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Research paper | 14-August-2017

Effectors of large-conductance calcium-activated potassium channel modulate glutamate excitotoxicity
in organotypic hippocampal slice cultures

neuroprotective effects of BKCa channel modulators. Using organotypic hippocampal slice cultures exposed to glutamate, we demonstrated that preincubation of the slices with the BKCa channel opener NS1619 resulted in decreased neuronal cell death measured as reduced uptake of propidium iodide. This neuroprotective effect was reversed by preincubation with the BKCa channel inhibitors paxilline and Iberiotoxin (IbTx). Moreover, mitochondrial respiration measurements revealed that NS1619 induced an

Marta Piwońska, Adam Szewczyk, Ulrich H. Schröder, Klaus G. Reymann, Piotr Bednarczyk

Acta Neurobiologiae Experimentalis, Volume 76 , ISSUE 1, 20–31

research-article | 06-April-2020

Hindbrain metabolic deficiency regulates ventromedial hypothalamic nucleus glycogen metabolism and glucose-regulatory signaling

hypoglycemia, DVC lactate deficiency activates A2 neurons (Patil and Briski, 2005) and increases hypothalamic NE activity (Shrestha et al., 2014). Hypoglycemic patterns of NE input to the MBH regulate GABA release (Beverly et al., 2000; 2001). Our recent studies affirm a positive causal relationship between NE and VMN GABA as site-targeted delivery of exogenous NE up-regulates the GABA marker protein glutamate decarboxylase65/67 (GAD65/67) (Ibrahim et al., 2019). Current research investigated the

Karen P. Briski, Santosh K. Mandal

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 1, 57–65

Research paper | 31-July-2017

Age‑dependent concomitant changes in synaptic function and GABAergic pathway in the APP/PS1 mouse model

suggested to be as a result of the interplay between inhibitory and excitatory neuronal mechanism. The present study therefore investigates functional deficiency in the inhibitory system as complementary to the identified alterations in the glutamate excitatory pathway in AD. Since synaptic function deficit in AD is typically linked to progression/pathology of the disease, it is important to determine whether the deficits in the GABAergic system are functional and can be directly linked to the pattern

Tutu Oyelami, An De Bondt, Ilse Van den Wyngaert, Kirsten Van Hoorde, Luc Hoskens, Hamdy Shaban, John A. Kemp, Wilhelmus H. Drinkenburg

Acta Neurobiologiae Experimentalis, Volume 76 , ISSUE 4, 282–293

Review | 10-October-2018

The role of DSCAM in the regulation of synaptic plasticity: possible involvement in neuropsychiatric disorders

synaptic plasticity. The review will present information on DSCAM and how it is connected to glutamate (Glu) and γ-Aminobutyric acid (GABA) neurotransmission pathways. Finally, the review throws some light on the possible involvement of DSCAM in a spectrum of psychiatric disorders apart from Down syndrome (DS).

Katarzyna Stachowicz

Acta Neurobiologiae Experimentalis, Volume 78 , ISSUE 3, 210–219

research-article | 30-November-2020

Deep brain stimulation effects on learning, memory and glutamate and GABAA receptor subunit gene expression in kindled rats

in the suppression of seizure activity. Significant changes in the expression of GABAA receptor (GABAAR) subunits have been reported in the hippocampus of epileptic patients (Baulac et al., 2001) and kindled animals (Sperk et al., 2004). Additionally, the GABAergic system involves in memory processing (Givens and Olton, 1990; Chrobak and Napier, 1992) and blocking GABAARs leads to spatial and working memory impairments (Rao et al., 2000). In addition to glutamate and GABA receptors, protein

Mona Faraz, Nastaran Kosarmadar, Mahmoud Rezaei, Meysam Zare, Mohammad Javan, Victoria Barkley, Amir Shojaei, Javad Mirnajafi-Zadeh

Acta Neurobiologiae Experimentalis, Volume 81 , ISSUE 1, 43–57

Review Paper | 26-March-2014

Selected classical and novel antiepileptic drugs – mechanisms of action, neuroprotection, and effectiveness in epileptic and non-epileptic conditions

drugs (AEDs – lamotrigine, topiramate, levetiracetam, valproate and carbamazepine). Methods. A literature search for publications written in English, preferably published within a period of the last fifteen years, using the key words listed below. Review. The majority of AEDs possess more than one mechanism of action. They exert their effect by acting on various receptors (different types of glutamatergic and mainly GABAA receptors), neurotransmitters (mainly glutamate or GABA) and voltage

Magdalena Chrościńska-Krawczyk, Magdalena Wałek, Bożydar Tylus, Stanisław J. Czuczwar

Journal of Epileptology, Volume 22 , ISSUE 1, 37–50

original-paper | 08-September-2020

Characteristics of the Jejunal Microbiota in 35-Day-Old Saba and Landrace Piglets

jejunal microbiota’s metabolic potential, we performed Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt) (Langille et al. 2013; Javurek et al. 2016). KEGG pathway (L3 hierarchy) analysis is shown in Fig. 7. The “d-glutamine and d-glutamate metabolism”, and “one carbon pool by folate” pathway were enriched in Saba piglets. The “limonene and pinene degradation”, “tryptophan metabolism”, and “sulfur relay system” were enriched in Landrace piglets. Fig. 7. KEGG

HUAN GAO, YUTING YANG, ZHENHUI CAO, JINMING RAN, CHUNYONG ZHANG, YING HUANG, MINGHUA YANG, SUMEI ZHAO, QINGCONG AN, HONGBIN PAN

Polish Journal of Microbiology, Volume 69 , ISSUE 3, 367–378

Review Paper | 30-November-2015

The role of cannabinoids and endocannabinoid system in the treatment of epilepsy

many biochemical and physiological processes. By affecting glutamate and gamma-aminobutyric acid (GABA) neurotransmission cannabinoids have the ability to affect seizure threshold. The best known cannabinoid is cannabidiol, which inhibits the occurrence of seizures without causing significant side effects in humans and animals. However, only a small number of double blind, randomized and placebo controlled studies have been published to date. Conclusions. The role of cannabinoids in the treatment

Monika Pędracka, Jacek Gawłowicz

Journal of Epileptology, Volume 23 , ISSUE 2, 131–138

Original Paper | 24-June-2016

Russian experience of using perampanel in daily clinical practice. Preliminary report

Introduction. Perampanel (PER) (Fycompa) 5'-(2-cyanophenyl)-1'-phenyl-2,3'-bipyridinyl-6'(1'H)-on is the newest antiepileptic drug and is the first-in-class selective non-competitive antagonist of ionotropic AMPA glutamate receptors of the postsynaptic neuronal membrane. The aim was to summarize Russian experience in using PER in daily clinical practice, and for this purpose the results of its use as an add-on treatment for focal epilepsy were assessed retrospectively

Pavel Vlasov, Vladimir Karlov, Irina Zhidkova, Aleksandr Chervyakov, Oleg Belyaev, Iosif Volkov, Diana Dmitrenko, Antonina Karas, Tatiana Kazennykh, Olga Miguskina, Anna Moskvicheva, Elena Paramonova, Irina Ponomareva

Journal of Epileptology, Volume 24 , ISSUE 1, 7–14

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