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  • Acta Neurobiologiae Experimentalis

 

Original Paper

Additive interactions between retigabine and oxcarbazepine in the chimney test and the model of generalized tonic-clonic seizures in mice

Introduction. Patients with pharmacoresistant epilepsy are usually treated with two or more antiepileptic drugs (AEDs). The search for therapeutically efficacious AED combinations is still a challenging issue for clinicians and epileptologists throughout the world. Aim. To determine the interaction profile for the combination of retigabine (RTG) and oxcarbazepine (OXC) in both, the model of tonic-clonic seizures, the maximal electroshock (MES)-induced seizure model and chimney test (motor

Mirosław Zagaja, Barbara Miziak, Katarzyna Załuska, Paweł Marzęda, Bartłomiej Drop, Karolina Załuska-Patel, Grażyna Ossowska, Stanisław J. Czuczwar, Jarogniew J. Łuszczki

Journal of Epileptology , ISSUE 2, 87–94

Original Paper

Adenosine receptor agonists differentially affect the anticonvulsant action of carbamazepine and valproate against maximal electroshock test-induced seizures in mice

-NECA and A 1 (preferentially) and A2 – 2-chloroadenosine. Their possible anticonvulsant effects were studied in a threshold electroconvulsive test for maximal electroconvulsions. The protective activity of AEDs alone or in combinations with adenosine agonists was evaluated in the form of their respective ED50 values necessary to protect 50% of mice against tonic extension of the hind limbs, following maximal electroshock, delivered through ear electrodes. The specificity of interactions

Mirosław Jasiński, Magdalena Chrościńska-Krawczyk, Stanisław J. Czuczwar

Journal of Epileptology , ISSUE 1-2, 21–29

research-paper

Protective effects of M8-B, a TRPM8 antagonist, on febrile- and pentylenetetrazol-induced seizures

channel in epileptogenesis has not yet been evaluated. Considering the physiological and pharmacological features of the TRPM8 channel, we aimed to evaluate the effect of a selective TRPM8 antagonist in different experimental models of seizure. METHODS Eight-day-old male Wistar rat pups (13–15 g) were used for induction of febrile seizures. Male albino mice (25–30 g) were used for PTZ- and electroshock-induced convulsions. The animals were housed under standard conditions (22–25°C and 12 h light

Nazanin Zandi, Nosaibeh Riahi Zaniani, Ali Moghimi, Ali Roohbakhsh

Acta Neurobiologiae Experimentalis , ISSUE 1, 86–91

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