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Review

Lithium – therapeutic tool endowed with multiple beneficiary effects caused by multiple mechanisms

Mood disorders are relatively common serious human diseases for which there is often no ideal pharmacotherapy. Basic characteristic of these diseases is affective disorder shifting the mood of the patient to depression (together with anxiety or not) or towards to euphoria. Available drugs are usually divided into two groups – mood stabilizers, which are used primarily to treat bipolar disorder,and antidepressants for the treatment of unipolar depression. Lithium is still recommended as the

Miroslava Vosahlikova, Petr Svoboda

Acta Neurobiologiae Experimentalis , ISSUE 1, 1–19

Research paper

The effects of edaravone in ketamine-induced model of mania in rats

Bipolar disorder is a chronic disease characterized by recurring episodes of mania and depression that can lead to disability. This study investigates the protective effects of edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a drug with well-known antioxidant properties, in a model of mania induced by ketamine in rats. Locomotor activity was assessed in the open-field test. Superoxide dismutase (SOD), catalase (CAT) and thiobarbituric acid reactive substances (TBARS) levels were measured in

Filiz Civil Arslan, Ahmet Tiryaki, Mehmet Yıldırım, Evrim Özkorumak, Ahmet Alver, İlkay Keleş Altun, İmran İnce, Öznur Gedikli

Acta Neurobiologiae Experimentalis , ISSUE 3, 192–198

research-article

Further evidence of the Diagnostic Utility of the Child Behavior Checklist for identifying pediatric Bipolar I Disorder

score indicates being of lower SES. Not everyone has SES reported. Smaler sample sizes for this measure were: boys ADHD study: 251; girls ADHD study: 219: BP controlled study: 108; all studies combined: 622. bNot everyone has race reported. Smaller sample sizes for this measure were: girls ADHD study: 215, BP disorder controlled study: 139; all studies combined: 649. *Significant difference in percent Caucasian between those with and without bipolar disorder in the BP-I disorder controlled study, p

Amy Yule, Maura Fitzgerald, Timothy Wilens, Janet Wozniak, K. Yvonne Woodworth, Alexa Pulli, Mai Uchida, Stephen V. Faraone, Joseph Biederman

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology , 1–8

Research Article

Further evidence of high level of persistence of pediatric bipolar-I disorder from childhood onto young adulthood: a five-year follow up

Janet Wozniak, Rebecca Wolenski, Maura Fitzgerald, Stephen V. Faraone, Gagan Joshi, Mai Uchida, Joseph Biederman

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology , ISSUE 1, 40–51

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