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  • Acta Neurobiologiae Experimentalis


research-article | 15-October-2020

Antistress and antidepressant properties of dapoxetine and vortioxetine

play a significant role in the disease’s pathomechanism. HPA axis adverse effect on the mood by the induced release of corticoliberin (hypothalamus) and cascade release of corticotropin (pituitary gland), and then of cortisol (adrenal glands – the animal equivalent of the human stress hormone is corticosterone). Excessive exposure to stress increases the cortisol blood level and disturbs the HPA axis (in normal physiological conditions, high cortisol level would inhibit corticotropin-releasing

Piotr Ratajczak, Krzysztof Kus, Małgorzata Zielińska-Przyjemska, Beata Skórczewska, Tomasz Zaprutko, Dorota Kopciuch, Anna Paczkowska, Elżbieta Nowakowska

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 3, 217–224

Research paper | 31-July-2017

Anhedonia but not passive floating is an indicator of depressive‑like behavior in two chronic stress paradigms

corticosterone in the blood and brain structures involved in stress‑response did not differ from control in both experiments. The absence of significant changes in corticosterone levels and passive floating may be indicative of the adaptation of animals to chronic stress. Anhedonia appears to be a more sensitive indicator of depressive‑like behavioral effects of chronic stress as compared to behavior in the forced swim or open field tests.

Mikhail Yu. Stepanichev, Anna O. Tishkina, Margarita R. Novikova, Irina P. Levshina, Sofiya V. Freiman, Mikhail V. Onufriev, Olga A. Levchenko, Natalia A. Lazareva, Natalia V. Gulyaeva

Acta Neurobiologiae Experimentalis, Volume 76 , ISSUE 4, 324–333

research-article | 30-November-2019

Decreased serotonin content and release in the ventral hippocampus of prenatally stressed male rats in response to forced swim test

) of ventral hippocampus, and its possible correlation with sucrose preference and the FST in adulthood. Serum corticosterone concentration was also evaluated in order to assess adrenal response to the FST. METHODS Subjects Three-month-old female Wistar rats weighing 250 grams were provided by the vivarium of the Autonomous Metropolitan University, Iztapalapa. Rats were kept under standard laboratory conditions, under an inverted light/dark cycle (lights off at 09: 00), temperature 23°C ±1, food

Felipe de Jesús Jiménez Vásquez, Diana Méndez Guerrero, Moisés Rubio Osornio, María del Carmen Rubio Osornio, Sandra Orozco Suárez, Socorro Retana-Márquez

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 4, 331–343

research-article | 30-November-2019

Serotonin and noradrenaline content and release in the dorsal hippocampus during learning and spatial memory in prenatally stressed rats

pore, and 10 μL of the filtered sample were injected to a high-performance liquid chromatography system with electrochemical detection (HPLC-ED). Trunk blood was also collected for serum corticosterone quantification. Microdialysis procedure In other control and prenatally stressed males (n=50, each), stereotaxic surgeries were performed. Rats were anesthetized with ketamine (PiSA® S.A. DE C.V. Mexico, 8 mg/kg, i.p.) and xylazine (PiSA® S.A. DE C. V. Mexico, 20 mg/kg, i.m.). A guide cannula was

Diana Méndez Guerrero, Felipe de Jesús Jiménez Vásquez, Moisés Rubio Osornio, María del Carmen Rubio Osornio, Sandra Orozco Suárez, Socorro Retana-Márquez

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 4, 400–410

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