feature of Brucella is the ability to survive and multiply within both phagocytic and non-phagocytic cells. Brucella does not produce classical virulence factors: exotoxin, cytolisins, exoenzymes, plasmids, fimbria, and drug resistant forms. Major virulence factors are: lipopolysaccharide (LPS), T4SS secretion system and BvrR/BvrS system, which allow interaction with host cell surface, formation of an early, late BCV (Brucella Containing Vacuole) and interaction with endoplasmic reticulum (ER) when
Polish Journal of Microbiology , ISSUE 2, 151–161
endoplasmic reticulum followed by accumulation in mitochondria, which likely causes a decrease in mitochondrial membrane potential.
Tatsiana G. Dubouskaya,
Sviatlana V. Hrynevich,
Tatsiana V. Waseem,
Sergei V. Fedorovich
Acta Neurobiologiae Experimentalis , ISSUE 4, 343–351