report | 05-September-2020

Long-Term Evaluation of an Australian Peer Outdoor Support Therapy for Contemporary War Veterans

1. Introduction Each year in Australia, approximately 12,000 Australian Defence Force (ADF) personnel are deployed in military service (1). Mental health problems including Post-traumatic Stress Disorder (PTSD, i.e., a set of symptoms such as traumatic flashbacks, avoidance, feeling emotionally numb, negative thoughts and mood, and agitation) (1,2), anxiety (3) and depression (1) may develop in some personnel as a result of exposure to traumatic experiences during such service. In addition

S Cloete, L Chantler

Eat, Sleep, Work, Volume 3 , 39–53

research-article | 30-November-2020

Associations between insecure attachment styles to parents and suicidal ideation in adolescents with depression

ideation through their effects on self-esteem, emotion regulation, relationship functioning, and expectations for the future. Insecure attachment (high attachment anxiety and/or avoidance) is associated with a variety of ill effects on health, adjustment and well-being (26-29), and, importantly, increased risk of suicidal ideation (30). Specific subtypes of insecure attachment may lead to different developmental trajectories with specific risk profiles. Adolescents with avoidant attachment in relation

Luxsiya Waraan, Lars Mehlum, Erling W. Rognli, Nikolai O. Czajkowski, Marianne Aalberg

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, Volume 9 , 41–51

Research Article | 18-October-2018

Validity of the Brief Child and Family Phone Interview by comparison with Longitudinal Expert All Data diagnoses in outpatients

, oppositional defiant disorder, conduct disorder, separation anxiety disorder, generalized anxiety disorder, and major depressive disorder.Results:The criterion validity for BCFPI versus LEAD diagnoses was fair for oppositional defiant disorder (area under curve, 0.73), generalized anxiety disorder (0.73) and major depressive disorder (0.78), good for attention-deficit hyperactivity disorder (0.81) and conduct disorder (0.83), and excellent for separation anxiety disorder (0.90). The screening properties of

Markus Andersson, Martin Bäckström, Tord Ivarsson, Maria Råstam, Håkan Jarbin

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, Volume 6 , ISSUE 2, 83–90

research-article | 30-November-2021

Aligner treatment: patient experience and influencing factors

’ compliance, compromise the treatment result and discourage patients from wearing their appliances.11 Treatment experience and response to fixed appliances has been found to be complex,12 involving a variety of factors such as age, gender and type of appliance.13–15 Current patient experience of aligner treatment and its influencing factors, however, are still poorly understood.4,16,17 The aims of the present study were therefore to investigate patient experience (i.e., pain, anxiety and quality of life

Lin Xu, Hanshi Li, Li Mei, Yuan Li, Pokam Wo, Yu Li

Australasian Orthodontic Journal, Volume 38 , ISSUE 1, 88–95

Research Article | 23-January-2019

Psychiatric problems and quality of life in a clinical sample of adolescents: The role of peer relations

problems, with particular focus on symptoms of anxiety, depression, and ADHD. We also examined the potential mediating role of peer problems in the relationship between such symptoms and QoL.Methods:The sample consisted of 603 adolescents (ages 13-18) referred to clinical assessment. Psychiatric diagnoses according to the criteria of the International Statistical Classification of Diseases and Related Health Problems, 10th revision, were collected from participants’ clinical charts. Symptoms of

Ingunn Ranøyen, Eva Gulliksrud, Marit S. Indredavik, Frode Stenseng

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, Volume 6 , ISSUE 4, 183–192

research-article | 23-July-2021

Differences in affect integration in children with and without internalizing difficulties

Introduction Although internalizing disorders like anxiety and depression are among the highest contributors to disability and disease globally, there is a lack of progress in treatment options compared to somatic disorders (1). By identifying and understanding underlying dysfunctional processes, we can target interventions in a more focused and personalized way. Studies suggest that affect integration is implicated in psychopathology. As the development of affect integration starts in

Charlotte Fiskum, Tonje Grønning Andersen, Unni Tanum Johns, Karl Jacobsen

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, Volume 9 , 147–159

Research Article | 30-November-2013

Psychological Difficulties among Children and Adolescents with Ethnic Danish, Immigrant, and Refugee Backgrounds

This study investigated and compared the prevalence of psychological difficulties among Danish, immigrant, and refugee children.We enrolled 332 children between the ages of 8 and 18 years (148 Danish children, 81 immigrant children, and 67 children with refugee backgrounds), all from low-income areas of residence. The Health Behaviour in School-aged Children Symptoms Checklist, the Strengths and Difficulties Questionnaire, and the Revised Children’s Anxiety and Depression Scale were applied.We

Ingrid Leth, Janni Niclasen, Else Ryding, Yasmine Baroud, Barbara H. Esbjørn

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, Volume 2 , ISSUE 1, 29–37

research-article | 30-November-2020

Changes over time in mental health symptoms among adolescents in Tampere, Finland

include depression and anxiety (3). In externalizing disorders, the symptoms are directed towards the outside world, manifesting through unwanted behavior, such as conduct problems or delinquency (3). In scientific literature, eating disorders have either been classified under internalizing disorders or considered to form their own category outside the dichotomy (4). Similarly, substance abuse can be considered to constitute a category of its own or be classified under externalizing symptoms (5). The

Noora Knaappila, Mauri Marttunen, Sari Fröjd, Riittakerttu Kaltiala

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, Volume 9 , 96–104

research-paper | 14-June-2019

Antidepressant and anxiolytic efficacy of single, chronic and concomitant use of vortioxetine, dapoxetine and fluoxetine in prenatally stressed rats

INTRODUCTION Depression is one of the most common and most disabling mental disorders characterised by a major burden on both the patients and society as a whole. The most common symptoms of depression include low mood, low self-esteem, sleeping disorders and anxieties, which together frequently lead to suicides. It should be noted that the incidence of both (depression and anxiety disorders) have been on the rise, which may be related to longer lifespans, unemployment, migrations

Piotr Ratajczak, Krzysztof Kus, Tomasz Zaprutko, Mikołaj Szczepański, Sandra Rusowicz, Elżbieta Nowakowska

Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 1, 13–24

Research paper | 04-May-2018

Antimuscarinic-induced convulsions in fasted mice after food intake: no evidence of spontaneous seizures, behavioral changes or neuronal damage

Prolonged or repeated seizures have been shown to cause spontaneous recurrent seizures, increased anxiety-related behavior, locomotor hyperactivity, impaired functions of learning and memory, and neuronal damage in the hippocampus and other brain regions in animals. Mice and rats treated with antimuscarinic drugs after fasting for two days or less develop convulsions after being allowed to eat ad libitum. To address whether such behavioral and neuroanatomic changes occur following these

Nurhan Enginar, Asiye Nurten, Aslı Zengin Türkmen, Gül İpek Gündoğan, Zeynep Güneş Özünal

Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 4, 373–381

research-article | 30-November-2020

Psychiatric morbidity in children and adolescents with dermatological disorders

diagnostic criteria. Turkish adaptation, validity and reliability study of K-SADS-PL-T was made by Gökler et al. (10). Children’s Depression Inventory (CDI) CDI detects the level of depression in children (11) and was developed by Kovacs in 1981. The validity and reliability of the Turkish CDI version was performed by Oy in 1991 (12). This scale consists of 27 items. The score of each question varies between 0 and 2. A score of 19 and above is considered pathological. State-Trait Anxiety Inventory

Dilşad Yıldız Miniksar, Özlem Özel Özcan, Hülya Cenk, Yelda Kapıcıoğlu, Ayşegül Polat

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, Volume 9 , 1–8

research-paper | 30-November-2018

Prevention of cadmium-induced neurotoxicity in rats by essential nutrients present in nuts

light box (p<0.05) compared to control animals. Cadmium administration induced anxiogenic behavior as shown by significantly decreased latency (P<0.01) and time spent in the light box (P<0.01) when compared with control animals. The Alm+Cad group showed significantly increased latency (P<0.01) and time spent in light box (P<0.01) compared to cadmium-treated rats, indicating attenuation of cadmium-induced anxiety by almond supplementation. Fig. 3. Anxiety-like behavior was assessed by using a light

Zehra Batool, Faiza Agha, Saiqa Tabassum, Tuba Sharf1 Batool, Rafat Ali Siddiqui, Saida Haider

Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 2, 169–183

Research Article | 30-November-2014

The Use of Social Networking Sites by Adolescents with Psychiatric Illnesses: A Qualitative Study

” feelings of distress without forcing any specific person into a supportive discussion. In addition, SNSs were described as lower-stress means of communication that allowed responses to be carefully formulated; this led to participants sharing information that they would not have shared during face-to-face interactions. However, participants also described anxiety surrounding the pressure to be active on SNSs, and they found it stressful to be exposed to pictures and posts involving former romantic

Gerrit Ian van Schalkwyk, Katherine Klingensmith, Paige McLaughlin, Zheala Qayyum

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, Volume 3 , ISSUE 2, 108–114

Research Article | 22-May-2019


In recent years, the incoming information about the emergence of new superbacteria and superviruses has been causing growing anxiety. However, also fungi are with increasing frequency reported as the sources of intercontinental microbiological hazards. According to the latest reports, quickly spreading, multidrug-resistant and difficult to identify yeast Candida auris may soon become the center of attention for clinicians, laboratory diagnosticians and the groups of advisers on the hospital

Dominika Grondalska, Wioletta Kmieciak

Postępy Mikrobiologii - Advancements of Microbiology, Volume 56 , ISSUE 3, 282–288

Research Article | 10-July-2018

Development of a Shortened Version of the Adolescent Stress Questionnaire (ASQ-S): construct validity and sex invariance in a large sample of Swedish adolescents

, anxiety and worry and negatively with self-esteem. Girls reported higher stress levels than boys in eight of the nine scales. Stressors related to peer pressure predicted reported levels of anxiety and worry one year later, whereas stressors related to romantic relationships predicted depressive symptoms.Conclusions:Overall this study suggests that the ASQ-S could be a valid measure of adolescent stressor experience and psychometrically equivalent to the full ASQ-2.

Malin K. Anniko, Katja Boersma, Nikil Ph. L. van Wijk, Don Byrne, Maria Tillfors

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, Volume 6 , ISSUE 1, 4–15

Article | 28-August-2018


Visual pollution in the urban facade is one of the causes of distress and anxiety in today’s cities. The purpose of this research is to achieve disruption and tranquility causing factors in new and old facades in Jolfa district of Isfahan and finally preparing design tips of a safe, relaxing and without visual pollution facade. Therefore, archival and field work documentation has been analyzed and according to the statistical with SPSS 20 software investigated correlation between variables. The


Architecture, Civil Engineering, Environment, Volume 10 , ISSUE 3, 57–70

Article | 10-November-2020

Leukocyte reduction of red cells when transfusing patients with autoimmune hemolytic anemia: a strategy to decrease the incidence of confounding transfusion reactions

Autoimmune hemolytic anemia (AIHA) presents a difficult challenge to clinicians and blood bankers alike. Autoantibodies in the serum significantly complicate serologic evaluation, and necessitate performing procedures such as adsorptions to eliminate the possibility of underlying alloantibodies. In many instances the blood that is issued may be phenotypically similar but remains crossmatch incompatible, generating a considerable degree of anxiety among the clinical staff who are responsible for

Jeanne A. Lumadue, Rosetta Sue Shirey, Thomas S. Kickler, Paul M. Ness

Immunohematology, Volume 12 , ISSUE 2, 84–86

Case report | 09-October-2019

Hemolytic transfusion reaction attributable to anti-Dia  

(RBCs) in the apheresis unit as part of her regular treatment. When the patient started receiving the implicated unit, she reported back pain, chest pain, and a feeling of anxiety, suggestive of an acute transfusion reaction. The transfusion was ceased and an investigation of an adverse event was commenced. This case illustrates that the presence of antibodies to low-prevalence antigens remains a significant issue for transfusion-dependent individuals. To prevent other transfusion reactions by anti

Arthur J. Joyce, Kelli M Quantock, Ray Banh, Yew-Wah Liew

Immunohematology, Volume 33 , ISSUE 1, 6–8

Review | 25-July-2017

Lithium – therapeutic tool endowed with multiple beneficiary effects caused by multiple mechanisms

Mood disorders are relatively common serious human diseases for which there is often no ideal pharmacotherapy. Basic characteristic of these diseases is affective disorder shifting the mood of the patient to depression (together with anxiety or not) or towards to euphoria. Available drugs are usually divided into two groups – mood stabilizers, which are used primarily to treat bipolar disorder,and antidepressants for the treatment of unipolar depression. Lithium is still recommended as the

Miroslava Vosahlikova, Petr Svoboda

Acta Neurobiologiae Experimentalis, Volume 76 , ISSUE 1, 1–19

research-article | 15-October-2020

Subchronic effects of ligands of cannabinoid receptors on learning and memory processes of olfactory bulbectomized rats

INTRODUCTION Endocannabinoid system (ECS) plays role in many physiological processes, including mood, learning and memory. It is also involved in the pathogenesis of anxiety and mood disorders, as well as neurodegenerative disorders (Hill and Gorzalka, 2009; Ranieri et al., 2016). ECS consists of the endogenous cannabinoids (endocannabinoids), cannabinoid receptors and the enzymes that synthesize and degrade endocannabinoids. The cannabinoid receptors (CB1 and CB2) belong to the class of G

Margarita Velikova, Dobrinka Doncheva, Roman Tashev

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 3, 286–296

research-article | 30-November-2019

Effects of HTR1A rs6295 polymorphism on emotional attentional blink

INTRODUCTION As we are constantly bombarded with emotionally loaded sensory information, coping with emotionally adverse environmental influences is key to establishing a healthy mental life. Psychological vulnerabilities emerge when emotion regulation mechanisms have become disturbed or are suboptimal due to one’s life experience and/or unfavourable genetic predispositions, often leading to neuropsychiatric disorders, such as depression, anxiety or even psychosis (Zilverstand et al., 2017). A

Kadi Tulver, Madis Bachmann, Mariliis Vaht, Jaanus Harro, Talis Bachmann

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 4, 389–399

review-paper | 23-March-2020

Pharmacological and non-pharmacological approaches to life threatening conditions in epilepsy

seizures, multiple drug therapy and frequent changes of pharmacotherapy, excessive use of alcohol, frontal lobe epilepsy, mental dysfunctions, co-occurring anxiety and depression disorders, and using lamotrigine (women in particular) (Tomson, 2000; Tomson et al., 2005; Hesdorffer, Tomson, 2013; Tomson et al., 2013; Holst et al., 2013; Granbichler et al., 2015; Tomson et al., 2016). According to Walczak (2003), the results of most studies have not revealed a relationship between any AED and SUDEP. There

Barbara Błaszczyk, Aleksandra Walczak, Natalia Ścirka, Agnieszka Konarzewska, Barbara Miziak, Stanisław J. Czuczwar

Journal of Epileptology, Volume 28 , 43–54

research-article | 22-November-2018

The potential mechanisms of effect of valproic acid on lipid profiles: an updated review

INTRODUCTION Valproic acid (2-propylpentanoic acid) is a branched-short-chain fatty acid derived from valeric acid which is extracted from Valeriana officinalis (Fan et al., 2016; Tomson et al., 2016). Valproic acid is commonly used for the treatment of epilepsy, psychiatric disorders such as bipolar disorder and anxiety and prophylaxis of a migraine (Ghodke-Puranik et al., 2013; Terbach and Williams, 2009; Tseng et al., 2017). Valproic acid is well absorbed and has a very high ability to bind

Santoso Jaeri, Wardah Rahmatul Islamiyah

Journal of Epileptology, Volume 26 , ISSUE 1-2, 49–54

critical-appraisal | 31-March-2020

A brief update on psychogenic non-epileptic seizures: a challenge to overcome

exist on the role of single signs or symptoms in confirming or excluding PNES, as sensitivity and specificity are generally suboptimal. Prolactin and creatinkinase are reliable serum biomarkers, as normal values within a few hours after an episode may help confirm the diagnosis of PNES. However, the sole normality of these levels does not exclude the diagnosis of ES. Many psychiatric conditions are common in people with PNES, including depression, anxiety, post-traumatic stress disorders

Massimiliano Beghi, Cesare Maria Cornaggia, Ettore Beghi

Journal of Epileptology, Volume 28 , 67–72

research-article | 29-October-2021

The Road Less Travelled: Identifying Support Needs in Lewy Body Dementia

Madelaine B. Rañola

Australasian Journal of Neuroscience, Volume 31 , ISSUE 2, 27–31

Research Article | 30-November-2015

A Danish study of One-session Treatment for Specific Phobias in Children and Adolescents

One-session treatment (OST) is a short-term massed exposure therapy for the treatment of specific phobias in children and adults. Systematic reviews have demonstrated the effectiveness of the treatment for children and adolescents across countries and age groups.A single-group open trial design was used to examine the feasibility and preliminary efficacy of OST for youths with specific phobias in a Danish context.At the Anxiety Clinic of Aarhus University, 10 youths between the ages of 7 and 17

Mette Djernes Nielsen, Christina Linddahl Andreasen, Mikael Thastum

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, Volume 4 , ISSUE 2, 65–76

Case report | 18-October-2018

Widespread cortical PET abnormalities in an adolescent related to a PNES dissociative state, PTSD, ADHD, and domestic violence exposure

violence exposure.Methods:Detailed psychiatric and neuropsychological assessment was performed initially, followed by a PET study. The PET imaging was carried out in the resting-state and in the dissociative-state.Results:The adolescent was suffering from multiple episodes of unconsciousness, all found to be psychogenic; thus, PNES was diagnosed. However, at the psychopathology symptom level, the adolescent had heightened impulsivity, hyperactivity, hyperarousal, anxiety, somatic, and dissociative

Dejan Stevanovic, Leposava Brajkovic, Madhur Kumar Srivastava, Ivan Krgovic, Jasna Jancic

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, Volume 6 , ISSUE 2, 98–106

book-review | 19-August-2019

Validation of the Diagnostic Infant and Preschool Assessment in a Danish, trauma-exposed sample of young children

and research on age-appropriate adaptations and validation of disorders for infants, toddlers and preschool-aged children are increasing (14, 15). Emerging evidence (12, 16, 17) has shown that comorbid disorders such as oppositional defiant disorder (ODD), major depressive disorder (MDD), and separation anxiety disorder (SAD) among preschool children with PTSD are common, just as it has been demonstrated in studies with older children. Therefore, it is of the most importance that assessment of

Sille Schandorph Løkkegaard, Mette Elmose, Ask Elklit

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, Volume 7 , 39–51

Research Article | 30-November-2013

Underidentification of Autism Spectrum Disorder in Females: A Case Series Illustrating the Unique Presentation of this Disorder in Young Women

(insistence on sameness, lack of social engagement, and social processing difficulties); 2) heightened psychiatric comorbidities with internalizing disorders (anxiety, depression, and borderline personality traits); and 3) emotional dysregulation. These three domains reflect specific processes that may help to explain the underidentification of ASD in females via diagnostic overshadowing.Consideration of atypical symptom presentations, heightened comorbidities, and emotion regulation difficulties may help

Andrea Trubanova, Katharine Donlon, Nicole L. Kreiser, Thomas H. Ollendick, Susan W. White

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, Volume 2 , ISSUE 2, 66–76

research-article | 18-July-2020

Psychometric validity of the Compassionate Engagement and Action Scale for Adolescents: a Swedish version

), investigated how adolescents receive and give compassion (18). Neff’s construct of self-compassion has been shown to be associated with adolescent psychopathology (6, 9, 19-21). Difficulties in generating and experiencing compassion and caring are associated with psychiatric symptoms for adolescents such as depressive symptoms (correlations between .60 to .62) (6, 9, 19), suicidality (compassion explained 3.4% variance in suicidality) (20), and anxiety (correlations between .26 to .73) (9, 21). From a

Eva Henje, Frida Carlberg Rindestig, Paul Gilbert, Inga Dennhag

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, Volume 8 , 70–80

research-article | 30-November-2020

Salvia divinorum increases alcohol intake and tonic immobility whilst decreasing food intake in Wistar rats

response to cocaine, ethanol, phencyclidine, saccharin, and food in a dose-dependent manner (Crosgrove and Carroll, 2002). The activation of the dynorphin/KOP system has also been shown to be necessary for stress-induced behavioral responses in animal models of anxiety, depression, and drug-seeking behaviors (Bruchas et al., 2010). The cataleptic immobility, or catalepsy, can be defined as a failure to correct externally imposed “awkward postures”, whereas tonic immobility (TI) is a reversible state of

Priscila Vázquez-León, Ulises Arenas-Martínez, Dafne Córdova-Maqueda, Tomás Fregoso-Aguilar, Eduardo Ramírez-San Juan, Abraham Miranda-Páez

Acta Neurobiologiae Experimentalis, Volume 81 , ISSUE 1, 34–42

Research Article | 30-November-2013

Risk factors for suicide attempts in the total population of Faroese eighth graders

28 % were boys and 72 % were girls. In line with the expectations, the initial comparison showed that adolescents reporting life-time suicide attempt had significantly higher scores on attachment anxiety and negative affectivity, and had significantly lower scores on attachment closeness, and both past and present social support. Further analyses stratified on gender, however, revealed unexpected results, as a high score on negative affectivity only was a significant risk factor for life-time

Tóra Petersen, Ask Elklit

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, Volume 2 , ISSUE 3, 106–114

research-article | 06-June-2019

Further evidence of the Diagnostic Utility of the Child Behavior Checklist for identifying pediatric Bipolar I Disorder

diagnostic aid is the Child Behavior Checklist (CBCL) (8). The CBCL is an empirically derived broadband assessment tool of psychopathology with excellent psychometric properties that has been translated into over 100 languages and is an easy to use paper and pencil instrument. A body of research (9–12) and a meta-analysis (13) have shown very high correspondence between a unique profile of the CBCL consisting of elevations in the Attention, Anxiety/Depression and Aggression subscales greater than two

Amy Yule, Maura Fitzgerald, Timothy Wilens, Janet Wozniak, K. Yvonne Woodworth, Alexa Pulli, Mai Uchida, Stephen V. Faraone, Joseph Biederman

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology , Volume 7 , 1–8

review-paper | 11-February-2020

Clinical characteristics of forced normalization and alternative psychosis with special consideration of the new anticonvulsants

; significant mood change, hypomania/mania or depression; anxiety with depersonalization, derealization; hysteria), with concomitant reduction of epileptic activity in the EEG, and/or complete cessation of clinical seizures for at least 1 week. The expected EEG changes are very detailed (reduction in the total number of spikes counted in a 60-min. awake EEG recording by over 50% compared to a similar recording performed during a normal state of behavior and others. However, other EEG findings than spikes

Walter Fröscher, Volker Faust, Tilman Steinert

Journal of Epileptology, Volume 28 , 35–41

Research Article | 30-November-2013

Latent Classes of Symptoms related to Clinically Depressed Mood in Adolescents

diverse symptomatology, including vegetative symptoms, suicidal ideation, anxiety, conduct problems, body dysmorphic symptoms, and deliberate vomiting. The classes predicted functional impairment in that the members of the second class showed more functional impairment.The relatively small sample size limited the generalizability of the results of this study, and the amount of items included in the analysis was restricted by the rules of latent class analysis. No conclusions about gender differences

Eva Henje Blom, Mats Forsman, Tony T. Yang, Eva Serlachius, Jan-Olov Larsson

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, Volume 2 , ISSUE 1, 19–28

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