Mini Review | 30-June-2018
absence of activity against Gram-negative rods is related, among other things, to the extrusion of these compounds from bacterial cells by multi-drug resistance efflux pumps. Substrates for the resistance-nodulation-division efflux systems include the following non-antibiotics: salicylate, diclofenac, ibuprofen, mefenamic acid, naproxen, amitriptyline, alendronate sodium, nicergoline, and ticlopidine. In addition, interactions between non-antibiotics and multi-drug resistance efflux pumps have been
AGNIESZKA EWA LAUDY
Polish Journal of Microbiology, Volume 67 , ISSUE 2, 129–135
Research Article | 23-May-2019
Drug-resistant bacteria from the genus Enterococcus are currently among the most important pathogens behind healthcare-associated infections. The drug resistance of these bacteria has been on the increase since the 1980s, leeding to their multi-drug resistance. Selective pressure, present mainly in the hospital environment, contributed to this phenomenon. However, also outside the hospital environment selective pressure comes into play, namely the use of antibiotics as promoters of growth in
Katarzyna Talaga-Ćwiertnia,
Małgorzata Bulanda
Postępy Mikrobiologii - Advancements of Microbiology, Volume 57 , ISSUE 3, 244–250
Short Communication | 07-June-2016
Marek Selwet,
Mariola Galbas,
Ryszard Słomski,
Tomasz Cłapa,
Filip Porzucek
Polish Journal of Microbiology, Volume 65 , ISSUE 2, 237–240
original-paper | 05-December-2019
III) than strains from non-hospitalized patients.
Table III
Drug resistance of Staphylococcus aureus strains isolated from ocular infections.
Antimicrobial category
Antimicrobial agent
Hospitalization n (%)
Total, N = 83
Yes, n = 61 (73.4%)
No, n = 22 (26.5%)
Aminoglycosides
Gentamicin
4 (6.5%)
1 (4.5%)
5 (6.0%)
Amikacin
5 (8.1%)
3 (13.6%)
8 (9.6%)
Tobramycin
9 (14.7%)
5 (22.7%)
14 (16.8%)
Neomycin
37 (60.6%)
11 (50.0%)
48 (57.8%)
Fluoroquinolones
Ciprofloxacin
4 (6.5
MARTA KŁOS,
MONIKA POMORSKA-WESOŁOWSKA,
DOROTA ROMANISZYN,
AGNIESZKA CHMIELARCZYK,
JADWIGA WÓJKOWSKA-MACH
Polish Journal of Microbiology, Volume 68 , ISSUE 4, 541–548
Case report | 11-March-2014
Walter Fröscher,
Alois Rauber
Journal of Epileptology, Volume 22 , ISSUE 1, 51–55
Original Paper | 02-April-2015
course of disease were extracted from patients' charts. Drug resistant epilepsy was classified according to four definitions and the time until fulfillment of criteria compared. Results. Mean time to fulfillment of criteria of drug resistant epilepsy ranged from 11.8 (standard deviation (SD) 9.8) to 15.6 years (SD 11.3). Time to drug resistance was significantly longer applying the only definition, requiring failure of three antiepileptic drugs (AEDs) (Canada definition), whereas time to
Alexandra Rohracher,
Judith Dobesberger,
Claudia A. Granbichler,
Julia Höfler,
Giorgi Kuchukhidze,
Martin Ortler,
Iris Unterberger,
Gerald Walser,
Aljoscha Thomschewski,
Eugen Trinka
Journal of Epileptology, Volume 23 , ISSUE 1, 39–44
original-paper | 06-April-2020
vulnerable populations across the world and remains a leading global public health problem. Treatment of drug-susceptible TB takes six months while treatment of rifampicin-resistant TB (RR-TB) and multidrug-resistant TB (MDR-TB) requires a long therapy for up to two years (WHO 2019).
Globally, an 85% successful treatment rate has been reported for drug-susceptible MTB. The emergence of drug resistance, however, still poses a threat to global efforts. The WHO estimated 10.4 million new TB cases consist of
SAJID ALI,
MUHAMMAD TAHIR KHAN,
ANWAR SHEED KHAN,
NOOR MOHAMMAD,
MUHAMMAD MUMTAZ KHAN,
SAJJAD AHMAD,
SADIQ NOOR,
ABDUL JABBAR,
CANTILLON DAIRE,
FARIHA HASSAN
Polish Journal of Microbiology, Volume 69 , ISSUE 2, 133–137
Original Paper | 10-December-2018
MARYAM LABIBZADEH,
GHOLAM ABBAS KAYDANI,
MOHAMMAD SAVARI,
ALIREZA EKRAMI
Polish Journal of Microbiology, Volume 67 , ISSUE 4, 401–406
Original Paper | 10-December-2018
antituberculous drugs most commonly used in the treatment of mycobacterial infections in humans. For drug susceptibility tests, drugs such as isoniazid, rifampicin, streptomycin, ethambutol, ofloxacin, capreomycin, cycloserine and ethionamide were used. A high degree of drug resistance was demonstrated, particularly in Mycobacterium avium. Isolates of Mycobacterium xenopi showed a relatively good susceptibility to the drugs tested. The drug resistance of Mycobacterium genavense has not been determined, but
ALEKSANDRA LEDWOŃ,
AGNIESZKA NAPIÓRKOWSKA,
EWA AUGUSTYNOWICZ- KOPEĆ,
PIOTR SZELESZCZUK
Polish Journal of Microbiology, Volume 67 , ISSUE 4, 487–492
original-paper | 03-September-2019
. For HBV infection, the prevalence rate ranges from 1.2% (160/13 892) (Arikan et al. 2016) to 1.35% (339/25 442) (Guler et al. 2018). For Southern Cyprus, this rate was given as 0.77% and 1.01% (Altindis et al. 2016). Although there are few studies regarding the prevalence, up to now, there has been no publication on drug resistance in patients infected with HBV in Northern Cyprus (Altindis et al. 2006; Suer et al. 2014). Therefore, we aimed to show the presence of resistance mutations and their
AYSE ARIKAN,
MURAT SAYAN,
TAMER SANLIDAG,
KAYA SUER,
SINEM AKCALI,
MERYEM GUVENIR
Polish Journal of Microbiology, Volume 68 , ISSUE 3, 317–322
Article | 24-March-2021
Edyta Mazur,
Maria Jolanta Chmiel
Postępy Mikrobiologii - Advancements of Microbiology, Volume 60 , ISSUE 1, 77–89
research-article | 30-November-2020
stanowi stresor dla drobnoustrojów [48, 50].
Szczepy P. aeruginosa, szczególnie szpitalne, charakteryzuje wieloraka oporność na antybiotyki i środki dezynfekcyjne [36, 155, 157, 166]. Pałeczki te wykazują naturalną oporność na wiele antybiotyków, niektóre beta-laktamy (penicyliny, cefalosporyny I i II generacji), makrolidy tetracykliny, trimetoprim-sulfametoksazol [36, 60, 155]. Przyczyną tego jest zwiększona ekspresja genów kodujących pompy wyrzutu typu MDR (multi-drug resistance), modyfikacje miejsc
Kamila Korzekwa,
Kamil Sobolewski,
Bartłomiej Sobolewski
Advancements of Microbiology – Postepy Mikrobiologii, Volume 60 , ISSUE 4, 281–298
original-paper | 29-May-2020
-tuberculosis drug resistance remains a significant problem. Of the primary anti-tuberculosis drugs, isolates showing at least isoniazid (INH) and rifampin (RIF) resistance are defined as Multiple Drug-Resistant Tuberculosis (MDR-TB) (WHO 2019).
In this study, we aimed to document Mycobacterium species isolated in a large metropolitan tertiary care hospital in Turkey. The laboratory procedures used to isolate the organisms were also compared. Similarly, the resistance rates to the 1st-line anti-tuberculosis
BILGE SUMBUL,
MEHMET ZIYA DOYMAZ
Polish Journal of Microbiology, Volume 69 , ISSUE 2, 185–191
original-paper | 22-October-2019
) are observed, and HBV is characterized by a significant degree of genetic heterogeneity (Kostaki et al. 2018). The HBV genome encloses four partially overlapping open reading frames, which are PreS1/S2/S, PreC/C, P, and X encoding seven different proteins. Most significantly, Reverse Transcriptase (RT) and HBsAg frames overlap at RT amino acid 8–236, with HBsAg frameshift downstream by one nucleotide. Therefore, it indicates that mutations in these specific areas might result in drug resistance
UNAL SUMER,
MURAT SAYAN
Polish Journal of Microbiology, Volume 68 , ISSUE 4, 449–456
Original Paper | 10-December-2018
MIKOŁAJ MICHNO,
ANTONI SYDOR,
MARTA WAŁASZEK,
WŁADYSŁAW SUŁOWICZ
Polish Journal of Microbiology, Volume 67 , ISSUE 4, 517–524
Short Communication | 30-March-2017
Marcin Ciszewski,
Tomasz Czekaj,
Eligia M. Szewczyk
Polish Journal of Microbiology, Volume 66 , ISSUE 1, 119–123
research-paper | 12-August-2019
Jarosław Bryda,
Mirosław Zagaja,
Aleksandra Szewczyk,
Marta Andres-Mach
Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 2, 126–132
mini-review | 27-December-2020
different genome regions. These regions may encode for polymerase, surface antigen, core/precore promoter, and comprise the X genes that significantly influence HBsAg expression and progression of HCC (Shaha et al. 2018; Arikan et al. 2019). Additionally, due to the complete overlapping of pol and S genes, drug resistance and nucleos(t)ide resistance mutations occurring in the pol gene can lead to changes in its product HBsAg (Kırdar et al. 2019).
The mutations in the gene C that encode for precore and
MERYEM GUVENIR,
AYSE ARIKAN
Polish Journal of Microbiology, Volume 69 , ISSUE 4, 391–399
minireview | 24-February-2021
drugs, they failed to provide satisfying treatment for invasive aspergillosis patients. Notably, the clear side effects of antifungal drugs such as amphotericin B’s kidney toxicity and the potential hepatotoxicity of itraconazole discouraged their clinical use. Although voriconazole had better penetration than amphotericin B and itraconazole, it might cause temporary hepatotoxicity. In addition to the side effects of antifungal drugs, drug resistance and high cost also greatly hindered the use of
XIANG GU,
YAN-HONG HUA,
YANG-DONG ZHANG,
DI BAO,
JIN LV,
HONG-FANG HU
Polish Journal of Microbiology, Volume 70 , ISSUE 1, 3–11
research-article | 12-January-2022
1.
Introduction
According to the World Health Organization (WHO), the growing drug resistance of microorganisms is one of the top ten threats to humanity. In 2017, the WHO published a special report containing a list of pathogens for which the search for new therapeutic options is a priority, due to the increasingly limited range of antibiotics that can be used to treat infections caused by them [121]. Twelve pathogens were entered on the list, divided into 3 categories according to the urgency
Joanna Krajewska,
Agnieszka Ewa Laudy
Advancements of Microbiology – Postepy Mikrobiologii, Volume 60 , ISSUE 4, 249–264
original-paper | 05-December-2019
Introduction
Staphylococcus aureus infection and drug resistance problems have caused increasing public health problems. The increase in antimicrobial resistance coupled with intracellular infection makes this bacteria the third-largest threat to human health according to the WHO (Lowy 1998; Demon et al. 2012). MRSA is of particular concern because of its ability to spread extensively and rapidly, along with its multi-drug resistance to β-lactam and aminoglycoside antibiotics (Boucher et al
WENJING LUAN,
XIAOLEI LIU,
XUEFEI WANG,
YANAN AN,
YANG WANG,
CHAO WANG,
KESHU SHEN,
HONGYUE XU,
SHULIN LI,
MINGYUAN LIU,
LU YU
Polish Journal of Microbiology, Volume 68 , ISSUE 4, 477–491
original-paper | 08-September-2020
. 2017; Ero et al. 2019).
In this study, we analyzed the resistance spectrum, and the MIC levels of clinical P. aeruginosa isolates to commonly used in the clinic antibiotics and further analyzed the molecular mechanisms of the bacteria’s resistance to macrolides. Understanding the molecular mechanisms of drug resistance will help clinicians treat infectious diseases and prevent the spread of resistance more effectively.
Experimental
Materials and Methods
Bacterial strains collection, genomic DNA
QING CHEN,
WEI LU,
DANYING ZHOU,
GUOTONG ZHENG,
HONGMAO LIU,
CHANGRUI QIAN,
WANGXIAO ZHOU,
JUNWAN LU,
LIYAN NI,
QIYU BAO,
AIFANG LI,
TENG XU,
HAILI XU
Polish Journal of Microbiology, Volume 69 , ISSUE 3, 349–356
original-paper | 28-June-2019
provides useful information for prevention and helps clinicians prescribe the effective antibiotic therapy (Ventola 2015), as well as optimize the use of antibiotics, which has become one of the most important parts of drug resistance control (Lafaurie et al. 2012; Wang et al. 2018). In this study, the significant changes and trends in antibiotic resistance of clinically important pathogens isolated from a general hospital in Zhengzhou, Henan Province, China, from 2011 to 2016 were described to provide
TINGTING MAO,
HUIJUAN ZHAI,
GUANGCAI DUAN,
HAIYAN YANG
Polish Journal of Microbiology, Volume 68 , ISSUE 2, 225–232
original-paper | 03-September-2019
pathogenicity determinants of C. glabrata sensu lato is their ability to adhere to abiotic and biotic surfaces, to form biofilm on both surfaces, and to secrete phospho- and lipases, hemolysins, and other cytotoxic enzymes. (Tamura et al. 2007; Silva et al. 2012; Rodrugues et al. 2014).
Little is known about the drug resistance of the C. glabrata species complex. Some studies suggest that the new species within the complex may be more resistant to antifungals than C. glabrata sensu stricto (Tamura et al
MAGDALENA SIKORA,
ROBERT KUTHAN,
KATARZYNA PISKORSKA-MALOLEPSZA,
MARLENA GOLAS-PRADZYNSKA,
DARIUSZ DOMAŃSKI,
EWA AUGUSTYNOWICZ-KOPEĆ,
EWA SWOBODA-KOPEC
Polish Journal of Microbiology, Volume 68 , ISSUE 3, 303–308
Review Paper | 25-January-2016
remitting, uninterrupted by relapse (in 48%); a remitting-relapsing course (interrupted by relapses, in terminal remission) (19%); worsening course (early or late remission followed by drug-resistant epilepsy) (14%); and never in ≥5-year remission (drug resistance) (19%) The medical and social outcomes based on my unique, five decades followed cohort show that most subjects are in 10-year remission without medications, which is the definition of resolved epilepsy. Normal or subnormal IQ, non
Matti Sillanpää
Journal of Epileptology, Volume 24 , ISSUE 1, 25–39