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Article | 01-March-2015


One of the most profound use of ultrasound imaging is fetal growth monitoring. Conventionally, physicians will perform manual measurements of several parameters of the ultrasound images to draw some conclusion of the fetal condition by manually annotating the fetal images on the ultrasound device interface. However, performing manual annotation of fetal images will require significant amount of time considering the number of patients an obstetrician can have. In this paper, an integrated

Wisnu Jatmiko, Ikhsanul Habibie, M. Anwar Ma’sum, Robeth Rahmatullah, I Putu Satwika

International Journal on Smart Sensing and Intelligent Systems, Volume 8 , ISSUE 1, 697–719

Review Article | 30-March-2018

Current knowledge on the use of ultrasound measurements of fetal soft tissues for the assessment of pregnancy development

Ultrasonography, with its detailed imaging of the fetus, is very widely used in obstetrics. The primary aim of ultrasound scanning in pregnancy is to limit the risk of obstetric complications by early detection of abnormalities, such as intrauterine growth restriction and macrosomia. Currently, morphometric formulae are used for estimating fetal weight. They utilize basic biometric parameters. However, Hadlock formula, used for fetal weight estimation, has an error rate of 20%. For this reason

Aleksandra Warska, Anna Maliszewska, Anna Wnuk, Beata Szyszka, Włodzimierz Sawicki, Krzysztof Cendrowski

Journal of Ultrasonography, Volume 18 , ISSUE 72, 50–55

research-article | 15-June-2020

Fetal ultrasound estimated weight and correlation to Brazilian newborn weight

Introduction Adverse events in the process of fetal growth can lead to consequences at later times and the extent of the damage depends on the nature, duration and severity. Two crucial determinants of fetal growth are the pregnancy duration and the fetal weight at a specific gestational age(1). As weight is easy to measure at birth, it is used as an indicator of fetal growth, and is included in the comparative statistics on perinatal health improvements. There is a wide variety of normal birth

Roberto Noya Galluzzo, Alberto Trapani, Heron Werner, Renato Augusto Moreira de Sá, João Carlos Xikota, Edward Araujo, Maria Marlene de Souza Pires

Journal of Ultrasonography, Volume 20 , ISSUE 81, 106–110

Article | 01-March-2015


This paper proposed a system for detecting and approximating of a fetus in an ultrasound image. The fetal organs in the ultrasound image are detected using Multi Boundary Classifier based Adaboost.MH. The results of the fetal detection is then approximated Randomized Hough Transform and the whole showed a mean accuracy of 95.80%. The mean of the Hamming Error 0.019 and the Kappa coefficient value reaches 0.890.The proposed method has the best performancefor fetal organ detection. This is proven

M. Anwar Ma’sum, Wisnu Jatmiko, Budi Wiweko, Anom Bowolaksono

International Journal on Smart Sensing and Intelligent Systems, Volume 8 , ISSUE 1, 720–748

review-article | 31-December-2019

Fetal cardiac function by three-dimensional ultrasound using 4D-STIC and VOCAL – an update

Introduction Congenital heart disease (CHD) occurs in one to two newborns per 100 live births and is an important cause of perinatal morbidity and mortality(1–4). Prenatal screening and diagnosis of anatomical and functional heart malformations are possible by ultrasonography and fetal echocardiography, allowing for planning of delivery and, in some cases, prenatal therapy, favoring the postnatal prognosis of CHD(5–7). Cardiac function is routinely evaluated in fetuses with anatomical

Nathalie Jeanne Bravo-Valenzuela, Alberto Borges Peixoto, Milene Carvalho Carrilho, Ana Letícia Siqueira Pontes, Caroline Cevante Chagas, Christiane Simioni, Edward Araujo Júnior

Journal of Ultrasonography, Volume 19 , ISSUE 79, 287–294

Research Article | 31-March-2017

Fetal biometric parameters: Reference charts for a non-selected risk population from Uberaba, Brazil

Objective Objective To establish reference charts for fetal biometric parameters in a non-selected risk population from Uberaba, Southeast of Brazil. Methods Methods A retrospective cross-sectional study was performed among 5656 non-selected risk singleton pregnant women between 14 and 41 weeks of gestation. The ultrasound exams were performed during routine visits of second and third trimesters. Biparietal diameter (BPD) was measured at the level of the thalami and cavum septi pellucidi. Head

Alberto Borges Peixoto, Taciana Mara Rodrigues da Cunha Caldas, Fernando Felix Dulgheroff, Wellington P. Martins, Edward Araujo Júnior

Journal of Ultrasonography, Volume 17 , ISSUE 68, 23–29

research-article | 15-June-2020

Gradual diagnosis and clinical importance of prenatally detected persistent left superior vena cava with absent right superior vena cava – a case report and literature review

Introduction At week 4 of gestation, the blood of the upper half of a fetal body is drained by the bilateral symmetrically arranged anterior cardinal veins. By week 8 they connect by an oblique anastomosis (future left brachiocephalic or innominate vein) and the part of the left anterior cardinal vein regresses. Persistent left superior vena cava (PLSVC) seems to be a remnant of this regressed vessel(1). Achiron et al. proposed a classification of fetal venous system anomalies, where PLSVC is

Oskar Sylwestrzak, Maria Respondek-Liberska

Journal of Ultrasonography, Volume 20 , ISSUE 81, e146–e150

research-paper | 12-August-2019

Prenatal ethanol intoxication and maternal intubation stress alter cell survival and apoptosis in the postnatal development of rat hippocampus

INTRODUCTION Ethyl alcohol (ethanol) is a well-known teratogen that impairs brain development (Ward and Wainwright, 1989; Miller and Montgomery, 1992; Michaelis and Michaelis, 1994). The cells in the central nervous system are highly vulnerable to adverse effects of ethanol and fetal ethanol exposure may cause a massive wave of apoptotic neurodegeneration in many different regions of the developing human brain. (Ikonomidou et al., 2000; Light et al., 2002; Goodlett et al., 2005). The neocortex

Birsen Elibol, Merve Beker, Cigdem Dilek Sahbaz, Ulkan Kilic, Ewa Jakubowska-Doğru

Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 2, 133–147

Case report | 06-December-2020

Case report: mixed-field agglutination in a patient with a weak D antigen presenting as a possible fetal-maternal hemorrhage

A gravida 1, para O, 17-year-old black female was found on prenatal testing to be group O, Du+, the latter test showing many unagglutinated cells. Because of the mixed-field appearance, the patient was thought initially to have bad a fetal-maternal hemorrhage. Additional red cell typings were performed, but no other apparent mixed-field reactions were observed. The Kleihauer-Betke test and hemoglobin electrophoresis indicated that the mixed-field agglutination was not due to a fetal-maternal

Phyllis J. Unger

Immunohematology, Volume 8 , ISSUE 3, 77–78

research-article | 31-December-2019

Comparing intrapartum ultrasound and clinical examination in the assessment of fetal head position in African women

Introduction The fetal head position plays an important role in the mode of delivery and is one of the known predictors of labor outcome. Particularly, the persistent occiput posterior position might be associated with prolonged labor and operative delivery(1–3). Undiagnosed occiput posterior positions increase the risk of perineal lacerations and neonatal injuries in the process of delivery(4). An accurate method for determining the occiput position is therefore useful in assessing the

Yaw A. Wiafe, Bill Whitehead, Heather Venables, Edward T. Dassah

Journal of Ultrasonography, Volume 19 , ISSUE 79, 249–254

Case report | 30-June-2017

A reminder of peristalsis as a useful tool in the prenatal differential diagnosis of abdominal cystic masses

With routine antenatal ultrasound and recent advances in ultrasound technology, fetal intraabdominal cystic masses are recognized more often and are better characterized than in the past. They may be classified as solid and cystic, and may originate from multiple structures. When considering the extensive differential diagnosis of cystic masses, the observation of peristalsis narrows the possibilities to the gastrointestinal tract. To find this feature on ultrasound, the examiner must expressly

Eugenio O. Gerscovich, Simran Sekhon, Thomas W. Loehfelm, Sandra L. Wootton-Gorges, Adam Greenspan

Journal of Ultrasonography, Volume 17 , ISSUE 69, 129–132

research-article | 30-November-2020

Liver herniation into the pericardium mimicking a pericardial tumor: unusual presentation of trisomy 13

Case description A 34-year-old gravida 2 para 1 was referred for fetal echocardiography following a diagnosis of a hyperechogenic focus in the left ventricle at 22 weeks of gestation. The patient was in her second single low-risk pregnancy. Her first daughter was healthy. A combined first trimester screening test was performed at 13 weeks. Fetal nuchal translucency (NT) equaled 1.8 mm for a crown-rump length (CRL) 72 mm, with a fetal heart rate (FHR) of 164/min, and no tricuspid valve

Joanna Szymkiewicz-Dangel, Maria Magdalena Hussey

Journal of Ultrasonography, Volume 21 , ISSUE 87, 353–356

Article | 22-November-2020

Development of a flow cytometric test for the detection of D-positive fetal cells after fetomaternal hemorrhage and a survey of the prevalence in D-negative women

A sensitive test for the presence of D-positive fetal red blood cells (RBCs) in the maternal circulation of D-negative women has been developed. It was used to investigate the possibility that the occasional failure in preventing alloimmunization might be due to the administration of inadequate amounts of prophylactic anti-D Rh immune globulin. The standard dose in Australia contains 125µg of antibody, and can suppress immunization by an estimated 6 mL of packed D-positive RBCs. A

Margaret Nelson, Hazel Popp, Kathy Horky, Cecily Forsyth, John Gibson

Immunohematology, Volume 10 , ISSUE 2, 55–59

Editorial | 13-September-2016

Intrapartum sonography – eccentricity or necessity?

numerous  studies documented high error rates of conventional obstetrical examination. Even an experienced physician makes a mistake in every third case of the fetal head descent and fontanelle position assessment. Nowadays, obstetrician’s role is not to strain for vaginal delivery at all costs,but to provide the patient in labor and her newborn with maximal safety. To achieve this objective, an obstetrician should distinguish between women who will deliver spontaneously and whose who require Cesarean

Marzena Dębska, Piotr Kretowicz, Romuald Dębski

Journal of Ultrasonography, Volume 15 , ISSUE 61, 125–136

Review | 14-March-2020

Laboratory methods for Rh immunoprophylaxis: a review

The recommended dose of Rh immune globulin for postpartum Rh immunoprophylaxis is based on an estimation of the volume of the fetomaternal hemorrhage, if any, measured as the percent of fetal RBCs in a sample of the D– mother’s blood. Laboratory methods for distinguishing fetal from maternal RBCs have been based on their different blood types (D+ versus D–) or predominant hemoglobin content (hemoglobin F versus hemoglobin A). We conducted a review of the medical literature

S. Gerald Sandler, Srividya Sathiyamoorthy

Immunohematology, Volume 26 , ISSUE 3, 92–103

Article | 16-October-2019

Anti-Vel alloimmunization and severe hemolytic disease of the fetus and newborn

The Vel red blood cell (RBC) antigen was first described in 1952.1 The antigen is ubiquitous in the general population, with only 0.04 percent of Caucasian individuals failing to exhibit expression.2 Only rare cases of anti-Vel–associated mild-to-moderate hemolytic disease of the fetus and newborn (HDFN) have been previously reported.3–7 The neonatal manifestation of HDFN in these cases was limited to hyperbilirubinemia requiring only phototherapy. No case of fetal anemia requiring prenatal

K.J. Moise, Y. Morales, M.F. Bertholf, S.N. Rossmann, Y. Bai

Immunohematology, Volume 33 , ISSUE 4, 152–154

case-report | 31-December-2019

Prenatal diagnosis of congenital megalourethra in the second trimester of pregnancy

Introduction Congenital megalourethra is typically characterized by the aplasia of penile erectile tissue, leading to abnormal dilation of the anterior urethra without structural obstruction(1,2). This terminology was first used in 1955 to describe an infant with abnormally enlarged penis and worsening renal function(2). In 1989, Benacerraf et al.(3) diagnosed megalourethra for the first time on fetal ultrasound. Congenital megalourethra is a rare condition. The prevalence is not known since

Do Duy Anh, Ha To Nguyen, Simon Meagher, Edward Araujo Júnior

Journal of Ultrasonography, Volume 19 , ISSUE 79, 302–304

Article | 14-October-2020

Neonatal alloimmune thrombocytopenia due to anti-HPA-5b (Bra)

Neonatal alloimmune thrombocytopenia (NAIT) results from maternal immunization against fetal platelet antigens and can occur during the first pregnancy. The most common complications of NAIT are neonatal thrombocytopenia, intracerebral hemorrhage, and fetal death. Most cases of NAIT in Causasians are caused by anti-HPA-1a (PlA1). Anti-HPA-5b (Bra) accounts for only 4.3 percent of all NAIT cases. NAIT due to anti-HPA-5b is thought to be milder and have fewer complications than NAIT caused by

Sally A. Campbell-Lee, Deirdre DeSantis-Parsons, R. Sue Shirey, Thomas S. Kickler

Immunohematology, Volume 19 , ISSUE 4, 127–131

Case report | 15-April-2020

Case report:moderate hemolytic disease of the newborn due to anti-G

Views expressed in this article are those of the author and do not reflect the official policy or position of the Department of the Navy, Department of Defense, or U.S.Government. The only previously published case of anti-G in a pregnant woman indicated that anti-G alone caused little, if any, fetal or neonatal hemolysis. This report describes an affected fetus with amnionitic fluid OD 450 absorbance values in the moderate zone of the Liley prediction graph who required prolonged phototherapy

Aaron R. Huber, George T. Leonard, Rita W. Driggers, Sakhone B. Learn, Colleen W. Gilstad

Immunohematology, Volume 22 , ISSUE 4, 166–170

Article | 12-October-2020


. monocytogenes wykazano, że dochodzi do degeneracji komórek syncytiotrofoblastu (na wskutek ostrego stanu zapalnego), co prawdopodobnie umożliwia transmisję patogenu na płód [55]. 3. Poród przedwczesny i waginoza Porodem przedwczesnym (PTD – preterm delivery) określa się urodzenie dziecka przed 37. tygodniem ciąży. W przypadku poronienia do porodu dochodzi przed 22. tygodniem. W USA za dolną granicę przyjmuje się 20. tydzień. Jeśli dojdzie do wewnątrzmacicznego obumarcia płodu (IUFD – intrauterine fetal

Dominik M. Matusiak

Postępy Mikrobiologii - Advancements of Microbiology, Volume 59 , ISSUE 3, 237–247

case-report | 25-June-2021

Severe perinatal hemolytic disease due to anti-e

Hemolytic disease of the fetus and newborn (HDFN) is an alloimmune condition in which shortened survival of the red blood cells (RBCs) of the fetus or the newborn is caused by maternal antibodies passing through the placenta and binding to the corresponding antigen on the fetal RBCs. The pathogenesis of HDFN is based on a blood group incompatibility between the mother and fetus, where the fetal RBCs have antigens of paternal origin that are lacking on the mother’s RBCs. If the mother has an

G. Soler-Noda, Y. Romero-Díaz, L. Orbeal-Aldama, S. Aquino-Rojas

Immunohematology, Volume 37 , ISSUE 2, 72–77

Case report | 29-December-2017

Fetal ultrasound: Early diagnosis and natural evolution of proximal femoral focal deficiency

Eugenio O. Gerscovich, Simran Sekhon, Thomas W. Loehfelm, Adam Greenspan

Journal of Ultrasonography, Volume 17 , ISSUE 71, 294–298

Case report | 17-November-2020

Case report: a pregnant woman with immune thrombocytopenic purpura and unusual red cell antibodies

Maternal immune thrombocytopenic purpura (ITP) may lead to fetal platelet destruction. This process is mediated by IgG platelet autoantibodies that cross the placenta. In this case, not only were platelet autoantibodies present, but red cell alloantibodies anti-E, anti-M, and anti-He were also present. Anti-E, present as an IgG antibody, crossed the placenta, but did not cause clinical problems in the E+ newborn, other than possible hyperbilirubinemia that was treated by phototherapy.

Carmela R. Nanton, Sharon M. Martin, Lloyd O. Cook, Patricia J. Larison

Immunohematology, Volume 11 , ISSUE 4, 153–155

Article | 15-April-2020

Update on HDFN: new information on long-standing controversies

Hemolytic disease of the fetus and newborn (HDFN) results from maternal IgG antibodies that cross the placenta to the fetal circulation during gestation and cause RBC destruction and complications before birth (HDF), or anemia and hyperbilirubinemia after birth (HDN), or both. In its most severe form,HDF produces hydrops fetalis,which is characterized by total body edema,hepatosplenomegaly,and heart failure and can lead to intrauterine death. Before discovery of Rh immunoglobulin (RhIG), HDFN

Anne F. Eder

Immunohematology, Volume 22 , ISSUE 4, 188–195

Case report | 01-December-2019

Possible suppression of fetal erythropoiesis by the Kell blood group antibody anti-Kpa

Michelle Tuson, Kim Hue-Roye, Karen Koval, Sherwin Imlay, Rajendra Desai, Gayatri Garg, Esam Kazem, Diane Stockman, Janis S. Hamilton, Marion E. Reid

Immunohematology, Volume 27 , ISSUE 2, 58–60

case-report | 31-December-2019

Prenatal diagnosis of congenitally corrected transposition of the great arteries

great arteries diagnosed in utero, focusing on the clues necessary to make the prenatal diagnosis during fetal cardiac ultrasound/echocardiography. Case report A 21-year-old secundigravida at 37 weeks of gestation was referred to a fetal cardiologist due to suspected transposition of the great arteries. She was a healthy pregnant woman, and there was no familial history of a congenital heart disease, infectious diseases or consumption of any drugs. Fetal echocardiography showed atrioventricular

Nathalie Jeanne Bravo-Valenzuela, Alberto Borges Peixoto, Edward Araujo Júnior

Journal of Ultrasonography, Volume 19 , ISSUE 79, 314–317

Case report | 16-October-2019

Management of pregnancy sensitized with anti-Inb with monocyte monolayer assay and maternal blood donation

Maternal red blood cell (RBC) alloantibodies can cause hemolytic disease of the fetus and newborn (HDFN). Although much is described about common antibodies associated with HDFN, management of a pregnancy complicated by a maternal rare antibody presents several challenges related to assessment of fetal anemia risk, availability of blood for transfusion to the mother and/or the fetus or newborn if needed, and planning for delivery in the case of maternal hemorrhage. Here we report the laboratory

Raj Shree, Kimberly K. Ma, Lay See Er, Meghan Delaney

Immunohematology, Volume 34 , ISSUE 1, 7–10

Article | 17-February-2021

K antigens on neonatal red blood cells blocked by anti-K with titer of 32

Hemolytic disease of the fetus and newborn (HDFN) is one of the serious causes of perinatal morbidity and mortality. It occurs because of a difference in red blood cell (RBC) antigens between the mother and fetus. The mother is alloimmunized during pregnancy or after blood transfusion. The mother’s antibodies, when of the IgG class, enter the placental circulation, bind to fetal antigens on the RBC surface, and cause hemolysis and/or anemia as a consequence of erythropoiesis suppression. The

J. Novoselac, M. Raos, G. Tomac, M. Lukić, B. Golubić Ćepulić

Immunohematology, Volume 36 , ISSUE 2, 54–57

case-report | 30-September-2021

A mild case of hemolytic disease of the fetus and newborn due to anti-Sc2

Hemolytic disease of the fetus and newborn (HDFN) occurs when the pregnant mother is alloimmunized with immunoglobulin (Ig)G-type antibodies specific for antigens present on the red blood cells (RBCs) of the fetus. These antibodies cross the placenta, and hemolysis occurs when the maternal antibody binds to the fetal RBC antigens, generating a binding to the Fc receptor of macrophages in the spleen of the fetus. After delivery, the continuous destruction of RBCs can cause progressive anemia and

M.A. Núñez Ahumada, C.E. Arancibia Aros, C.E. Villalobos Pavez, F.M. Pontigo Gonzalez, V. Abarca Arce, M. Sandoval Medrano, S. Reyes Jorquera

Immunohematology, Volume 37 , ISSUE 3, 122–125

Case report | 30-June-2016

Body stalk anomaly: antenatal sonographic diagnosis of this rare entity with review of literature

phenomenon. Sonographic features of the fetus included a severe midline defect of the fetal abdominal wall with a large extra-abdominal mass containing bowel and liver inside. Body stalk anomaly is accepted as a fatal anomaly, so it is important to differentiate it from other anterior wall defects for evaluating the management options.

Amandeep Singh, Jasmeet Singh, Kamlesh Gupta

Journal of Ultrasonography, Volume 17 , ISSUE 69, 133–135

Review | 16-October-2019

A brief overview of clinical significance of blood group antibodies

can occur via exposure to foreign (donor) RBC antigens through previous transfusions, transplants, or exposure to fetal RBCs during or after pregnancy. However, not all blood group antibodies are clinically significant. Clinically significant blood group antibodies can cause adverse events after blood component transfusion or transplantation and/or can cause hemolytic disease of the fetus and newborn.

Manish J. Gandhi, D. Michael Strong, Barbee I. Whitaker, Evangelia Petrisli

Immunohematology, Volume 34 , ISSUE 1, 4–6

Report | 01-December-2019

Comparison of estimation of volume of fetomaternal hemorrhage using KleihauerBetke test and microcolumn gel method in D-negative nonisoimmunized mothers

fetal cells were seen after examining 25 fields using 10× objective. If fetal cells were seen, slides were examined further to quantify FMH. By microcolumn gel method, FMH was reported as less than 0.1 percent, 0.1 percent, 0.2 percent, and 0.4 percent or greater. None of the patients had FMH greater than 15 mL by KB. Sixty-two patients (77.5%) had FMH less than 4 mL by KB. In all these cases, FMH was less than or equal to 0.2 percent (approximately 4 mL) by microcolumn gel method. The mean

Kshitija Mittal, Neelam Marwaha, Praveen Kumar, Subhash C. Saha, Beenu Thakral

Immunohematology, Volume 29 , ISSUE 3, 105–109

Case report | 01-December-2019

Posttransplant maternal anti-D: a case study and review

, the antibody screen was negative. After the patient was admitted for the nonviable pregnancy, the products of con-ception were found to be D+ by DNA testing for RHD. There were no documented transfusions or pregnancies during the interval in which anti-D appeared. The timing of the alloimmunization was unusual. In a subsequent pregnancy, fetal D typing was performed by molecular methods.

Lisa Senzel, Cecilia Avila, Tahmeena Ahmed, Harjeet Gill, Kim Hue-Roye, Christine Lomas-Francis, Marion E. Reid

Immunohematology, Volume 28 , ISSUE 2, 55–59

Review | 31-August-2018

The role of ultrasonography in methotrexate therapy for ectopic pregnancy

. Ultrasound also allows to monitor the outcome of methotrexate therapy. This study is a review of literature regarding the management of ectopic pregnancy with methotrexate. Such ultrasound findings as the size of the ectopic mass, presence of fetal heart rate and free fluid have been confirmed as effective eligibility criteria for therapy with methotrexate. In the future, possibly also endometrial stripe thickness and the vascularity of the ectopic mass may be considered predictive of successful

Piotr Czuczwar

Journal of Ultrasonography, Volume 18 , ISSUE 73, 158–161

Article | 09-November-2020

Absence of hemolysis after a kidney transplant in an E+ recipient from a donor with anti-E

fetal red blood cells of her one pregnancy (the recipient). The kidney had been immediately perfused with saline after removal from the donor. No acute or delayed hemolysis was observed clinically or in laboratory tests performed immediately after the transplant and at 7, 15, and 30 days after the transplant. Antibody screens were still negative at 6 months. In this case, anti-E was not present in the transplanted kidney in sufficient concentration to cause hemolysis of the recipient’s red

Marcia C. Zago-Novaretti, Carlos Roberto Jorge, Eduardo Jens, Pedro Enrique Dorihiac-Llacer, Dalton de Alencar Fischer Chamone

Immunohematology, Volume 13 , ISSUE 4, 138–140

Case report | 26-October-2019

Severe hemolytic disease of the fetus and newborn due to anti-C+G

immunohematology laboratory and the obstetric unit is essential. In previously affected families, early assessment for fetal anemia is required even when titers are low.

Riina Jernman, Vedran Stefanovic, Anu Korhonen, Katri Haimila, Inna Sareneva, Kati Sulin, Malla Kuosmanen, Susanna Sainio

Immunohematology, Volume 31 , ISSUE 3, 123–127

Research paper | 10-October-2018

Testosterone enhancement during pregnancy influences social coping and gene expression of oxytocin and vasopressin in the brain of adult rats

Steroid hormones are important mediators of prenatal maternal effects and play an important role in fetal programming. The aim of our study was to investigate how testosterone enhancement during pregnancy influences neurobehavioral aspects of social coping of rat offspring in adulthood. Pregnant rat dams were exposed to depot form of testosterone during the last third of pregnancy (i.e., beginning on the 14th day of pregnancy). Their adult offspring were later tested in a social interaction

Zuzana Dzirbíková, Alžbeta Talarovičová, Peter Štefánik, Lucia Olexová, Lucia Kršková

Acta Neurobiologiae Experimentalis, Volume 78 , ISSUE 3, 264–270

Case report | 12-March-2020

Role for serial prenatal anti-Vel quantitative serologic monitoring with 2-ME serum treatment during pregnancy: case report

trimester (week 7) of her second pregnancy. Interval measurements of the serologic antibody titers were performed during the next 26 weeks. The untreated serum (IgM and IgG) titer increased from a baseline of 4 to 16 during that interval, while the 2-ME (presumed IgG component) titer remained stable at 4. Responding to ultrasound findings suspicious for fetal anemia, the child was delivered without complications at 34 weeks’ gestation. At birth, the DAT was negative and there was no evidence of

Walter J. Linz, Judith T. Fueger, Steven Allen, Susan T. Johnson

Immunohematology, Volume 26 , ISSUE 1, 8–10

Article | 18-October-2020

A successful delivery of a baby from a D––/ D–– mother with strong anti-Hr0

, fetal cells were direct antiglobulin test positive and the blood type was group O, D+ (CDe). We performed plasma exchanges in the mother; however, the titer of antibody rebounded to its initial level after the third plasma exchange. At 26 weeks gestation, cord blood Hb decreased to 7.1 g/dL and three intrauterine transfusions were performed using the mother’s washed red blood cells (RBCs). At 34 weeks gestation, a live baby was delivered by cesarean section. The infant was hydropic with

Dong Hee Whang, Hee Chung Kim, Mina Hur, Jung Hwan Choi, Joong Shin Park, Kyou Sup Han

Immunohematology, Volume 16 , ISSUE 3, 112–114

Case report | 09-November-2020

Quantitating fetomaternal hemorrhages of D+ red cells using an FITC-conjugated IgG monoclonal anti-D by flow cytometry: a case report

patient who presented with a large fetal bleed (approx. 80mL) as determined using the Kleihauer method. We compared the efficacy of the direct FC technique to the rosetting and Kleihauer tests in estimating the quantity of Rh immunoglobulin (RhIg) to be administered to the mother to suppress Rh alloimmunization. Both the Kleihauer and the direct FC gave precise estimates of 80mL for the size of bleed, whereas the rosetting test failed to be as precise. The former tests predicted that a 10,000 iu dose

Anatole Lubenko, John Raymond Collier, Mark Williams, Damien Hindmarch, Sally Rosemary Wilson, Julie Pluck

Immunohematology, Volume 13 , ISSUE 1, 12–14

research-article | 09-September-2021

MV-Flow and LumiFlow: a new Doppler tool for assessing the development of fetal brain vascularization in late-first/early-second trimester of pregnancy

Early prenatal assessment of the development of cerebral vascularization represents a real challenge in the field of fetal medicine. A detailed identification of those vessels and their formation carries great importance, especially in the late-first/early-second trimester of pregnancy, because an early identification of defects can be largely beneficial for treatment planning. By using transvaginal ultrasonography in the second and third trimesters, Monteagudo et al. described the detailed

Alessandro Giuffrida, Eduardo Félix Martins Santana, Edward Araujo

Journal of Ultrasonography, Volume 21 , ISSUE 86, 258–259

Research Article | 22-May-2019


Bovine viral diarrhea virus (BVDV) is classified as a member of the Pestivirus genus of the Flaviviridae family. BVDV is one of the most important viral pathogens of ruminants worldwide, causing severe economic losses. Infection results in a wide range of clinical manifestations, ranging from mild respiratory disease to fetal death and mucosal disease. The virus particles are small and contain a single-stranded, positive-sense RNA molecule of approximately 12.3 kb with one large open reading

Paweł Mirosław, Aleksandra Antos, Mirosław Polak

Postępy Mikrobiologii - Advancements of Microbiology, Volume 56 , ISSUE 4, 389–394

Article | 10-November-2020

Do monocyte ADCC assays accurately predict the severity of hemolytic disease of the newborn caused by antibodies to high-frequency antigens?

related to fetal antigen expression and tissue distribution. The anti-Inb was further investigated using mono­cyte binding and inhibition studies. The absence of HDN in the pres­ence of potent anti-U remains unexplained. In general, antibodies with low ADCC activity do not cause HDN, but high ADCC activity does not always indicate severe HDN.

Stephen F. Garner, Alan Devenish

Immunohematology, Volume 12 , ISSUE 1, 20–26

Review | 30-June-2017

Can ultrasound be helpful in selecting optimal management methods for pregnancies complicated by placental non-trophpblastic tumors?

Placental chorioangioma is the most common subtype of non-trophoblastic placental tumors. Other subtypes are very rare and usually associated with an uneventful course of pregnancy. Most chorioangiomas are small and of no clinical significance. Giant chorioangiomas may be associated with serious fetal and maternal complications. So far, no established ultrasound guidelines are available for the management of placental non-trophoblastic tumors. This may be attributed to the rarity of the disease

Nabil Abdalla, Robert Piórkowski, Paweł Stanirowski, Monika Pazura, Krzysztof Cendrowski, Włodzimierz Sawicki

Journal of Ultrasonography, Volume 17 , ISSUE 69, 116–122

original-paper | 28-June-2019

Fertility outcome after saline sonography guided removal of intrauterine polyps in women with unexplained infertility

transvaginal scan was done to confirm a fetal heart beat. Follow up All women with polyps, whether they requested removal or not, were followed for a period of twelve months. The follow up was maintained via telephone calls and repeated transvaginal scans at 3, 6, 9 and 12 months. Those who did not comply with the follow up, were not included in the final statistical analysis. Those with recurrence of polyps were planned to have removal and follow up adjusted. The primary outcome measure was women who

Rubina Izhar, Samia Husain, Suhaima Tahir, Sonia Husain

Journal of Ultrasonography, Volume 19 , ISSUE 77, 113–119

Research Article | 30-March-2018

Utility of Doppler parameters at 36–42 weeks’ gestation in the prediction of adverse perinatal outcomes in appropriate-for-gestational-age fetuses

AimTo investigate the potential value of Doppler ultrasound and to assess cerebroplacental ratio (CPR) in the prediction of adverse perinatal outcome defined as Apgar score < 7 at 1 minute.Material and methodsThis was a retrospective cross-sectional study in selected pregnant women undergoing an ultrasound examination between 36 and 42 weeks of gestation. We measured estimated fetal weight (EFW), mean umbilical artery pulsatility index (UA PI), mean middle cerebral artery pulsatility index

Michał Migda, Katarzyna Gieryn, Bartosz Migda, Marian Stanisław Migda, Marek Maleńczyk

Journal of Ultrasonography, Volume 18 , ISSUE 72, 22–28

Pictorial Review | 25-September-2018

Acrania-exencephaly-anencephaly sequence phenotypic characterization using two- and three-dimensional ultrasound between 11 and 13 weeks and 6 days of gestation

systematic fetal head and brain examination including the formation of cranial bones, choroid-plexus and ventricles. Acrania-exencephaly-anencephaly sequence and/or other neural tube defects, such as meningoencephalocele, may be identified during a routine 11–14 week scan. Early first trimester detection of acrania-exencephaly-anencephaly sequence with the characterization of different related phenotypes, 2D and 3D ultrasound imaging as well as differential diagnosis are also presented in this pictorial

Eduardo Félix Martins Santana, Edward Araujo Júnior, Gabriele Tonni, Fabricio Da Silva Costa, Simon Meagher

Journal of Ultrasonography, Volume 18 , ISSUE 74, 240–246

research-article | 15-June-2020

Cervical stenosis and pregnancy rate after ultrasound guided cervical dilation in women undergoing saline infusion sonography

they became pregnant. Transvaginal scan was done to confirm fetal heart beat. All women were followed for a period of twelve months. The follow up was maintained via telephone calls and repeat transvaginal scans at 3, 6, 9 and 12 months. Those who did not comply with the follow up were not included in the final statistical analysis. The primary outcome measure was women who had clinical pregnancy i.e. fetal heartbeat present on transvaginal scan after they were serum beta hCG positive during the

Journal of Ultrasonography, Volume 20 , ISSUE 81, e116–e121

Article | 14-October-2020

Neonatal alloimmune thrombocytopenia due to anti-HPA-2b (anti-Koa)

Most severe cases of neonatal alloimmune thrombocytopenia (NAIT) are due to anti-HPA-1a (anti-PlA1) antibodies. We report a case of NAIT due to anti-HPA-2b that resulted in in utero intracranial hemorrhage.A 33-year-old G2P1A0 Caucasian woman had a routine ultrasound at 34 weeks. The fetus appeared to have a left hemispheric hematoma. IVIG, 1g/kg, was started immediately and administered weekly until delivery. One day after receiving the first dose of IVIG, fetal platelet count was 18 ×

Mindy Goldman, Élise Trudel, Samir Khalife, Gwendoline M. Spurll

Immunohematology, Volume 19 , ISSUE 2, 43–46

Report | 26-October-2019

First example of an FY*01 allele associated with weakened expression of Fya on red blood cells

. Phenotypematched units were desired for a multi-transfused Vietnamese fetus with α-thalassemia. Genotyping of the fetus using a microarray assay that interrogates three SNPs (c.1-67, c.125, and c.265) in FY yielded indeterminate results for the predicted Duffy phenotype. Genomic sequencing of FY exon 2 showed that the fetal sample had one wild-type FY*01 allele and one new FY*01 allele with the c.265C>T SNP, which until recently had only been found on the FY*02 allele. Genotyping performed on samples

Patricia A. Arndt, Trina Horn, Jessica A Keller, Rochelle Young, Suzanne M. Heri, Margaret A. Keller

Immunohematology, Volume 31 , ISSUE 3, 103–107

Review | 31-August-2018

Ultrasound screening for pyelectasis in pregnant women. Clinical necessity or “art for art’s sake”?

pregnant woman and to prematurity, anemia, congenital pneumonia or sepsis in the child. In a study conducted at the 3rd Department of Gynecology of the Medical University of Lublin it was concluded that unilateral pyelectasis of more than 20 cm3 is associated with a significant increase in the risk of asymptomatic bacteriuria. This volume corresponds to grade 3 and/or 4 pelvicalyceal dilatation according to the Society for Fetal Urology/European Federation of Societies for Ultrasound in Medicine and

Piotr Szkodziak

Journal of Ultrasonography, Volume 18 , ISSUE 73, 152–157

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