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Rational polytherapy: Myth or reality?

action (MoA). These properties of the SGAEDs lead to a re-evaluation of the polytherapy strategy and to new methods of choosing a second (or more) AED. This new approach was called rational polytherapy (RP) (Ferrendelli, 1995; Anonimous, 1995). In essence, RP consists of selecting combinations of AEDs that result in a greater clinical efficacy (additive or synergistic effect) compared to the one obtained by chance, but with additive or even infraadditive, toxicity. In other words, RP was defined as

José Pimentel, José Manuel Lopes Lima

Journal of Epileptology, Volume 27 , 27–34

Review Paper

Selected classical and novel antiepileptic drugs – mechanisms of action, neuroprotection, and effectiveness in epileptic and non-epileptic conditions

Introduction. One of the most common neurological disorders is epilepsy, characterised by recurrent spontaneus seizures. Although not fully efficient in ca 30% of patients, pharmacologic treatment of epilepsy plays an important therapeutic approach not only against epilepsy. Aim. To provide data on the mechanism of action, activity and neuroprotective efficacy in experimental conditions, clinical efficacy against epilepsy and non-epileptic diseases of major, classical and newer antiepileptic

Magdalena Chrościńska-Krawczyk, Magdalena Wałek, Bożydar Tylus, Stanisław J. Czuczwar

Journal of Epileptology, Volume 22 , ISSUE 1, 37–50

Research Article


Empiric therapy has been applied in the treatment of Lyme disease. This therapy is selected following the sensitivity analysis of the proposed drug in all species of bacteria which can cause a similar type of infection and on the basis of the clinical efficacy of antibiotic treatment. Established schemes based on data collected from many centers in the world, including type of antibiotic, dose and duration of his administration, and the stage and form of Lyme disease have been created. Number

Tomasz Chmielewski, Stanisława Tylewska-Wierzbanowska

Postępy Mikrobiologii - Advancements of Microbiology, Volume 56 , ISSUE 3, 335–339

Research paper

The use of MR-less MNI based neuronavigation for 10 Hz rTMS depression therapy: electrophysiological and clinical implications

2 patients. There was a significantly larger decrease of the Hamilton Depression Rating Scale (HAM-D) scores in the Group 3 (66.94%) compared to Group 1 (57.52%) and Group 2 (56.02%). This suggests it is possible to achieve higher clinical efficacy and less physiological impact on the brain when using different targets in a neuronavigated MNI based MR-less rTMS system.

Vladas Valiulis, Giedrius Gerulskis, Kastytis Dapšys, Karolina Valavičiūtė, Aldona Šiurkutė, Valentinas Mačiulis

Acta Neurobiologiae Experimentalis, Volume 78 , ISSUE 3, 271–280

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