to control for hyperthermia. All experiments were videotaped and the latency to the first sign of febrile seizure, including increased frequency of urination and tonic-clonic contraction, was recorded.
For induction of PTZ-induced seizure, PTZ was administrated at a dose of 80 mg/kg, 30 min after administration of normal saline (10 ml/kg), diazepam (3 mg/kg), or M8-B (3, 6, and 9 mg/kg). The experiments were videotaped and the following parameters were recorded: stage 2 (S2L) and stage 4 (S4L
Nosaibeh Riahi Zaniani,
Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 1, 86–91