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Mini Review

Brucella – Virulence Factors, Pathogenesis and Treatment

feature of Brucella is the ability to survive and multiply within both phagocytic and non-phagocytic cells. Brucella does not produce classical virulence factors: exotoxin, cytolisins, exoenzymes, plasmids, fimbria, and drug resistant forms. Major virulence factors are: lipopolysaccharide (LPS), T4SS secretion system and BvrR/BvrS system, which allow interaction with host cell surface, formation of an early, late BCV (Brucella Containing Vacuole) and interaction with endoplasmic reticulum (ER) when


Polish Journal of Microbiology , ISSUE 2, 151–161

Research paper

Calcium release from intracellular stores is involved in mitochondria depolarization after lowering extracellular pH in rat brain synaptosomes

endoplasmic reticulum followed by accumulation in mitochondria, which likely causes a decrease in mitochondrial membrane potential.

Tatsiana G. Dubouskaya, Sviatlana V. Hrynevich, Tatsiana V. Waseem, Sergei V. Fedorovich

Acta Neurobiologiae Experimentalis , ISSUE 4, 343–351

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