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  • Acta Neurobiologiae Experimentalis

 

Research paper | 25-July-2017

Chronotype and sleep quality as a subphenotype in association studies of clock genes in mood disorders

suggests a putative role of the analyzed clock genes polymorphisms in chronotype in the control group and in sleep quality disturbances in the course of MD. The results indicate that PSQI variables can be used to refine phenotype in association studies of clock genes in MD.

Monika Dmitrzak-Węglarz, Joanna Pawlak, Monika Wiłkość, Izabela Miechowicz, Małgorzata Maciukiewicz, Wanda Ciarkowska, Dorota Zaremba, Joanna Hauser

Acta Neurobiologiae Experimentalis, Volume 76 , ISSUE 1, 32–42

review-article | 05-September-2020

Timing - Understanding Central and Peripheral Clocks

hypothalamus of the brain. The cells of the SCN contain a number of ‘clockgenes that are able to keep time by transcriptional/translational feedback loops that operate on an approximate 24 hour cycle (12). The primary genes involved in this process are Clock (circadian locomotor output cycles kaput), Bmal1 (brain and muscle arnt-like protein-1, also known as Arntl), Cry (cryptochrome) 1 and 2, and Per (period) 1, 2, and 3 for the primary positive loop. Secondary loop genes include Rev-ERBα (reverse

JM Stepien, A Coates, S. Banks

Eat, Sleep, Work, Volume 3 , 18–38

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