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Original Paper

Emodin Reduces the Activity of (1,3)-β-D-glucan Synthase from Candida albicans and Does Not Interact with Caspofungin

echinocandins causes defects in fungal cell integrity. In the present study, similar activity of emodin (6-methyl-1,3,8-trihydroxyanthraquinone) has been revealed. Many reports have already shown the antifungal potential of this pleiotropic molecule, including its activity against C. albicans. The aim of this report was to evaluate the activity of emodin towards a new molecular target, i.e. (1,3)-β-D-glucan synthase isolated from Candida cells. Moreover, given the identical mechanism of the activity of both

MONIKA JANECZKO

Polish Journal of Microbiology , ISSUE 4, 463–470

original-paper

Chemical Composition of Aspergillus creber Extract and Evaluation of its Antimicrobial and Antioxidant Activities

fermentation broth, the secondary metabolites of A. creber were extracted, through EtOAc, filtered and concentrated in vacuo to give EAF, which was subjected to UHPLC-MS/MS analysis. On the basis of the fungal metabolites list established by (Lehner et al. 2011), molecular mass data, MS/MS analysis and references, five known fungal metabolites were tentatively identified as asperlactone (1), emodin (5), sterigmatocystin (7), deoxybrevianamide E (9) and norsolorinic acid (10) (Table I) whereas five

AFAF SAKHRI, NOREDDINE KACEM CHAOUCHE, MARIA ROSARIA CATANIA, ALBERTO RITIENI, ANTONELLO SANTINI

Polish Journal of Microbiology , ISSUE 3, 309–316

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