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  • Immunohematology

 

Article

The gene encoding the I blood group antigen: review of an I for an eye

Unlike most blood group antigen pairs, the I and i antigens are not antithetical (produced by allelic pairs) but, rather, they are reciprocal. The I antigen is formed by the action of an enzyme (a glycosyltransferase), which adds branches onto the i antigen. Thus, branched I antigen is formed at the expense of its precursor, the linear i antigen. The antigens are present on all blood cells and have a wide tissue distribution. Soluble I antigen is found in milk, saliva, and amniotic fluid, and a

Marion E. Reid

Immunohematology , ISSUE 4, 249–252

Review

The Vel blood group system: a review

The blood group antigen Vel has been one of immunohematology’s greatest enigmas: the variation in antigen strength from one individual to another, the property of anti-Vel to readily hemolyze Vel+ red blood cells (RBCs), and the difficulty to screen for sufficient numbers of Vel– blood donors had made Vel a tough nut to crack. In 2013, a small, previously unknown protein called small integral membrane protein 1 (SMIM1) was identified on the RBC by three independent research groups

Jill R. Storry, Thierry Peyrard

Immunohematology , ISSUE 2, 56–59

Review

Immunosuppressive protocols for transplantation and certain hematologic malignancies can prevent the primary immune response to the D blood group antigen

anti-D. The observation that immunosuppressive protocols developed to prevent rejection of tissue and organ transplants also prevented alloimmunization to the D blood group antigen raises the possibility of practical applications in blood transfusion practice.

Adair Seager, S. Gerald Sandler

Immunohematology , ISSUE 3, 110–114

Article

Decreased ABH blood group antigen expression associated with preleukemic conditions and acute leukemia: loss of detectable B, then A antigens in a group AB patient progressing from a myelodysplastic syndrome to leukemia

Decreased or absent expression of blood group antigens is well known to occur in acute leukemia. In some carcinomas, the malignant solid tumor cells have also been shown to lose normal blood group antigen expression. In both carcinoma and hematologic malignancies, these findings have been associated with a more aggressive behavior of the neoplasm. A 34-year-old, group AB, Rh positive woman was diagnosed with a preleukemic condition, myelodysplastic syndrome, in December 1988. In April 1989 B

Kaaron Benson

Immunohematology , ISSUE 4, 89–93

Book Review

BOOK REVIEW: The Blood Group Antigen FactsBook

Gerald Sandler

Immunohematology , ISSUE 2, 63–63

Report

Blood group antigen distribution in Lao blood donors

Chirapha Keokhamphoui, Yupa Urwijitaroon, Douangchanh Kongphaly, Te Thammavong

Immunohematology , ISSUE 4, 132–136

Report

From DNA to blood groups

A blood group antigen is a protein or carbohydrate on the outer surface of a RBC.  Portions of DNA are transcribed and translated into proteins.  A protein-based blood group antigen is the direct product of a gene whereas a carbohydrate-based blood group antigen is an indirect product of a gene; the gene product is a glycosyltransferase that transfers a carbohydrate moiety to a protein, or to another carbohydrate to form a chain of sugars.  This report gives a brief description

Marion E. Reid

Immunohematology , ISSUE 4, 166–169

Report

First example of an FY*01 allele associated with weakened expression of Fya on red blood cells

Patricia A. Arndt, Trina Horn, Jessica A Keller, Rochelle Young, Suzanne M. Heri, Margaret A. Keller

Immunohematology , ISSUE 3, 103–107

Review

The molecular basis of the LU:7 and LU:–7 phenotypes

Kim Hue-Roye, Marion E. Reid

Immunohematology , ISSUE 4, 130–131

Report

SC*994C>T causes the Scnull phenotype in Pacific Islanders and successful transfusion of Sc3+ blood to a patient with anti-Sc3  

Marion E. Reid, Kim Hue-Roye, Randall W. Velliquette, Kathleen Larimore, Sue Moscarelli, Nicolas Ohswaldt, Christine Lomas-Francis

Immunohematology , ISSUE 2, 69–72

Article

Mass-scale donor red cell genotyping using real-time array technology

Blood centers are in the unique position to evaluate large numbers of blood donations for antigen-negative blood types. The limitations with the use of hemagglutination, however, can be circumvented with red cell genotyping. The reagents used for genotyping are synthesized and can be designed for any of the known blood group antigen single nucleotide polymorphisms that are associated with blood group antigen expression. There is interest in the application of mass-scale red cell genotyping of

Gregory A. Denomme, Michael J. Schanen

Immunohematology , ISSUE 2, 69–74

Report

Rh and Kell blood group antigen prevalence in a multi-ethnic cohort in Nigeria: implications for local transfusion service

Ademola Samson Adewoyin, Grace Ming Lee, Titilope Adenike Adeyemo, Omolade Augustina Awodu

Immunohematology , ISSUE 2, 61–65

Article

Confirmation that the JAHK antigen is associated with the rG haplotype

Joanne Kosanke, Jill Storry, Marion Reid

Immunohematology , ISSUE 2, 46–47

Article

Identifying obstetrics patients in whom RHD genotyping can be used to assess risk of D alloimmunization

T.N. Horn, J. Keller, M.A. Keller, L. Klinger

Immunohematology , ISSUE 4, 146–151

Article

Precipitation of serum proteins by polyethylene glycol (PEG) in  pretransfusion testing

Polyethylene glycol (PEG) is used as a potentiator of blood group antigen-antibody interactions. Although PEG is known to precipitate immunoglobulins, we could find no reports of this reagent entrapping red blood cells (RBCs) in irreversible clumps. The patient we describe here had hyperglobulinemia with a reversed albumin: globulin ratio and a diffuse immunoglobulin peak on serum protein electrophoresis. During preparation of serologic tests, a precipitate formed that entrapped the RBCs when

Jack Hoffer, William P. Koslosky, Elizabeth S. Gloster, Therese M. Dimaio, Marion E. Reid

Immunohematology , ISSUE 3, 105–107

Review

JMH blood group system: a review

Susan T. Johnson

Immunohematology , ISSUE 1, 18–23

Article

Alloimmunization by blood group antigens from bone allografts

The purpose of this report is to heighten awareness of the risk of blood group antigen sensitization following bone allografting. Two Rh-negative females of childbearing age developed multiple antibodies to Rh antigens following transplantation of bone from Rh-positive donors. A previous pregnancy and/or blood transfusions were ruled out as factors influencing the antibody production. It is postulated that red cells or red cell stroma in the allografts stimulated the antibody production

C. Elizabeth Musclow, Glen Dietz, Robert S. Bell, Madeleine Beaudry-Clouatre

Immunohematology , ISSUE 4, 102–104

Article

Donath-Landsteiner test

The Donath-Landsteiner (DL) test is a serologic test used to detect the presence of a biphasic hemolysin, seen in patients with paroxysmal cold hemoglobinuria (PCH). The test relies on the characteristic cold binding of an IgG autoantibody with specificity to the P blood group antigen, which causes complement-mediated red blood cell (RBC) lysis when warmed to body temperature. Julius Donath and Karl Landsteiner first described the antibody responsible for this hemolysis in 1904.1 DL antibodies

M. Kilty, T.S. Ipe

Immunohematology , ISSUE 1, 3–6

Article

Blood group antigen profile predicted by molecular biology— use of real-time polymerase chain reaction to genotype important KEL,JK, RHD, and RHCE alleles

Fernando Manuel Ferreira Araújo, Christiana Pereira, Fátima Monteiro, Isabel Henriques, Elsa Meireles, Pedro Lacerda, Ana Aleixo, Regina Celeste, Luis M. Cunha-Ribeiro, Maria J. Rodrigues

Immunohematology , ISSUE 3, 59–64

Review

An update on the GLOB blood group system and collection

The P blood group antigen of the GLOB system is a glycolipid structure, also known as globoside, on the red blood cells (RBCs) of almost all individuals worldwide. The P antigen is intimately related to the Pk and NOR antigens discussed in the review about the P1PK blood group system. Naturally occurring anti-P is present in the serum of individuals with the rare globosidedeficient phenotypes p, P1k, and P2k and has been implicated in hemolytic transfusion reactions as well as unfavorable

Åsa Hellberg, Julia S. Westman, Martin L. Olsson

Immunohematology , ISSUE 1, 19–24

Case report

Evans syndrome in a pediatric liver transplant recipient with an autoantibody with apparent specificity for the KEL4 (Kpb) antigen  

Although most warm red blood cell (RBC) autoantibodies react broadly with panel cells in addition to the patient’s own RBCs, occasionally an autoantibody with specificity for a specific blood group antigen is encountered. Rare cases of warm autoantibodies with specificity for the Kpb antigen of the Kell blood group system have been described. We report a pediatric transplant recipient with anemia, immune-mediated hemolysis, thrombocytopenia, and a warm autoantibody with apparent anti-Kpb

Scott A. Koepsell, Kerry Burright-Hittner, James D. Landmark

Immunohematology , ISSUE 1, 14–17

Article

Reduced red blood cell destruction by antibody fragments

Antibodies to blood group antigens can cause immune RBC destruction directly (extravascular destruction) or indirectly through subsequent complement activation (intravascular hemolysis). The Fc portion of the IgG antibody is responsible for the effector functions of immune RBC destruction. We hypothesized that sensitization of RBCs with blood group antigen–specific IgG antibodies lacking their Fc portion would escape from the recipient’s immune system, allowing for a longer survival

Amina Mqadmi, Steven Abramowitz, Xiaoying Zheng, Karina Yazdanbakhsh

Immunohematology , ISSUE 1, 11–14

Article

DNA from urine sediment or buccal cells can be used for blood group molecular genotyping

Accurate blood group antigen typing of red blood cells with a positive direct antiglobulin test or from a recently transfused patient has been a long-standing problem. To overcome this problem, we evaluated the feasibility of using somatic cells as a source of DNA for molecular genotyping. Two sources of cells that could be obtained by noninvasive procedures were chosen for analysis: urine samples, which were already available in the clinical laboratory, and buccal epithelial cells collected

Marion E. Reid, Maria J. Rios, Kevin L. Cash, Annie M. Strupp, Joan M. Uehlinger

Immunohematology , ISSUE 2, 61–65

Review

The LAN blood group system: a review

LAN (Langereis) was officially recognized by the International Society of Blood Transfusion in 2012 as being the 33rd human blood group system. It consists of one single high-prevalence antigen, Lan (LAN1). The ABCB6 protein is the carrier of the Lan blood group antigen. The ABCB6 gene (chromosome 2q36, 19 exons) encodes the ABCB6 polypeptide (ATP-binding cassette protein, subfamily B, member 6), known as a porphyrin transporter. The exceptional Lan– people do not express ABCB6 (Lan null

Thierry Peyrard

Immunohematology , ISSUE 4, 131–135

Case report

Moderate hemolytic disease of the newborn (HDN) due to anti-Rh17 produced by a black female with an e variant phenotype

The Rh blood group antigen e is of high incidence and has many epitopes. Partial expression may occur, more commonly in black persons. Individuals with e variant phenotypes can make antibodies to epitopes they lack. While some of these antibodies may be specific for an antigen, e.g., hrB, others, like anti-Rh17 (anti-Hro), show broader specificity, compatible only with D– – and Rhnull red blood cells (RBCs). Anti-Rh17 in persons of the D– – phenotype has been reported to

Marla C. Brumit, Gary E. Carnahan, James R. Stubbs, Jill R. Storry, Marion E. Reid

Immunohematology , ISSUE 2, 40–42

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