research-article
exercise session.
Behavioral tests
Both behavioral tests were carried out in the early morning (09:00-12:00) on the day after the final exercise session. The open field test (OFT) always preceded elevated plus maze (EPM), and there was no break between tests. The test room was kept silent under consistent light (110 lux, warm light). The observer remained outside during the test session. A hidden camera recorded the entire test, and the tapes were analyzed blindly. Test setups were cleaned with 70
Hasan Caliskan,
Firat Akat,
Goktug Omercioglu,
Gulbahar Bastug,
Hakan Ficicilar,
Metin Bastug
Acta Neurobiologiae Experimentalis , 1–11
Research paper
dark compartment of the apparatus. In the IA test phase (one week later) the same procedure took place, but without shock. Complementary measures were obtained by evaluating all the animals in an elevated plus maze (locomotor activity and emotionality) and on a hot plate (analgesia). IA learning was confirmed in all groups except the stressed+saline group, which was the only one that exhibited higher anxiety levels. No variations were observed in either locomotor activity or analgesia. In
Aranzazu Duque,
Concepción Vinader-Caerols,
Santiago Monleón
Acta Neurobiologiae Experimentalis , ISSUE 3, 225–233
Research paper
infusion or as twice-daily treatment, eltoprazine produced a decrease in food intake and body weight at doses leading to 200–500 nM plasma concentrations.
In the elevated plus maze eltoprazine increased anxiety-like behavior. On the other hand, it induced a clear-cut anxiolytic effect in context fear conditioning test starting at ca. 0.3 mg/kg, and failed to produce any significant effect in fear potentiated startle test. Regarding adverse effects, eltoprazine was found to produce hypothermia starting
Andreas Gravius,
Andrzej Dekundy,
Anita Vanaga,
Lutz Franke,
Wojciech Danysz
Acta Neurobiologiae Experimentalis , ISSUE 1, 77–85
Research paper
established (i.e., treatment). A battery of behavioral and cognitive tests were performed, including open-field, elevated plus maze, Porsolt’s forced swim, and Morris’ water maze, to evaluate anxietyand depression-like behaviors, and learning and memory. Results showed that chia supplementation was ineffective against Alzheimer’s-related anxiety, whereas depression-like behaviors were attenuated with both pretreatment and treatment. There was no improvement in learning and memory with chia treatment
Yasemin Bilgic,
Enver Ahmet Demir,
Nilufer Bilgic,
Hatice Dogan,
Okan Tutuk,
Cemil Tumer
Acta Neurobiologiae Experimentalis , ISSUE 4, 322–331
research-paper
to behavioral analysis by monitoring depressogenic and anxiogenic behaviors in the forced swim test (FST) and light/dark transition (LDT) test, respectively. Memory function was assessed using the elevated plus maze (EPM), Morris water maze (MWM) and novel object recognition (NOR) task. Administration of nuts was continued until the end of the behavioral analysis. Rats were decapitated after behavioral analysis to collect brain samples, which were stored at −20°C for analysis of biogenic amine
Zehra Batool,
Faiza Agha,
Saiqa Tabassum,
Tuba Sharf1 Batool,
Rafat Ali Siddiqui,
Saida Haider
Acta Neurobiologiae Experimentalis , ISSUE 2, 169–183
research-article
animals in opaque standard laboratory cages. Two groups were used as a control, in which icv injections of citrate buffer were administered (control group) and the other two groups received streptozotocin via icv (STZ group). One control and one STZ group were submitted to the elevated plus maze (EPM) and had their brains removed one month after the injections (phase 1). Four months later, the other two groups were submitted to the same procedure to evaluate short and long-term effects of STZ
Gabrielle Pfutzenreuter,
Kenny Nieradka,
Márcia Regina Pincerati,
Ilton Santos da Silva
Acta Neurobiologiae Experimentalis , ISSUE 2, 160–169