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Review Paper | 10-December-2015

Antiepileptic drugs as a new therapeutic concept for the prevention of cognitive impairment and Alzheimer’s disease. Recent advances

Introduction. Excessive accumulation of amyloid-beta (A_) peptides in the brain results initially in mild cognitive impairment (MCI) and finally in Alzheimer’s disease (AD). Evidences from experimental and clinical studies show that pathological hyperexcitability of hippocampal neurons is a very early functional impairment observed in progressive memory dysfunctions. Therefore, antiepileptic drugs (AEDs) whose mechanism of action is aimed at inhibition of such neuronal hyperexcitability

Krzysztof Sendrowski, Wojciech Sobaniec

Journal of Epileptology, Volume 23 , ISSUE 2, 139–147

Practice Report | 29-August-2014

Cognitive impairment predicts social disability in persons with epilepsy

Introduction. Cognitive dysfunction is one of the main comorbidities of epilepsy which co-exists with seizures and contributes to the adverse impact of the disease on employment, education and interpersonal relationships. A fundamental question regarding cognitive dysfunction in epilepsy goes as follows: in comparison to seizures, what role does cognitive dysfunction play in causing social disability? The purpose of this review was to evaluate our understanding of the role cognitive impairment

Krzysztof A. Bujarski, Gabriella Wozniak, Erik J. Kobylarz

Journal of Epileptology, Volume 22 , ISSUE 2, 89–97

Case report | 05-May-2015

Cognitive functions in myoclonic epilepsy with ragged red fibres – a case report

Introduction. Myoclonic epilepsy with ragged red fibers (MERRF) is a rare, progressive mitochondrial disease affecting multiple systems, including the central nervous system. Typical MERRF symptoms include: myoclonus, epileptic seizures, ataxia and cognitive decline. In mitochondrial diseases selective cognitive impairment or generalized decline, called mitochondrial dementia, is usually diagnosed. Description of case. We present the case of an 18-year-old patient with progressive neurological

Martyna Domańska, Emilia J. Sitek, Michał Schinwelski, Maria Mazurkiewicz-Bełdzińska, Agnieszka Matheisel, Jarosław Sławek

Journal of Epileptology, Volume 23 , ISSUE 1, 69–74

Review Paper | 09-December-2014

Encephalopathy with Electrical Status Epilepticus in Slow Wave Sleep – a review with an emphasis on regional (perisylvian) aspects

regional age dependent hyperexcitability syndromes (prototype of the centro-temporal spikes of Rolandic epilepsy). The main mechanism of the developing cognitive impairment is most probably the consequence of interference with plastic function of slow wave sleep by obliterating synaptic decline during sleep. Presently, the consensus and co-operative research is highly obstacled by the terminological chaos, the controversial definitions and views around this still striking and enigmatic phenomenon.

Peter Halász, Márta Hegyi, Zsuzsa Siegler, András Fogarasi

Journal of Epileptology, Volume 22 , ISSUE 2, 71–87

Original Paper | 31-March-2014

Handedness, cognitive processing and intelligence in patients with epilepsy

) with epilepsy participated in the study. Patients were divided into two groups. The first group included 112 patients that were characterized by intelligence and cognitive impairment while the second group (20 patients) had no mental deterioration and was regarded as controls. The two diagnostic categories accorded with ICD-10 criteria. The diagnosis of Dementia (F-02.8) was confirmed in 54 patients, while the diagnosis of Mild Cognitive Impairment (F-06.7) was confirmed in 58 patients. Results

Vladimir V. Kalinin, Daniya M. Nazmetdinova, Alexander V. Basamygin

Journal of Epileptology, Volume 22 , ISSUE 1, 5–10

Research paper | 31-July-2017

The effect of network template from normal subjects in the detection of network impairment

Chun‑Chao Huang, Shang‑Hua Lin, Ching‑Po Lin, The Alzheimer’s Disease Neuroimaging Initiative

Acta Neurobiologiae Experimentalis, Volume 76 , ISSUE 4, 294–303

research-paper | 14-June-2019

Neuroprotective effects of lipopolysaccharide and naltrexone co-preconditioning in the photothrombotic model of unilateral selective hippocampal ischemia in rat

Sayed Masoud Hosseini, Alireza Golaghaei, Ehsan Nassireslami, Nima Naderi, Hamid Gholami Pourbadie, Milad Rahimzadegan, Saeid Mohammadi

Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 1, 73–85

research-article | 30-November-2020

Aminoguanidine ameliorates ovariectomy-induced neuronal deficits in rats by inhibiting AGE-mediated Aβ production

inhibits Aβ-induced nuclear factor (NF)-κB p65 from translocating into the cytosol and prevents Aβ-induced neurological disorders through reducing the expression of iNOS and Cyclooxygenase-2 (COX-2) and inactivating NF-κB (Chen et al., 2017). To summarize, due to the anti-inflammatory and neuromodulatory advantages of AG, we considered it worthwhile to investigate the effects of AG on oestrogen deficiency-induced learning and cognitive impairment and Aβ production mediated by AGEs, which have not yet

Dan Di Zhang, Yan Gang Wang, Chun Yan Liu, Ze Hou Wang, Yue Fen Wang

Acta Neurobiologiae Experimentalis, Volume 81 , 1–11

Original Paper | 02-June-2015

The effect of seizures on functional status of people with spastic forms of cerebral palsy

Background. Cerebral palsy (CP) is the most common childhood motor impairment. Epilepsy affects approximately one third of patients with CP. It is characterized by earlier disclosure, it is more severe and shows greater resistance than that of the general epilepsy treatment, associated with necessity for polytherapy. Its presence can result in gradual loss of function, loss of posture in non-ambulant individuals with severe disabilities and cognitive impairment risk, behavioural disorders and

Agata Michalska, Janusz Wendorff

Journal of Epileptology, Volume 23 , ISSUE 2, 91–102

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