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Mini Review | 30-June-2018

Non-antibiotics, Efflux Pumps and Drug Resistance of Gram-negative Rods

absence of activity against Gram-negative rods is related, among other things, to the extrusion of these compounds from bacterial cells by multi-drug resistance efflux pumps. Substrates for the resistance-nodulation-division efflux systems include the following non-antibiotics: salicylate, diclofenac, ibuprofen, mefenamic acid, naproxen, amitriptyline, alendronate sodium, nicergoline, and ticlopidine. In addition, interactions between non-antibiotics and multi-drug resistance efflux pumps have been

AGNIESZKA EWA LAUDY

Polish Journal of Microbiology, Volume 67 , ISSUE 2, 129–135

Research Article | 23-May-2019

DRUG RESISTANCE IN THE GENUS ENTEROCOCCUS – CURRENT PROBLEM IN HUMANS AND ANIMALS

Drug-resistant bacteria from the genus Enterococcus are currently among the most important pathogens behind healthcare-associated infections. The drug resistance of these bacteria has been on the increase since the 1980s, leeding to their multi-drug resistance. Selective pressure, present mainly in the hospital environment, contributed to this phenomenon. However, also outside the hospital environment selective pressure comes into play, namely the use of antibiotics as promoters of growth in

Katarzyna Talaga-Ćwiertnia, Małgorzata Bulanda

Postępy Mikrobiologii - Advancements of Microbiology, Volume 57 , ISSUE 3, 244–250

Short Communication | 07-June-2016

Monitoring of Virulence Genes, Drug-Resistance in Campylobacter coli Isolated from Golden Retrievers

Marek Selwet, Mariola Galbas, Ryszard Słomski, Tomasz Cłapa, Filip Porzucek

Polish Journal of Microbiology, Volume 65 , ISSUE 2, 237–240

original-paper | 05-December-2019

Epidemiology, Drug Resistance, and Virulence of Staphylococcus aureus Isolated from Ocular Infections in Polish Patients

III) than strains from non-hospitalized patients. Table III Drug resistance of Staphylococcus aureus strains isolated from ocular infections. Antimicrobial category Antimicrobial agent Hospitalization n (%) Total, N = 83 Yes, n = 61 (73.4%) No, n = 22 (26.5%) Aminoglycosides Gentamicin 4 (6.5%) 1 (4.5%) 5 (6.0%) Amikacin 5 (8.1%) 3 (13.6%) 8 (9.6%) Tobramycin 9 (14.7%) 5 (22.7%) 14 (16.8%) Neomycin 37 (60.6%) 11 (50.0%) 48 (57.8%) Fluoroquinolones Ciprofloxacin 4 (6.5

MARTA KŁOS, MONIKA POMORSKA-WESOŁOWSKA, DOROTA ROMANISZYN, AGNIESZKA CHMIELARCZYK, JADWIGA WÓJKOWSKA-MACH

Polish Journal of Microbiology, Volume 68 , ISSUE 4, 541–548

Case report | 11-March-2014

Successful treatment with adjunctive lacosamide in a patient with long term “drug resistant” focal epilepsy

Walter Fröscher, Alois Rauber

Journal of Epileptology, Volume 22 , ISSUE 1, 51–55

Original Paper | 02-April-2015

The ILAE definition of drug resistant epilepsy and its clinical applicability compared with “older” established definitions

course of disease were extracted from patients' charts. Drug resistant epilepsy was classified according to four definitions and the time until fulfillment of criteria compared. Results. Mean time to fulfillment of criteria of drug resistant epilepsy ranged from 11.8 (standard deviation (SD) 9.8) to 15.6 years (SD 11.3). Time to drug resistance was significantly longer applying the only definition, requiring failure of three antiepileptic drugs (AEDs) (Canada definition), whereas time to

Alexandra Rohracher, Judith Dobesberger, Claudia A. Granbichler, Julia Höfler, Giorgi Kuchukhidze, Martin Ortler, Iris Unterberger, Gerald Walser, Aljoscha Thomschewski, Eugen Trinka

Journal of Epileptology, Volume 23 , ISSUE 1, 39–44

Original Paper | 10-December-2018

Emergence of High-level Gentamicin Resistance among Enterococci Clinical Isolates from Burn Patients in South-west of Iran: Vancomycin Still Working

MARYAM LABIBZADEH, GHOLAM ABBAS KAYDANI, MOHAMMAD SAVARI, ALIREZA EKRAMI

Polish Journal of Microbiology, Volume 67 , ISSUE 4, 401–406

original-paper | 06-April-2020

Prevalence of Multi-Drug Resistant Mycobacterium Tuberculosis in Khyber Pakhtunkhwa – A High Tuberculosis Endemic Area of Pakistan

vulnerable populations across the world and remains a leading global public health problem. Treatment of drug-susceptible TB takes six months while treatment of rifampicin-resistant TB (RR-TB) and multidrug-resistant TB (MDR-TB) requires a long therapy for up to two years (WHO 2019). Globally, an 85% successful treatment rate has been reported for drug-susceptible MTB. The emergence of drug resistance, however, still poses a threat to global efforts. The WHO estimated 10.4 million new TB cases consist of

SAJID ALI, MUHAMMAD TAHIR KHAN, ANWAR SHEED KHAN, NOOR MOHAMMAD, MUHAMMAD MUMTAZ KHAN, SAJJAD AHMAD, SADIQ NOOR, ABDUL JABBAR, CANTILLON DAIRE, FARIHA HASSAN

Polish Journal of Microbiology, Volume 69 , ISSUE 2, 133–137

original-paper | 03-September-2019

Evaluation of the pol/S Gene Overlapping Mutations in Chronic Hepatitis B Patients in Northern Cyprus

. For HBV infection, the prevalence rate ranges from 1.2% (160/13 892) (Arikan et al. 2016) to 1.35% (339/25 442) (Guler et al. 2018). For Southern Cyprus, this rate was given as 0.77% and 1.01% (Altindis et al. 2016). Although there are few studies regarding the prevalence, up to now, there has been no publication on drug resistance in patients infected with HBV in Northern Cyprus (Altindis et al. 2006; Suer et al. 2014). Therefore, we aimed to show the presence of resistance mutations and their

AYSE ARIKAN, MURAT SAYAN, TAMER SANLIDAG, KAYA SUER, SINEM AKCALI, MERYEM GUVENIR

Polish Journal of Microbiology, Volume 68 , ISSUE 3, 317–322

Article | 24-March-2021

SANDBOXES AS A POTENTIAL SOURCE OF DANGEROUS DRUG-RESISTANT ESCHERICHIA COLI AND STAPHYLOCOCCUS AUREUS STRAINS

Edyta Mazur, Maria Jolanta Chmiel

Postępy Mikrobiologii - Advancements of Microbiology, Volume 60 , ISSUE 1, 77–89

Original Paper | 10-December-2018

Drug Susceptibility of Non-tuberculous Strains of Mycobacterium Isolated from Birds from Poland

antituberculous drugs most commonly used in the treatment of mycobacterial infections in humans. For drug susceptibility tests, drugs such as isoniazid, rifampicin, streptomycin, ethambutol, ofloxacin, capreomycin, cycloserine and ethionamide were used. A high degree of drug resistance was demonstrated, particularly in Mycobacterium avium. Isolates of Mycobacterium xenopi showed a relatively good susceptibility to the drugs tested. The drug resistance of Mycobacterium genavense has not been determined, but

ALEKSANDRA LEDWOŃ, AGNIESZKA NAPIÓRKOWSKA, EWA AUGUSTYNOWICZ- KOPEĆ, PIOTR SZELESZCZUK

Polish Journal of Microbiology, Volume 67 , ISSUE 4, 487–492

original-paper | 29-May-2020

A Current Microbiological Picture of Mycobacterium Isolates from Istanbul, Turkey

-tuberculosis drug resistance remains a significant problem. Of the primary anti-tuberculosis drugs, isolates showing at least isoniazid (INH) and rifampin (RIF) resistance are defined as Multiple Drug-Resistant Tuberculosis (MDR-TB) (WHO 2019). In this study, we aimed to document Mycobacterium species isolated in a large metropolitan tertiary care hospital in Turkey. The laboratory procedures used to isolate the organisms were also compared. Similarly, the resistance rates to the 1st-line anti-tuberculosis

BILGE SUMBUL, MEHMET ZIYA DOYMAZ

Polish Journal of Microbiology, Volume 69 , ISSUE 2, 185–191

original-paper | 22-October-2019

Molecular Epidemiology of Hepatitis B Virus in Turkish Cypriot

) are observed, and HBV is characterized by a significant degree of genetic heterogeneity (Kostaki et al. 2018). The HBV genome encloses four partially overlapping open reading frames, which are PreS1/S2/S, PreC/C, P, and X encoding seven different proteins. Most significantly, Reverse Transcriptase (RT) and HBsAg frames overlap at RT amino acid 8–236, with HBsAg frameshift downstream by one nucleotide. Therefore, it indicates that mutations in these specific areas might result in drug resistance

UNAL SUMER, MURAT SAYAN

Polish Journal of Microbiology, Volume 68 , ISSUE 4, 449–456

Original Paper | 10-December-2018

Microbiology and Drug Resistance of Pathogens in Patients Hospitalized at the Nephrology Department in the South of Poland

MIKOŁAJ MICHNO, ANTONI SYDOR, MARTA WAŁASZEK, WŁADYSŁAW SUŁOWICZ

Polish Journal of Microbiology, Volume 67 , ISSUE 4, 517–524

Short Communication | 30-March-2017

Outpatient Antibiotic Consumption Fluctuations in a View of Unreasonable Antibacterial Therapy

Marcin Ciszewski, Tomasz Czekaj, Eligia M. Szewczyk

Polish Journal of Microbiology, Volume 66 , ISSUE 1, 119–123

research-paper | 12-August-2019

Coumarins as potential supportive medication for the treatment of epilepsy

Jarosław Bryda, Mirosław Zagaja, Aleksandra Szewczyk, Marta Andres-Mach

Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 2, 126–132

mini-review | 27-December-2020

Hepatitis B Virus: From Diagnosis to Treatment

different genome regions. These regions may encode for polymerase, surface antigen, core/precore promoter, and comprise the X genes that significantly influence HBsAg expression and progression of HCC (Shaha et al. 2018; Arikan et al. 2019). Additionally, due to the complete overlapping of pol and S genes, drug resistance and nucleos(t)ide resistance mutations occurring in the pol gene can lead to changes in its product HBsAg (Kırdar et al. 2019). The mutations in the gene C that encode for precore and

MERYEM GUVENIR, AYSE ARIKAN

Polish Journal of Microbiology, Volume 69 , ISSUE 4, 391–399

minireview | 24-February-2021

The Pathogenesis of Aspergillus fumigatus, Host Defense Mechanisms, and the Development of AFMP4 Antigen as a Vaccine

drugs, they failed to provide satisfying treatment for invasive aspergillosis patients. Notably, the clear side effects of antifungal drugs such as amphotericin B’s kidney toxicity and the potential hepatotoxicity of itraconazole discouraged their clinical use. Although voriconazole had better penetration than amphotericin B and itraconazole, it might cause temporary hepatotoxicity. In addition to the side effects of antifungal drugs, drug resistance and high cost also greatly hindered the use of

XIANG GU, YAN-HONG HUA, YANG-DONG ZHANG, DI BAO, JIN LV, HONG-FANG HU

Polish Journal of Microbiology, Volume 70 , ISSUE 1, 3–11

original-paper | 05-December-2019

Inhibition of Drug Resistance of Staphylococcus aureus by Efflux Pump Inhibitor and Autolysis Inducer to Strengthen the Antibacterial Activity of β-lactam Drugs

Introduction Staphylococcus aureus infection and drug resistance problems have caused increasing public health problems. The increase in antimicrobial resistance coupled with intracellular infection makes this bacteria the third-largest threat to human health according to the WHO (Lowy 1998; Demon et al. 2012). MRSA is of particular concern because of its ability to spread extensively and rapidly, along with its multi-drug resistance to β-lactam and aminoglycoside antibiotics (Boucher et al

WENJING LUAN, XIAOLEI LIU, XUEFEI WANG, YANAN AN, YANG WANG, CHAO WANG, KESHU SHEN, HONGYUE XU, SHULIN LI, MINGYUAN LIU, LU YU

Polish Journal of Microbiology, Volume 68 , ISSUE 4, 477–491

original-paper | 08-September-2020

Characterization of Two Macrolide Resistance-Related Genes in Multidrug-Resistant Pseudomonas aeruginosa Isolates

. 2017; Ero et al. 2019). In this study, we analyzed the resistance spectrum, and the MIC levels of clinical P. aeruginosa isolates to commonly used in the clinic antibiotics and further analyzed the molecular mechanisms of the bacteria’s resistance to macrolides. Understanding the molecular mechanisms of drug resistance will help clinicians treat infectious diseases and prevent the spread of resistance more effectively. Experimental Materials and Methods Bacterial strains collection, genomic DNA

QING CHEN, WEI LU, DANYING ZHOU, GUOTONG ZHENG, HONGMAO LIU, CHANGRUI QIAN, WANGXIAO ZHOU, JUNWAN LU, LIYAN NI, QIYU BAO, AIFANG LI, TENG XU, HAILI XU

Polish Journal of Microbiology, Volume 69 , ISSUE 3, 349–356

original-paper | 28-June-2019

Patterns of Drug-Resistant Bacteria in a General Hospital, China, 2011–2016

provides useful information for prevention and helps clinicians prescribe the effective antibiotic therapy (Ventola 2015), as well as optimize the use of antibiotics, which has become one of the most important parts of drug resistance control (Lafaurie et al. 2012; Wang et al. 2018). In this study, the significant changes and trends in antibiotic resistance of clinically important pathogens isolated from a general hospital in Zhengzhou, Henan Province, China, from 2011 to 2016 were described to provide

TINGTING MAO, HUIJUAN ZHAI, GUANGCAI DUAN, HAIYAN YANG

Polish Journal of Microbiology, Volume 68 , ISSUE 2, 225–232

original-paper | 03-September-2019

Prevalence and Antifungal Susceptibility of the Emerging Fungal Species, Candida nivariensis, Isolated in a Teaching Hospital in Poland

pathogenicity determinants of C. glabrata sensu lato is their ability to adhere to abiotic and biotic surfaces, to form biofilm on both surfaces, and to secrete phospho- and lipases, hemolysins, and other cytotoxic enzymes. (Tamura et al. 2007; Silva et al. 2012; Rodrugues et al. 2014). Little is known about the drug resistance of the C. glabrata species complex. Some studies suggest that the new species within the complex may be more resistant to antifungals than C. glabrata sensu stricto (Tamura et al

MAGDALENA SIKORA, ROBERT KUTHAN, KATARZYNA PISKORSKA-MALOLEPSZA, MARLENA GOLAS-PRADZYNSKA, DARIUSZ DOMAŃSKI, EWA AUGUSTYNOWICZ-KOPEĆ, EWA SWOBODA-KOPEC

Polish Journal of Microbiology, Volume 68 , ISSUE 3, 303–308

Review Paper | 25-January-2016

Natural course of treated epilepsy and medico-social outcomes. Turku studies. Part II

remitting, uninterrupted by relapse (in 48%); a remitting-relapsing course (interrupted by relapses, in terminal remission) (19%); worsening course (early or late remission followed by drug-resistant epilepsy) (14%); and never in ≥5-year remission (drug resistance) (19%) The medical and social outcomes based on my unique, five decades followed cohort show that most subjects are in 10-year remission without medications, which is the definition of resolved epilepsy. Normal or subnormal IQ, non

Matti Sillanpää

Journal of Epileptology, Volume 24 , ISSUE 1, 25–39

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