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  • Acta Neurobiologiae Experimentalis


Research paper | 25-July-2017

BDNF gene polymorphisms and haplotypes in relation to cognitive performance in Polish healthy subjects

The brain derived neurotrophic factor (BDNF) is a neurotrophin that plays an important role in the cell survival, axonal and dendritic growth, and synaptic plasticity. BDNF gene polymorphisms, functional Val66Met mainly, were shown to influence human brain structure and cognition. The aim of the study was to assess the relationship between twelve BDNF gene variants and their haplotypes and cognitive performance measured using the Wisconsin Card Sorting Test (WCST), the Trail

Monika Wiłkość, Agnieszka Szałkowska, Maria Skibińska, Ludmiła Zając-Lamparska, Małgorzata Maciukiewicz, Aleksander Araszkiewicz

Acta Neurobiologiae Experimentalis, Volume 76 , ISSUE 1, 43–52

research-article | 06-April-2020

Neuroprotective effect of poly(lactic-co-glycolic acid) nanoparticle-bound brain-derived neurotrophic factor in a permanent middle cerebral artery occlusion model of ischemia in rats

, immunosuppressants, and excitotoxicity-blocking agents. However, despite efficacy in rodent models, most have failed in clinical trials (Mergenthaler and Meisel, 2012). Therefore, establishing new, effective neuroprotective strategies for AIS is an urgent concern. One of the most promising neuroprotective agents is brain-derived neurotrophic factor (BDNF). BDNF is a neurotrophic protein that belongs to the neurotrophin protein family and is essential for central nervous system (CNS) development, neuronal

Siti Norsyafika Kamarudin, Igor Iezhitsa, Minaketan Tripathy, Renad Alyautdin, Nafeeza Mohd Ismail

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 1, 1–18

research-article | 24-June-2021

Angiotensin IV improves spatial memory in streptozotocin-induced diabetic rats by reducing oxidative stress and altering BDNF levels

on hippocampal oxidative stress and diabetes-induced impairments in cognitive function in streptozotocin (STZ)-induced diabetic rats. The possible mechanisms underlying its effect on cognitive functions were investigated by measuring levels of N-methyl-D-aspartate (NMDA) and gamma-aminobutyric acid A (GABAA) receptors, as well as brain-derived neurotrophic factor (BDNF), as molecular markers of hippocampus-dependent mechanisms of learning and memory. METHODS Ethics and animals Thirty-two male

Aysu Kilic, Savas Ustunova, Birsen Elibol, Huri Bulut, Ismail Meral, Gulderen Sahin

Acta Neurobiologiae Experimentalis, Volume 81 , ISSUE 2, 1–11

Research paper | 06-February-2018

The differential effects of neuroleptic drugs and PACAP on the expression of BDNF mRNA and protein in a human glioblastoma cell line

It has been suggested that, in addition to modulation of monoaminergic neurotransmission, antipsychotic drugs can also affect expression of neurotrophic factors in the brain. The present study was aimed to examine the effects of the first generation neuroleptic drug (FGA; haloperidol) and second generation neuroleptic drugs (SGAs; olanzapine and amisulpride) on expression and level of brain-derived neurotrophic factor (BDNF) in astrocyte-like T98G glioblastoma cell line. Effects of these drugs

Marta Jóźwiak-Bębenista, Magdalena Jasińska-Stroschein, Edward Kowalczyk

Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 3, 205–213

research-article | 30-November-2019

Crocin acts as a neuroprotective mediator against methylphenidate-induced neurobehavioral and neurochemical sequelae: Possible role of the CREB-BDNF signaling pathway

, and neural plasticity, such as the gene that encodes brain-derived neurotrophic factor (BDNF) (Carlezon Jr et al., 2005; Motaghinejad et al., 2017b). BDNF is a significant neurotrophic factor that primarily supports the development and survival of neurons. BDNF is highly expressed in certain brain regions that are implicated in the control of cognition, emotions, and rewards (Hattiangady et al., 2005; Lee et al., 2005). It has been proposed that crocin may protect hippocampal and frontal neurons

Andia Ebrahimzadeh, Sara Yousefi Moghadam, Hanieh Rahimi, Majid Motaghinejad, Manijeh Motevalian, Sepideh Safari, Mobina Abbasi Mesrabadi

Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 4, 352–366

Research paper | 06-February-2018

BDNF expression in cat striate cortex is regulated by binocular pattern deprivation

of brain-derived neurotrophic factor (BDNF), a well-described neurotrophin precipitously regulated by early visual experience. To assess the timing of maturation-related BDNF expression we compared the central and the peripheral visual field representations of area 17 of 1, 2, 4 and 6-month-old and adult cats reared under normal visual conditions. To scrutinize the outcome of BD, four different deprivation strategies were compared, including early onset BD from birth and lasting for 2, 4 or 6

Karolina Laskowska-Macios, Lutgarde Arckens, Małgorzata Kossut, Kalina Burnat

Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 3, 199–204

research-article | 06-April-2020

Investigating the synergic effects of valproic acid and crocin on BDNF and GDNF expression in epidermal neural crest stem cells

INTRODUCTION Brain-derived neurotrophic factor (BDNF) and glial-cell-derived neurotrophic factor (GDNF) are both related to the neurotrophic factor family, which play essential roles in neural development, cell survival, differentiation, and axonal growth, in both the central and peripheral nervous systems, during development and in mature systems (Marsh and Blurton-Jones, 2017). During neurodegenerative disorders, such as spinal cord injury (SCI), Alzheimer’s disease, and Huntington’s disease

Zahra Baharvand, Mohammad Nabiuni, Mohammad Tahmaseb, Elaheh Amini, Sareh Pandamooz

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 1, 38–46

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