Research paper | 25-July-2017
suggests a putative role of the analyzed clock genes polymorphisms in chronotype in the control group and in sleep quality disturbances in the course of MD. The results indicate that PSQI variables can be used to refine phenotype in association studies of clock genes in MD.
Acta Neurobiologiae Experimentalis, Volume 76 , ISSUE 1, 32–42
review-article | 05-September-2020
hypothalamus of the brain. The cells of the SCN contain a number of ‘clock’ genes that are able to keep time by transcriptional/translational feedback loops that operate on an approximate 24 hour cycle (12). The primary genes involved in this process are Clock (circadian locomotor output cycles kaput), Bmal1 (brain and muscle arnt-like protein-1, also known as Arntl), Cry (cryptochrome) 1 and 2, and Per (period) 1, 2, and 3 for the primary positive loop. Secondary loop genes include Rev-ERBα (reverse
Eat, Sleep, Work, Volume 3 , 18–38