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review-article | 30-November-2020

Neurobiological effects of forced swim exercise on the rodent hippocampus: a systematic review

fatigue avoided are points desired in most methods. For that many protocols were developed and adapted, perfecting these aspects, and promoting neurobiological effects in rodents. When studying the consequences of this physical exercise, one of the brain structures most researched is the hippocampus. In rodents the hippocampus is an elongated C-shaped structure with a bilateral formation between the cerebral cortex and the thalamus (Amaral and Witter, 1989). It has a long or septotemporal axis that

Rodrigo Freire Oliveira, Karina Maia Paiva, Gabriel Sousa da Rocha, Marco Aurélio de Moura Freire, Dayane Pessoa de Araújo, Lucídio Cleberson de Oliveira, Fausto Pierdoná Guzen, Paulo Leonardo Araújo de Gois Morais, José Rodolfo Lopes de Paiva Cavalcanti

Acta Neurobiologiae Experimentalis, Volume 81 , ISSUE 1, 58–68

research-article | 30-November-2019

Serotonin and noradrenaline content and release in the dorsal hippocampus during learning and spatial memory in prenatally stressed rats

INTRODUCTION In rodents, maternal stress during pregnancy can cause psychopathologies in the offspring, such as anxiety and depressive-like behaviors, as well as cognitive deficits (Weinstock, 2017). Also, alterations in development and maturation of brain structures, such as the hippocampus, have been reported (Fujioka et al., 2006). The dorsal hippocampus is involved in spatial learning and memory processes in rats and primates (Bannerman et al., 2004; Tanti and Belzung, 2013; Grigoryan and

Diana Méndez Guerrero, Felipe de Jesús Jiménez Vásquez, Moisés Rubio Osornio, María del Carmen Rubio Osornio, Sandra Orozco Suárez, Socorro Retana-Márquez

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 4, 400–410

research-article | 30-November-2019

Decreased serotonin content and release in the ventral hippocampus of prenatally stressed male rats in response to forced swim test

prenatally stressed offspring in animal models is the low capacity to coping with stress due to the de-regulation of the HPA axis, thus increasing susceptibility to adult disorders, such as hyperactivity and hyperreactivity of HPA axis (Fan et al., 2009), metabolic diseases (Tamashiro et al., 2009), cognitive deficits (Guerrero et al., 2016), anxiety-like behavior (Brunton and Russel, 2010) or depressive-like behavior (Brunton, 2013). The ventral hippocampus is related to the stress response (Herman et

Felipe de Jesús Jiménez Vásquez, Diana Méndez Guerrero, Moisés Rubio Osornio, María del Carmen Rubio Osornio, Sandra Orozco Suárez, Socorro Retana-Márquez

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 4, 331–343

research-paper | 12-August-2019

Modulation of catalase, copper and zinc in the hippocampus and the prefrontal cortex in social isolation-induced depression in male rats

depression in socially isolated people is not fully understood. In this study, we hypothesized that fourteen days of social isolation would lead to a reduction in zinc and copper levels and catalase activity in the hippocampus and prefrontal cortex that may contribute to the occurrence of depression. The prefrontal cortex is a brain region often investigated in psychiatric illnesses (Vostrikov et al., 2007). The hippocampus is also of particular importance for studying depressive and anxiety behavior

Hamidreza Famitafreshi, Morteza Karimian

Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 2, 184–192

research-paper | 12-August-2019

The effect of bupropion augmentation of minocycline in the treatment of depression

analysis in the brain was carried out in 3 areas i.e. the hippocampus, cerebral cortex, and the whole brain (whole brain=hippocampus + cerebral cortex + remaining brain tissue). It was conducted using the HPLC (Shimadzu, LC-2010C HT) with FD (RF-20A-prominence, Shimadzu) method (Lakshmana and Raju, 1997; Choudhary et al., 2013; Kale et al., 2014). Approximately 1 h before euthanasia, mice were treated. After performing the TST at a 30 min interval, mice heads were dropped in 0.1 M perchloric acid at

Monica Bendale, Sharon Ronald D'souza, Veeranjaneyulu Addepalli, Pravin Popatrao Kale

Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 2, 217–224

research-article | 06-April-2020

Moderate exercise prevents the cell atrophy caused by hypothyroidism in rats

hippocampus in both rats (Alva-Sánchez et al., 2009a) and humans (Cooke et al., 2014). Hypothyroid rats show reductions in the total weight of the hippocampus and in the volume on the Ammon’s horn (Madeira et al., 1992), which is consistent with an increase in the proportion of atrophic neurons in this region (Alva-Sánchez et al., 2009b; Khordad et al., 2018) and a reduction of the number of pyramidal cells particularly in CA1 (Madeira et al., 1992). Along with this, dendritic arborization and dendritic

Carmen Martínez-Salazar, Iván Villanueva, Jorge Pacheco-Rosado, Claudia Alva-Sánchez

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 1, 47–56

Short Communication | 10-October-2018

MMP-3 deficiency does not influence the length and number of CA1 dendrites of hippocampus of adult mice

Daria Nowak, Lies De Groef, Lieve Moons, Jerzy W. Mozrzymas

Acta Neurobiologiae Experimentalis, Volume 78 , ISSUE 3, 281–286

Research paper | 22-August-2018

Administration of muscarinic antagonists induce changes in passive avoidance learning and in synaptic transmission in the CA1 area of the hippocampus

Yulia V. Dobryakova, Olga Y. Ivanova, Vladimir A. Markevich

Acta Neurobiologiae Experimentalis, Volume 78 , ISSUE 2, 132–139

research-article | 30-November-2019

Lovastatin alters neurotrophin expression in rat hippocampus-derived neural stem cells in vitro

concentration to induce such effects. METHODS Isolation and expansion of NSCs NSCs were isolated from the hippocampus of three neonatal Wistar rats (5–10 days old) purchased from the Razi Vaccine and Serum Research Institute (Karaj, Iran). Briefly, under deep anesthesia by intraperitoneal injection of ketamine/xylazine (100 mg/kg and 10 mg/kg, respectively), the brains were removed and the dissected hippocampi washed in the ice-cold phosphate-buffered saline (PBS, Gibco), supplemented with 4.5 g/L

Farzaneh Fakheri, Alireza Abdanipour, Kazem Parivar, Iraj Jafari Anarkooli, Hossein Rastegar

Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 4, 413–420

Research paper | 06-February-2018

Comparison of the influence of two models of mild stress on hippocampal brain-derived neurotrophin factor (BDNF) immunoreactivity in old age rats

pyramidal neurons, which was probably connected with up-regulation of HPA axis activity and short-time memory processing of the stressful situation. Moreover, as far as the influence on BDNF-ir cells in hippocampus is concerned, chronic FS or HL-OF was not an aggravating factor for rats in the ontogenetic periods studied.

Ewa Badowska-Szalewska, Beata Ludkiewicz, Rafał Krawczyk, Natalia Melka, Janusz Moryś

Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 1, 68–76

research-paper | 12-August-2019

Prenatal ethanol intoxication and maternal intubation stress alter cell survival and apoptosis in the postnatal development of rat hippocampus

, hippocampus and cerebellum are especially sensitive to ethanol exposure (Tran and Kelly, 2003). The ethanol-associated neuronal damage which is initiated by activation of the mitochondrial apoptotic pathway (Cartwright et al., 1998; Ikonomidou et al., 2000; Light et al., 2002; Ramachandran et al., 2003; Dikranian et al., 2005) may be related to several molecular mechanisms including induction of oxidative stress, activation of caspase-3, functional loss of neurotrophic factors and inhibition of survival

Birsen Elibol, Merve Beker, Cigdem Dilek Sahbaz, Ulkan Kilic, Ewa Jakubowska-Doğru

Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 2, 133–147

Research paper | 06-February-2018

Effects of individual stressors used in a battery of “chronic unpredictable stress” on long-term plasticity in the hippocampus of juvenile rats

Alexandra A. Gorbunova, Irina V. Kudryashova, Anna O. Manolova, Margarita R. Novikova, Mikhail Yu. Stepanichev, Natalia V. Gulyaeva

Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 3, 244–253

research-article | 07-July-2020

Intracerebroventricular streptozotocin induces behavioral impairments and increases short-term C3 gene expression in the hippocampus of Wistar rats

-STZ (Shoham et al., 2003). Additionally, 3 h after STZ injections, disruption of working memory has been observed followed by degenerative processes in the hippocampus at 1 and 15 days after STZ injections. Furthermore, memory disruptions increase over time (Santos et al., 2012) as demonstrated by mice that received icv-STZ and showed impairment in learning and spatial memory 21 days after STZ administration (Chen et al., 2012). Bao and coworkers (2017) also found that icv-STZ remarkably induced

Gabrielle Pfutzenreuter, Kenny Nieradka, Márcia Regina Pincerati, Ilton Santos da Silva

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 2, 160–169

Research paper | 25-July-2017

Aberrant changes of somatostatin and neuropeptide Y in brain of a genetic rat model for epilepsy: tremor rat

(TRM)is a genetic epileptic animal model which can manifest tonic convulsions without any external stimuli. The present study aimed to investigate the distribution and expression of SST and NPY in TRM brains, including hippocampus, temporal lobe cortex and cerebellum.Our RT‑PCR data showed that up‑regulated mRNA expression of SST and NPY was discovered in TRM hippocampus and temporal lobe cortex compared with control (Wistar) rats. The peptide levels of these neuropeptides in brain areas mentioned

Xiaoxue Xu, Feng Guo, Xinze Cai, Jun Yang, Jiuhan Zhao, Dongyu Min, Qianhui Wang, Liying Hao, Jiqun Cai

Acta Neurobiologiae Experimentalis, Volume 76 , ISSUE 3, 165–175

research-article | 30-November-2020

Regular aerobic exercise increased VEGF levels in both soleus and gastrocnemius muscles correlated with hippocampal learning and VEGF levels

hippocampus, which is the primary center of learning and memory (Radák et al., 2001; Fabel et al., 2003; Winter et al., 2007; Cassilhas et al., 2012; Khabour et al., 2013; Ballard, 2017; Jeong et al., 2018). In previous studies, we have demonstrated the memory enhancing effects of exercise accompanied by increased neuronal density in the hippocampus (Uysal et al., 2005, 2017; Cetinkaya et al., 2013). Skeletal muscle is an exercise-responsive tissue that produces hormones and signaling factors in order to

Asli Karakilic, Oguz Yuksel, Servet Kizildag, Ferda Hosgorler, Birsu Topcugil, Rabia Ilgin, Hikmet Gumus, Guven Guvendi, Basar Koc, Sevim Kandis, Mehmet Ates, Nazan Uysal

Acta Neurobiologiae Experimentalis, Volume 81 , ISSUE 1, 1–9

Research paper | 18-May-2018

Possible role of hippocampal GPR55 in spatial learning and memory in rats

Endocannabinoids (eCBs) are involved in the hippocampal mechanisms of spatial learning and memory in rats. Although eCBs exert many of their actions on spatial learning and memory via CB1 receptors, the putative cannabinoid receptor GPR55 (expressed in the hippocampus, cortex, forebrain, cerebellum and striatum) seems to be also involved. To investigate the potential role of GPR55 in spatial learning and memory, Wistar rats received bilateral infusions of lysophosphatidylinositol (LPI, GPR55

Bruno A. Marichal-Cancino, Alfonso Fajardo-Valdez, Alejandra E. Ruiz-Contreras, Mónica Méndez-Díaz, Oscar Prospéro-García

Acta Neurobiologiae Experimentalis, Volume 78 , ISSUE 1, 41–50

research-article | 30-November-2019

Diverse changes in myelin protein expression in rat brain after perinatal methadone exposure

-5% CO2. Four regions (cortex, hippocampus, cerebellum, and brain stem) were dissected out on ice for protein preparation. Western blots Protein samples were prepared in CelLytic™ MT Cell Lysis Reagent (Sigma-Aldrich, St. Louis, MO) containing the complete protease inhibitors (Roche, Indianapolis, IN) on ice. Western blots were performed as described previously (Cai et al., 2012; Wang et al., 2018). Equivalent amounts of total protein (30 μg/lane) were separated using 10% SDS-polyacrylamide

Rahul Oberoi, Tianci Chu, Nicholas Mellen, Rekha Jagadapillai, Hezhong Ouyang, Lori A. Devlin, Jun Cai

Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 4, 367–373

research-article | 30-November-2019

Crocin acts as a neuroprotective mediator against methylphenidate-induced neurobehavioral and neurochemical sequelae: Possible role of the CREB-BDNF signaling pathway

treatment; indeed, previous studies have demonstrated that chronic MPH-induced locomotion and repetitive movements were due to a decrease in GABA transmission, whereas the GABAergic system was not significantly altered following acute MPH treatment (Freese et al., 2012; Goitia et al., 2013). Experimental studies have confirmed the potential effects of MPH on neurodegeneration of several brain areas including the hippocampus, which is involved in cognition and anxiety (Andreazza et al., 2007; Jones and

Andia Ebrahimzadeh, Sara Yousefi Moghadam, Hanieh Rahimi, Majid Motaghinejad, Manijeh Motevalian, Sepideh Safari, Mobina Abbasi Mesrabadi

Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 4, 352–366

research-article | 30-November-2020

Experimental chronic sleep fragmentation alters seizure susceptibility and brain levels of interleukins 1β and 6

experimental model of lindane-induced seizures and a high frequency sleep disruption model of sleep fragmentation characteristic for obstructive sleep apnea. We also wanted to examine the effect of sleep fragmentation on the IL-1beta and IL-6 levels in the hippocampus, thalamus and cortex of rat’s brain tissue, and see if they could bridge the missing link between these disorders. METHODS Animals and housing Two months old male Wistar albino rats were used. The animals were obtained from the Military

Željko Grubač, Nikola Šutulović, Djudja Jerotić, Sonja Šuvakov, Aleksandra Rašić-Marković, Djuro Macut, Tatjana Simić, Olivera Stanojlović, Dragan Hrnčić

Acta Neurobiologiae Experimentalis, Volume 81 , ISSUE 1, 96–109

research-article | 30-November-2018

Stimulus-seeking in rats is accompanied by increased c-Fos expression in hippocampal CA1 as well as short 22 kHz and flat 50 kHz calls

calls within the 50 kHz range. However, the nose-pokes performed during the last (i.e., test) session that were accompanied with flat 50 kHz calls correlated positively with the number of c-Fos-positive nuclei in the CA1 region of the hippocampus (r=0.50, p<0.05). This correlation was stronger in the experimental group (r=0.84, p<0.05) and was not observed in the control rats. Finally, since short 22 kHz USV and flat 50 kHz calls seemed to follow a similar pattern and were both associated with the

Ita Robakiewicz, Monika Polak, Małgorzata Rawska, Dominik Alberski, Rafał Polowy, Kinga Wytrychiewicz, Mateusz Syperek, Jan Matysiak, Robert K. Filipkowski

Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 3, 310–318

Research paper | 04-May-2018

Effects of different delayed exercise regimens on cognitive performance in fimbria-fornix transected rats

Elise Wogensen, Linda Marschner, Marie Gajhede Gram, Siri Mehlsen, Valdemar H. B. Uhre, Pernille Bülow, Jesper Mogensen, Hana Malá

Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 4, 323–336

research-article | 08-July-2020

The inhibitory effects of bile acids on catalytic and non-catalytic functions of acetylcholinesterase as a therapeutic target in Alzheimer’s disease

pathophysiological and behavioral signs of the disease (Toledano and Alvarez, 2004; Gratwicke et al., 2013). Previous results demonstrated that impaired memory related to AD is dependent on hippocampal function (Moodley et al., 2015; Sadeghi et al., 2018). Therefore, we investigated CD and/or SDC for beneficial effects on the NBML rats’ hippocampus through biochemical analysis, immunological evaluation and histological studies. METHODS Animals In vivo study was conducted on experimental animals by using 4.5-6

Leila Sadeghi, Reza Yekta, Gholamreza Dehghan

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 2, 108–116

Research paper | 01-August-2017

The effects of edaravone in ketamine-induced model of mania in rats

order to evaluate oxidative damage in the rat hippocampus and prefrontal cortex. Increased locomotor activity (hyperlocomotion) was observed at the open-field test with ketamine treatment (25 mg/kg, i.p., 8 days). Edaravone (18 mg/kg) treatment did not prevent hyperlocomotion in the mania model induced with ketamine in rats, but lithium chloride (47.5 mg/kg, i.p., positive control) did prevent hyperlocomotion. Edaravone and lithium chloride treatments were found to reduce the increase in SOD and CAT

Filiz Civil Arslan, Ahmet Tiryaki, Mehmet Yıldırım, Evrim Özkorumak, Ahmet Alver, İlkay Keleş Altun, İmran İnce, Öznur Gedikli

Acta Neurobiologiae Experimentalis, Volume 76 , ISSUE 3, 192–198

Research paper | 18-May-2018

Long-term behavioral, histological, biochemical and hematological evaluations of amyloid beta-induced Alzheimer’s disease in rat

(surgery without injection Aβ), and experimental group (two-sided intrahippocampal amyloid-beta injection into hippocampus). From each group, three animals were investigated 42 days after injection, and the remaining four animals were studied after one year. All animals were tested for learning abilities and memory. Finally, samples from blood, brain, heart, kidney, liver, colon and spleen were examined. In the experimental group, the size of amyloid plaques were increased significantly after one year

Raheleh Kheirbakhsh, Mahnaz Haddadi, Ahad Muhammadnejad, Alireza Abdollahi, Farshad Shahi, Behzad Amanpour-Gharaei, Azadeh Abrahim-Habibi, Tahereh Barati, Saeid Amanpour

Acta Neurobiologiae Experimentalis, Volume 78 , ISSUE 1, 51–59

Research paper | 22-August-2018

Changes in neurogenesis with post-hatching age in the male Japanese quail (Cortunix japonica) brain

were also observed in the hippocampus and bed nucleus of stria terminalis. The density of PCNA-ir cells and DCX-ir cells in all brain areas declined with post-hatching age. In conclusion, cell proliferation appears to be restricted to the ventricular zones whereas neuronal recruitment is more widespread in the olfactory bulb, telencephalon and cerebellum. Postnatal neuronal incorporation appears to be absent in the diencephalon and mesencephalon.

Pilani Nkomozepi, Pedzisai Mazengenya, Amadi O. Ihunwo

Acta Neurobiologiae Experimentalis, Volume 78 , ISSUE 2, 173–186

Research paper | 04-May-2018

Antimuscarinic-induced convulsions in fasted mice after food intake: no evidence of spontaneous seizures, behavioral changes or neuronal damage

Prolonged or repeated seizures have been shown to cause spontaneous recurrent seizures, increased anxiety-related behavior, locomotor hyperactivity, impaired functions of learning and memory, and neuronal damage in the hippocampus and other brain regions in animals. Mice and rats treated with antimuscarinic drugs after fasting for two days or less develop convulsions after being allowed to eat ad libitum. To address whether such behavioral and neuroanatomic changes occur following these

Nurhan Enginar, Asiye Nurten, Aslı Zengin Türkmen, Gül İpek Gündoğan, Zeynep Güneş Özünal

Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 4, 373–381

research-article | 30-November-2018

Cell-based immunofluorescence assay for screening the neurogenesis potential of new drugs in adult hippocampal neural progenitor cells

Substantial neurogenesis and continuous supplementation of newborn neurons in the hippocampus and striatum of human adults indicate that neurogenesis may have important implications for brain function (Bergmann et al., 2015; Boldrini et al., 2018). Adult neurogenesis in the hippocampus is important for memory coding and mood regulation. Furthermore, alterations in adult neurogenesis are associated with several brain diseases, such as neurodegenerative diseases, ischemic stroke, and psychiatric

Kun Zhang, Bin Li, Peifang Li, Xiaoli Yang, Huixian Cui, Xiaoyun Liu

Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 3, 303–309

Review Paper | 10-December-2015

Antiepileptic drugs as a new therapeutic concept for the prevention of cognitive impairment and Alzheimer’s disease. Recent advances

, seems to be an rationale choice for MCI and AD treatment. Aim. To provide data from experimental and clinical studies on: 1. The unfavorable impact of neuronal hyperexcitability, mainly within the hippocampus, on cognitive processes. 2. Efficacy of AEDs against such abnormally elevated neuronal activity for the prevention of progressive cognitive impairment. Methods. A literature review of publications published within the last fifteen years, was conducted using the PubMed database. Review. The

Krzysztof Sendrowski, Wojciech Sobaniec

Journal of Epileptology, Volume 23 , ISSUE 2, 139–147

research-article | 30-November-2018

Alteration of oxidative stress markers and behavior of rats in a novel model of depression

groups that were housed individually. Bars presented as mean ± SEM. Data compared using two-way ANOVA followed by post hoc Fisher’s LSD test. Protein carbonyls contents Our data showed that US stress led to increased protein carbonylation, indicative of oxidative stress (Fig. 3) in the hippocampus (F6,63=14.76, p<0.01, two-way ANOVA) and prefrontal cortex (F6,63=19.9, p<0.001, two-way ANOVA). Two and three weeks of US stress significantly changed this parameter in the prefrontal cortex and three

Anna Gorlova, Dmitrii Pavlov, Eugene Zubkov, Yana Zorkina, Anatoly Inozemtsev, Anna Morozova, Vladimir Chekhonin

Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 3, 232–238

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