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Research paper

AUGMENTED REALITY GAME THERAPY FOR CHILDREN WITH AUTISM SPECTRUM DISORDER

This paper presents progress on treating children with Autism Spectrum Disorder (ASD) using Augmented Reality based games. The aim of these games is to enhance social interaction and hand-eye coordination in children with ASD thus easing them into becoming more comfortable around unfamiliar people. Colour detection and tracking and motion tracking concepts in augmented reality have been used to develop games for young children with ASD. The idea is that these games will encourage concentration

S.K. Bhatt, N.I. De Leon, Adel Al-Jumaily

International Journal on Smart Sensing and Intelligent Systems , ISSUE 2, 519–536

research-paper

Autism spectrum disorder and mercury toxicity: use of genomic and epigenetic methods to solve the etiologic puzzle

INTRODUCTION Autism spectrum disorder (ASD) is an increasingly prevalent neurodevelopmental condition of unknown etiology. Importantly, reported manifestations of low-level exposure to mercury, a highly neurotoxic heavy metal, are similar to those of ASD. In the past several years, evidence has accumulated linking the risk of toxic manifestations of low-level mercury exposure to particular genes, mutations, and epigenetic changes. The fields of genomics, genetics, and epigenetics are rapidly

Mark E. McCaulley

Acta Neurobiologiae Experimentalis , ISSUE 2, 113–125

Research Article

Underidentification of Autism Spectrum Disorder in Females: A Case Series Illustrating the Unique Presentation of this Disorder in Young Women

Autism spectrum disorder (ASD) is diagnosed more often in males than females, with the male-to-female gender ratio reported to be around 4.3:1 to 5:1. It is possible that the underrecognition of ASD in females partially contributes to this uneven ratio. Recent attention has been placed on understanding the processes that give rise to this gender difference in ASD prevalence. Socialization may contribute to the unique presentation of ASD in females, which may underlie this condition’s subsequent

Andrea Trubanova, Katharine Donlon, Nicole L. Kreiser, Thomas H. Ollendick, Susan W. White

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology , ISSUE 2, 66–76

Review

A Systematic Review of Social Communication and Interaction Interventions for Patients with Autism Spectrum Disorder

Autism spectrum disorder (ASD) is currently not curable, but it may be malleable to varying degrees in response to different interventions to improve outcomes.We conducted a systematic review of interventions aimed at ameliorating social communication impairments in patients with ASD. This study was registered in the International Prospective Register of Systematic Reviews (no. CRD42013003780).We focused on the ASD interventions that are frequently applied in Swedish clincial practice to

Tatja Hirvikoski, Ulf Jonsson, Linda Halldner, Aiko Lundequist, Elles de Schipper, Viviann Nordin, Sven Bölte

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology , ISSUE 3, 147–168

Research Article

Cross-Cultural Adaptation of the KONTAKT Social Skills Group Training Program for Children and Adolescents with high-functioning Autism Spectrum Disorder: A feasibility Study

Social skills group training is an intervention method that has demonstrated moderate evidence of improvement among children and adolescents with autism spectrum disorder (ASD). KONTAKT is a manualized social skills group training program that was developed in Germany and that has demonstrated preliminary evidence of positive effect. In this study, we describe its adaptation to Scandinavian settings.The aim of this study was to evaluate the clinical feasibility of the Swedish version of KONTAKT

Nora Choque Olsson, Agneta Karlsson, Sofia Andersson, Annie Boström, Mari Ljungström, Sven Bölte

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology , ISSUE 2, 46–54

Review

Immune dysfunction and neuroinflammation in autism spectrum disorder

Autism spectrum disorder (ASD) is a complex heterogeneous neurodevelopmental disorder with a complex pathogenesis. Many studies over the last four decades have recognized altered immune responses among individuals diagnosed with ASD. The purpose of this critical and comprehensive review is to examine the hypothesis that immune dysfunction is frequently present in those with ASD. It was found that often individuals diagnosed with ASD have alterations in immune cells such as T cells, B cells

Geir Bjørklund, Khaled Saad, Salvatore Chirumbolo, Janet K. Kern, David A. Geier, Mark R. Geier, Mauricio A. Urbina

Acta Neurobiologiae Experimentalis , ISSUE 4, 257–268

Research Article

An exploration of the experience of parents with children with autism spectrum disorder after diagnosis and intervention

Delays and difficulties in both diagnosis and access to services can compound existing stressors experienced by families with children with autism spectrum disorder. Early and accurate diagnosis and appropriate intervention may not only improve child-specific outcomes but may also mitigate some of the stressors impacting family relationships and quality of life. We aimed to understand the experience of over 500 families that had sought autism spectrum disorder diagnosis and intervention, their

Ben Milbourn, Marita Falkmer, Melissa H. Black, Sonya Girdler, Torbjorn Falkmer, Chiara Horlin

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology , ISSUE 3, 104–110

Research Article

The Early Diagnosis of Preschool Children with Autism Spectrum Disorder in Norway: a Study of Diagnostic Age and Its Associated Factors

The early identification of autism spectrum disorder is important to ensure access to early intervention. Much research has focused on the identification of early behavioral symptoms and screening. This study examines referral for diagnostic assessment, diagnostic age, and factors associated with diagnostic age for children with autism spectrum disorder. The results of this study indicate that children are referred and diagnosed later than they should be. Previous research has identified a

Kenneth Larsen

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology , ISSUE 2, 136–145

Review

Cerebral hypoperfusion in autism spectrum disorder

Cerebral hypoperfusion, or insufficient blood flow in the brain, occurs in many areas of the brain in patients diagnosed with autism spectrum disorder (ASD). Hypoperfusion was demonstrated in the brains of individuals with ASD when compared to normal healthy control brains either using positron emission tomography (PET) or single-photon emission computed tomography (SPECT). The affected areas include, but are not limited to the: prefrontal, frontal, temporal, occipital, and parietal cortices

Geir Bjørklund, Janet K. Kern, Mauricio A. Urbina, Khaled Saad, Amira A. El-Houfey, David A. Geier, Salvatore Chirumbolo, Mark R. Geier, Jyutika A. Mehta, Jan Aaseth

Acta Neurobiologiae Experimentalis , ISSUE 1, 21–29

research-article

The use of wearable technology to measure and support abilities, disabilities and functional skills in autistic youth: a scoping review

conditions (3). Unlike traditional methods of monitoring physiological activity and behavior, WTs have the potential to provide real-time and objective measures of activity during day to day life (3, 4). These technologies may show promise in expanding opportunities to improve understanding of clinical conditions and through providing a means to continuously measure and monitor daily life functioning, may contribute novel individualized intervention and treatment (4, 5). Autism Spectrum Disorder (ASD) is

Melissa H. Black, Benjamin Milbourn, Nigel T. M. Chen, Sarah McGarry, Fatema Wali, Armilda S. V. Ho, Mika Lee, Sven Bölte, Torbjorn Falkmer, Sonya Girdler

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology , 48–69

Research paper

Face processing in a case of high functioning autism with developmental prosopagnosia

The ability to “read” the information about facial identity, expressed emotions, and intentions is crucial for non-verbal social interaction. Neuroimaging and clinical studies consequently link face perception with fusiform gyrus (FG) and occipital face area (OFA) activity. Here we investigated face processing in an adult, patient PK, diagnosed with both high functioning autism spectrum disorder (ASD) and developmental prosopagnosia (DP). Both disorders have a significant impact on face

Hanna B. Cygan, Hanna Okuniewska, Katarzyna Jednoróg, Artur Marchewka, Marek Wypych, Anna Nowicka

Acta Neurobiologiae Experimentalis , ISSUE 2, 114–131

research-article

A ten year longitudinal examination of the incidence rate and age of childhood encephalopathy diagnoses in an autism spectrum disorder diagnosed cohort

INTRODUCTION Autism spectrum disorder (ASD) is defined by persistent deficits in social communication and social interaction, and restricted, repetitive patterns of behavior, interests, or activities (American Psychiatric Association, 2013). Although an ASD diagnosis is defined behaviorally by the American Psychiatric Association (APA), other features, more physical or health related, are associated with an ASD diagnosis (Geier et al., 2012; Kern et al., 2014a). Among the most common are

Janet K. Kern, David A. Geier, Kristin G. Homme, Mark R. Geier

Acta Neurobiologiae Experimentalis , ISSUE 1, 66–75

Research Article

Familiality of Quantitative Autism Traits

Autistic traits exist along a continuum that extends into social functioning in the general population, and they aggregate in the family members of children with autism spectrum disorder (ASD). Quantitative measures are therefore essential when investigating the patterns of familiality of these traits. Prior studies have suggested differential inheritance patterns of autistic traits that depend on the cognitive level of the child with ASD as well as the family type.Our goal was to examine the

Katja Jussila, Kristen Lyall, Sanna Kuusikko-Gauffin, Marja-Leena Mattila, Rachel Pollock-Wurman, Tuula Hurtig, Leena Joskitt, Risto Bloigu, Hanna Ebeling, Irma Moilanen, David Pauls

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology , ISSUE 2, 126–135

Research Article

Emotion recognition from the eye region in children with and without Autism Spectrum Disorder in Arab and Scandinavian countries

Background:Difficulties in facial emotion recognition (ER) skills are linked to autism spectrum disorder (ASD) in studies performed in Western and Eastern Asian countries. However, there is a paucity of research examining ER skills in Arab countries, where face-covering veils are more common than in Western countries.Objective:Our aim was to examine basic ER and ER error patterns in Egyptian and Finnish children with and without ASD.Method:We employed the eye-submodule of the Frankfurt Test and

Sanna Kuusikko-Gauffin, Sherin Elsheikh, Sven Bölte, Manal Omar, Geylan Riad, Hanna Ebeling, Arja Rautio, Irma Moilanen

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology , ISSUE 4, 159–169

Review

Developmental neurotoxicants and the vulnerable male brain: a systematic review of suspected neurotoxicants that disproportionally affect males

The prevalence of neurodevelopmental disorders (NDs), including autism spectrum disorder, attention-deficit/hyperactivity disorder, tic disorder, obsessive-compulsive disorder, and emotional disturbances, has increased notably in the past few decades. To date, debate continues as to the origins of NDs. Increases in widespread exposure to and bioaccumulation of chemical neurotoxicants have paralleled the upsurge in NDs, and are suggested to be causal agents for NDs. One consistent aspect of NDs

Janet K. Kern, David A. Geier, Kristin G. Homme, Paul G. King, Geir Bjørklund, Salvatore Chirumbolo, Mark R. Geier

Acta Neurobiologiae Experimentalis , ISSUE 4, 269–296

Editorial

Special Issue on the Topic of Autism Spectrum Disorder

Angela M. Reiersen, Sven Bölte

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology , ISSUE 2, 52–54

Commentary

A conceptual framework for understanding characteristics of self-awareness associated with autism spectrum disorder

Mette Elmose

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology , ISSUE 3, 109–114

research-article

Transitivity Types Predict Communicative Abilities in Infants at Risk of Autism*

instances when caregivers name objects for infants, encourage their infants to play with an object, or simply shift their attention between infant and object. The current research analyzes instances of joint attention and bridging behaviors as they occur dynamically in real time and across months with respect to communicative development. Transitivity and Joint Attention The study of joint attention has been especially prevalent as it pertains to Autism Spectrum Disorder (ASD) (Bruinsma et al., 2004

Rebekka Schleier, Jana M. Iverson, Andrew P. King, Meredith J. West

Journal of Social Structure , ISSUE 3, 119–139

research-article

Putative shared mechanisms in autism spectrum disorders and attention deficit hyperactivity disorder, a systematic review of the role of oxidative stress

: autism spectrum disorder; BA22: Brodmann area 22; BDNF: brain-derived neurotrophic factor; BSID-II: Bayley scales for infant development-II; CARS: Childhood autism rating scale; CAT: catalase activity; DSM-IV: Diagnostic and Statistical Manual of Mental Disorders-IV; DSM-IV-TR: Diagnostic and Statistical Manual of Mental Disorders-IV text revision; F2-IsoPs: F2-Isoprostanes; GSH: reduced glutathione; GSH-Px: glutathione peroxidase; GSSG: glutathione dissulfide; GSSH: glutathione persulfide; LHP

Filipa Sa-Carneiro, Conceição Calhau, Rui Coelho, Margarida Figueiredo-Braga

Acta Neurobiologiae Experimentalis , ISSUE 2, 129–138

Research Article

How do Girls with Low Functioning Autism Compare to Boys with Autism and Typically Developing Girls with regard to Behavior, Cognition, and Psychopathology?

The female autism spectrum disorder (ASD) phenotype is currently underresearched. Girls with ASD may differ from boys with ASD, yet few studies have tested this hypothesis, particularly among low functioning individuals. This study compared girls and boys with predominantly low functioning ASD and typically developing girls during middle and late childhood across autism symptoms, cognition, sensory overresponsivity, and co-occurring psychopathology.Three mental-age–matched groups were compared

Camilla Nguyen, Angelica Ronald

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology , ISSUE 2, 55–65

Research Article

Participation profiles and the barriers and facilitators that impact on participation of children with Autism Spectrum Disorders living in regional and remote Western Australia

Background: Autism Spectrum Disorder (ASD) is a heterogeneous condition, influencing participation in activity and occupation. Approximately, 1% of Australian children have an ASD diagnosis, with many of these families living in remote and regional areas. Given the environments role in facilitating or hindering participation, there is a need to understand how geographical location impacts the participation profiles of children with ASD. Objective: This study aims to describe the participation

Shani Mattinson, Marita Falkmer, Melissa H Black, Sonya Girdler

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology , ISSUE 4, 170–182

Clinical Practice

Toward a new generation of quality registries for neurodevelopmental disorders: the example of NEUROPSYK

adequate follow-up related to the implementation of existing regional and national guidelines for assessment and treatment; 2) providing clinical decision-making aids; and 3) conducting large-scale clinical epidemiological research. The registry incorporates all legal requirements for quality registries in Sweden.NEUROPSYK includes patients of all ages diagnosed with NDDs per the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. These diagnoses include autism spectrum disorder

Anna Löfgren Wilteus, Frida Bartonek, Jacqueline Borg, Sven Bölte

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology , ISSUE 3, 141–146

Research Article

Attention-Deficit/Hyperactivity Disorder, Autistic Traits, and Substance Use Among Missouri Adolescents

Although existing literature demonstrates the association of attention-deficit/hyperactivity disorder (ADHD) with both substance use (SU) and autism spectrum disorder (ASD), few studies have examined rates of SU among adolescents with elevated ASD symptoms, with or without comorbid ADHD. Clinic-based studies suggest a possible protective effect of ASD against SU, but this has not been confirmed in population-based studies.We examined alcohol, tobacco, and drug use in adolescents with either

Richard C. Mulligan, Angela M. Reiersen, Alexandre A. Todorov

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology , ISSUE 2, 86–92

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