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Case report | 10-January-2018

Mild Traumatic Brain Injury: Adapting to Consequences

Mild traumatic brain injury (mTBI) affects more than 28,000 individuals annually in Thailand; however, little information about outcome after mTBI is known. This investigation aimed to explore consequences of mTBI among Thai adults who experienced mTBI in the previous 3-12 months. A sample of 135 adults was interviewed. Subjects were typically men, middle aged and approximately half were married. All completed the compulsory level of education in Thailand and were in the low income bracket

Nutthita Petchprapai

Australasian Journal of Neuroscience, Volume 25 , ISSUE 2, 12–19

Research paper | 31-July-2017

Upregulation of CCL3/MIP‑1alpha regulated by MAPKs and NF‑kappaB mediates microglial inflammatory response in LPS‑induced brain injury

Growing evidence suggests that macrophage inflammatory protein (MIP)‑1alpha (synonym CCL3) is upregulated in the neuroinflammatory processes initiated by some brain disorders, but its precise role and regulatory mechanism remain unclear. The present work aims to evaluate the role of CCL3/MIP‑1alpha in lipopolysaccharide (LPS)‑induced brain injury, and investigate whether the MAPKs and NF‑kappaB regulate CCL3/MIP‑1alpha expression. We firstly examined the patterns of CCL3/ MIP‑1alpha expression

Xiaobo Zhu, Dee Wei, Ou Chen, Zhaohua Zhang, Jiang Xue, Shanying Huang, Weiwei Zhu, Yibiao Wang

Acta Neurobiologiae Experimentalis, Volume 76 , ISSUE 4, 304–317

Research paper | 06-February-2018

Long-term consumption of fermented rooibos herbal tea offers neuroprotection against ischemic brain injury in rats

Stroke is the second leading cause of death worldwide, affecting about 240 people a day in South Africa and leaving survivors with residual disabilities. At the moment, there is no clinically approved neuroprotective product for stroke but the consumption of plant polyphenols has been suggested to offer some protection against stroke. In this study, we investigated the effects of long-term consumption of fermented rooibos herbal tea (FRHT) on ischemia/reperfusion (I/R)-induced brain injury in

Olusiji Akinrinmade, Sylvester Omoruyi, Daneel Dietrich, Okobi Ekpo

Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 1, 94–105

Research paper | 25-July-2017

Surgical injury-induced early neocortical microvascular changes and characteristics of the cells populating the peri-lesion zone

complex 3-dimensional network of basal lamina processes, called fractones. It apparently plays a major role in communication between the various niche-populating cell types as well as in niche activity and output. We hypothesized that similar niches may form ad hoc after a mechanical brain trauma, and tested this possibility in a rat model of surgical brain injury. Four days after removing a small fragment of sensorimotor cortex, the peri-wound region showed numerous symptoms of active repair and

Dorota Sulejczak, Stanisław J. Chrapusta, Wojciech Kozłowski, Małgorzata Frontczak-Baniewicz

Acta Neurobiologiae Experimentalis, Volume 76 , ISSUE 2, 125–141

research-paper | 30-November-2020

Estrogen receptor agonists induce anti-edema effects by altering α and β estrogen receptor gene expression

INTRODUCTION One of the most serious brain injuries, even resulting in death and significant disability, is traumatic brain injury (TBI). Several studies have shown significant gender differences in the pathophysiology and occurrence of TBI. The occurrence of cerebrovascular stroke (CS) in males is also higher than in pre-menopausal females (Kim et al., 2019). In older post-menopausal females, the occurrence of CS is the same as in age-matched males (Howe and McCullough, 2015). Some studies

Mohammad Khaksari, Zahra Hajializadeh, Saeed Esmaeili Mahani, Zahra Soltani, Gholamreza Asadikaram

Acta Neurobiologiae Experimentalis, Volume 81 , ISSUE 3, 286–294

Research paper | 04-May-2018

Effects of different delayed exercise regimens on cognitive performance in fimbria-fornix transected rats

Studies have shown that exercise can positively influence cognitive performance after brain injury. This study investigated the effects of different exercise regimens on allocentric place learning after fimbria-fornix (FF) transection. One hundred and sixteen pre-shaped rats were subjected either to a mechanical transection of the FF or control sham surgery and divided into following groups: i) no exercise (NE), ii) voluntary exercise in a running wheel (RW), iii) forced swimming exercise

Elise Wogensen, Linda Marschner, Marie Gajhede Gram, Siri Mehlsen, Valdemar H. B. Uhre, Pernille Bülow, Jesper Mogensen, Hana Malá

Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 4, 323–336

research-article | 30-November-2019

Newton’s Laws, G-forces and the impact on the brain

literature stand with regard to brain injury and rollercoasters? In 2002 Smith & Meaney suggested that the human body can withstand very large G-forces when they occur over very short periods of time, which is the current thought today. They suggested that the loss of consciousness is from restriction of blood flow rather than mechanical injury to the brain. Their studies illustrated that to injure the brain, there needs to be greater linear force (G’s) as well as rotational force. They went on to say

Vicki Evans

Australasian Journal of Neuroscience, Volume 30 , ISSUE 1, 24–29

Case report | 10-January-2018

Timely Anticoagulant Thromboprophylaxis is Safe and Effective in the Care of Patients Suffering Traumatic Brain Injury.

Kandace Micallef

Australasian Journal of Neuroscience, Volume 25 , ISSUE 2, 30–34

research-article | 06-April-2020

Neuroprotective effect of poly(lactic-co-glycolic acid) nanoparticle-bound brain-derived neurotrophic factor in a permanent middle cerebral artery occlusion model of ischemia in rats

the maximum score (Chen et al., 2001). After assessments, the total score was calculated and the severity of stroke was classified as follows: mild injury (1-6), moderate injury (7-12), severe injury (13-18), or no neurological impairment (0). Thus, the higher the score, the more severe the brain injury. The mNSS assesses motor, sensory, and reflex impairments in animal models after ischemic insults (Schaar et al., 2010). Stroke-induced motor deficits were assessed by the grid-walking test (Chao

Siti Norsyafika Kamarudin, Igor Iezhitsa, Minaketan Tripathy, Renad Alyautdin, Nafeeza Mohd Ismail

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 1, 1–18

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