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  • Acta Neurobiologiae Experimentalis

 

research-paper

Protective effects of M8-B, a TRPM8 antagonist, on febrile- and pentylenetetrazol-induced seizures

the brain. Dysfunction in inhibitory synaptic transmission mediated by gamma-aminobutyric acid (GABA), enhanced glutamatergic excitatory synaptic mechanisms, increases in calcium flow, and the intensification of spontaneous neuronal firing are the primary mechanisms responsible for seizure episodes. Fever has been implicated as the main cause of seizures in infants and young children with fever leading to febrile seizure in one out of every 20–50 children (Dube et al., 2007). Generally, febrile

Nazanin Zandi, Nosaibeh Riahi Zaniani, Ali Moghimi, Ali Roohbakhsh

Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 1, 86–91

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