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  • Acta Neurobiologiae Experimentalis


research-paper | 30-November-2020

Effects of scopolamine treatment and consequent convulsion development in c–fos expression in fed, fasted, and refed mice

INTRODUCTION Immediate early genes encode transcription factors, which is initiated by apoptosis, cell growth, and mitosis (Kaina et al., 1997; Inada et al., 1998; Roche et al., 1999; Scholf et al., 2002). The protein product of the immediate–early gene cfos has been used as a neuronal activation marker (Iwata et al., 1998). Physiological and/or pharmacological stimuli can lead to long–term adaptive responses and activate cfos expression (Bozas et al., 1997; Chiasson et al., 1997; Minson et

Asli Zengin Turkmen, Asiye Nurten, Mine Erguven, Emine Bilge

Acta Neurobiologiae Experimentalis, Volume 81 , ISSUE 3, 264–270

Review | 15-January-2019

c-Fos and neuronal plasticity: the aftermath of Kaczmarek’s theory

require the activity of transcription factors. To test his hypothesis, he focused on c-Fos. His team showed that the c-Fos proto-oncogene is activated by synaptic plasticity and learning, and is required for these phenomena to occur. Subsequent studies showed that timp-1 and mmp-9 are c-Fos effector genes that are required for plasticity. The present review summarizes Kaczmarek’s hypothesis and the major evidence that supports it. We also describe the ways in which knowledge of the molecular

Jacek Jaworski, Katarzyna Kalita, Ewelina Knapska

Acta Neurobiologiae Experimentalis, Volume 78 , ISSUE 4, 287–296

Research paper | 01-August-2017

Spatial memory formation differentially affects c-Fos expression in retrosplenial areas during place avoidance training in rats

The retrosplenial cortex is involved in spatial memory function, but the contribution of its individual areas is not well known. To elucidate the involvement of retrosplenial cortical areas 29c and 30 in spatial memory, we analyzed the expression of c-Fos in these areas in the experimental group of rats that were trained in a spatial place avoidance task, i.e. to avoid shocks presented in an unmarked sector of a stable arena under light conditions. Control rats were trained in the same context

Monika Malinowska, Monika Niewiadomska, Malgorzata Wesierska

Acta Neurobiologiae Experimentalis, Volume 76 , ISSUE 3, 244–256

research-article | 30-November-2018

Differential expression of the c-fos protein and synaptophysin in zebrin II positive and zebrin II negative cerebellar cortical areas in 4-aminopyridine seizures

K+ channels in different neuronal populations, thereby increasing transmitter release and inducing epileptic neuronal activity (Thesleff 1980; Kovács et al., 2003). Given that the major cerebellar afferents operate with glutamic acid transmitters, the postsynaptic effects of 4-AP elicited convulsions can be long-lasting and can be detected with immunohistochemistry (Tóth et al., 2015; 2018). C-fos protein immunohistochemistry can be used as marker of neuronal activity, and for semiquantitative

Beáta Krisztin-Péva, András Mihály, Zoltán Tóth

Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 3, 239–251

Research paper | 10-October-2018

Hindlimb suspension-induced cell apoptosis in the posterior parietal cortex and lateral geniculate nucleus: corresponding changes in c-Fos protein and the PI3K/Akt signaling pathway

microgravity environment for 0 (Control group), 7, 14, or 28 days. We found a significant increase in cellular apoptosis in the PPC and the LGN after 7 days of simulated microgravity. In addition, there was an increase in expression of c-Fos protein in the PPC, and a repression of the PI3K/Akt signaling pathway in the LGN after 7 days. Based on these results, we conclude that short-term simulated microgravity may induce cell apoptosis in the PPC and LGN, and reflect a neural adaptive process to accommodate

Wei Huang, Chen Chen, Xufeng Liu

Acta Neurobiologiae Experimentalis, Volume 78 , ISSUE 3, 220–230

Short Communication | 06-February-2018

In vivo stimulation of locus coeruleus: effects on amygdala subnuclei

functional connectivity between the LC and the amygdala subnuclei. To reach this objective, we evaluated c-fos immunoreactive cells in amygdala nuclei following direct electrical stimulation of the LC in conscious animals. This analysis of c-fos immunoreactivity could inform whether there are differences in activity of the amygdala subnuclei related to LC electrical stimulation in conscious animals. Our results showed a marked increase in c-fos activity in these amygdala subnuclei both ipsilateral and

Elisa Rodríguez-Ortega, Fernando Cañadas, Francisca Carvajal, Diana Cardona

Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 3, 261–268

Research paper | 22-August-2018

Fos immunoreactivity in the intermediolateral nucleus induced by tendon vibration of the m. triceps surae in rats pretreated with a nitric oxide blocker or precursor

We investigated neuronal activation of the rat intermediolateral (IML) nucleus of the thoracolumbar spinal cord, initiated by Achilles tendon vibration, after intramuscular (m. triceps surae) administration of 7-nitroindazole (7-NI) or L-arginine (LA). The spindle afferent response to vibratory stimuli induced a distinct bilateral increase in the activation of c-Fos immunoreactivity in the spinal neurons in three groups of rats (tendon-vibrated, tendon-vibrated + 7-NI and tendon-vibrated + LA

Inna V. Vereshchaka, Andriy V. Maznychenko, Olena P. Mankivska, Volodymyr O. Maisky, Oleh V. Vlasenko, Olexandr V. Dovgan, Olga L. Ocheretna, Tomasz Tomiak, Alexander I. Kostyukov

Acta Neurobiologiae Experimentalis, Volume 78 , ISSUE 2, 82–91

research-article | 30-November-2018

Stimulus-seeking in rats is accompanied by increased c-Fos expression in hippocampal CA1 as well as short 22 kHz and flat 50 kHz calls

. We also examined CA1, CA3, and the dentate gyrus (DG) of the hippocampal formation, as their involvement in controlling and guiding emotions, motivation, and cognition is well documented (Hess et al., 1995; Mohammed et al., 2002; Turner et al., 2002; Knapska et al., 2007). As a method of choice, we used the c-Fos protein, which is a product of immediate-early genes and expression levels are often utilised as a marker of neuronal activity and plasticity, e.g. in our previous works (Kaminska et al

Ita Robakiewicz, Monika Polak, Małgorzata Rawska, Dominik Alberski, Rafał Polowy, Kinga Wytrychiewicz, Mateusz Syperek, Jan Matysiak, Robert K. Filipkowski

Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 3, 310–318

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