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research-article | 31-July-2020

Aerobic exercise has an anxiolytic effect on streptozotocin-induced diabetic rats

was also applied after the completion of the exercise session. Behavioral tests Both behavioral tests were carried out in the early morning (09:00-12:00) on the day after the final exercise session. The open field test (OFT) always preceded elevated plus maze (EPM), and there was no break between tests. The test room was kept silent under consistent light (110 lux, warm light). The observer remained outside during the test session. A hidden camera recorded the entire test, and the tapes were

Hasan Caliskan, Firat Akat, Goktug Omercioglu, Gulbahar Bastug, Hakan Ficicilar, Metin Bastug

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 3, 245–255

Research paper | 01-August-2017

Effects of social stress and clomipramine on emotional memory in mice

dark compartment of the apparatus. In the IA test phase (one week later) the same procedure took place, but without shock. Complementary measures were obtained by evaluating all the animals in an elevated plus maze (locomotor activity and emotionality) and on a hot plate (analgesia). IA learning was confirmed in all groups except the stressed+saline group, which was the only one that exhibited higher anxiety levels. No variations were observed in either locomotor activity or analgesia. In

Aranzazu Duque, Concepción Vinader-Caerols, Santiago Monleón

Acta Neurobiologiae Experimentalis, Volume 76 , ISSUE 3, 225–233

Research paper | 06-February-2018

Further pharmacological characterization of eltoprazine: focus on its anxiolytic, anorexic, and adverse-effect potential

infusion or as twice-daily treatment, eltoprazine produced a decrease in food intake and body weight at doses leading to 200–500 nM plasma concentrations. In the elevated plus maze eltoprazine increased anxiety-like behavior. On the other hand, it induced a clear-cut anxiolytic effect in context fear conditioning test starting at ca. 0.3 mg/kg, and failed to produce any significant effect in fear potentiated startle test. Regarding adverse effects, eltoprazine was found to produce hypothermia starting

Andreas Gravius, Andrzej Dekundy, Anita Vanaga, Lutz Franke, Wojciech Danysz

Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 1, 77–85

Research paper | 15-January-2019

Detrimental effects of chia (Salvia hispanica L.) seeds on learning and memory in aluminum chloride-induced experimental Alzheimer’s disease

established (i.e., treatment). A battery of behavioral and cognitive tests were performed, including open-field, elevated plus maze, Porsolt’s forced swim, and Morris’ water maze, to evaluate anxietyand depression-like behaviors, and learning and memory. Results showed that chia supplementation was ineffective against Alzheimer’s-related anxiety, whereas depression-like behaviors were attenuated with both pretreatment and treatment. There was no improvement in learning and memory with chia treatment

Yasemin Bilgic, Enver Ahmet Demir, Nilufer Bilgic, Hatice Dogan, Okan Tutuk, Cemil Tumer

Acta Neurobiologiae Experimentalis, Volume 78 , ISSUE 4, 322–331

research-paper | 30-November-2018

Prevention of cadmium-induced neurotoxicity in rats by essential nutrients present in nuts

to behavioral analysis by monitoring depressogenic and anxiogenic behaviors in the forced swim test (FST) and light/dark transition (LDT) test, respectively. Memory function was assessed using the elevated plus maze (EPM), Morris water maze (MWM) and novel object recognition (NOR) task. Administration of nuts was continued until the end of the behavioral analysis. Rats were decapitated after behavioral analysis to collect brain samples, which were stored at −20°C for analysis of biogenic amine

Zehra Batool, Faiza Agha, Saiqa Tabassum, Tuba Sharf1 Batool, Rafat Ali Siddiqui, Saida Haider

Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 2, 169–183

research-article | 15-October-2020

RhoA/Rock2/Limk1/cofilin1 pathway is involved in attenuation of neuronal dendritic spine loss by paeonol in the frontal cortex of D-galactose and aluminum-induced Alzheimer’s disease-like rat model

blind to the rats of the different treatment groups. The device was cleaned with 70% ethanol thoroughly after each trial. Elevated plus maze test (EPMT) The EPMT was commonly used to assess anxiety behaviors (Pellow et al., 1985). The high cross apparatus consisted of four black arms (50 cm × 10 cm) and a central square platform (10 cm × 10 cm). Two of the arms were closed arms with walls (40 cm height), called the closed arms. And the other two arms were open without walls, called the open arms

Fei Han, Hui Xu, Jun-Xian Shen, Chuan Pan, Zong-Hao Yu, Jing-Jing Chen, Xiu-Ling Zhu, Ya-Fei Cai, Ya-Ping Lu

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 3, 225–244

research-article | 07-July-2020

Intracerebroventricular streptozotocin induces behavioral impairments and increases short-term C3 gene expression in the hippocampus of Wistar rats

animals in opaque standard laboratory cages. Two groups were used as a control, in which icv injections of citrate buffer were administered (control group) and the other two groups received streptozotocin via icv (STZ group). One control and one STZ group were submitted to the elevated plus maze (EPM) and had their brains removed one month after the injections (phase 1). Four months later, the other two groups were submitted to the same procedure to evaluate short and long-term effects of STZ

Gabrielle Pfutzenreuter, Kenny Nieradka, Márcia Regina Pincerati, Ilton Santos da Silva

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 2, 160–169

research-article | 30-November-2019

Alteration of the neurogenesis and long term potential of olfactory bulb in an animal model of PTSD

under standard condition (12-12 h light/dark schedule, the humidity of 54±2% and temperature 22±2°C) and free accessibility to food and water (ad libitum). Animal examinations were carried out in accordance with procedures approved by the Committee on Animal Research of Mashhad University of Medical Sciences. Rats were randomly divided into two groups: experimental (PTSD) and control group (14 rats in each group). Elevated plus maze (EPM), open field (OF), and electrophysiological studies were

Sadegh Rahimi, Mohadeseh Ragerdikashani, Farimah Beheshti, Faride Baghishani, Mahmoud Hosseini, Nikoo Saeedi, Motahareh Mirdoosti, Sajad Sahab Negah

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 4, 344–352

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