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  • Polish Journal Of Microbiology

 

Original Paper

Emodin Reduces the Activity of (1,3)-β-D-glucan Synthase from Candida albicans and Does Not Interact with Caspofungin

molecules, interaction of emodin with caspofungin was determined. The study revealed that emodin reduced (1,3)-β-D-glucan synthase activity and increased cell wall damage, which was evidenced by both a sorbitol protection assay and an aniline blue staining assay. Furthermore, the synergy testing method showed mainly independence of the action of both tested antifungal agents, i.e. emodin and caspofungin used in combination.

MONIKA JANECZKO

Polish Journal of Microbiology , ISSUE 4, 463–470

original-paper

Prevalence and Antifungal Susceptibility of the Emerging Fungal Species, Candida nivariensis, Isolated in a Teaching Hospital in Poland

), voriconazole (VOR), caspofungin (CAS), anidulafungin (ANF), and micafungin (MCF) were measured. MIC results (S – susceptible and R – resistant) of FLU, AMB, CAS, MCF, and ANF were interpreted following the European Committee on Antimicrobial Susceptibility Testing (EUCAST) guidelines (EUCAST 2018). In details, the interpretation for antifungals MICs was as follows: AMB ≤ 1 susceptible, > 1 resistant, FLU ≤ 0,002 susceptible, MCF ≤ 0,032 susceptible, > 0,032 resistant, ANF ≤ 0,064 susceptible, > 0,064

MAGDALENA SIKORA, ROBERT KUTHAN, KATARZYNA PISKORSKA-MALOLEPSZA, MARLENA GOLAS-PRADZYNSKA, DARIUSZ DOMAŃSKI, EWA AUGUSTYNOWICZ-KOPEĆ, EWA SWOBODA-KOPEC

Polish Journal of Microbiology , ISSUE 3, 303–308

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