minimal functional improvement. Other neuroprotective strategies such as therapeutic hypothermia alone or in combination with other interventions, whose mechanisms of action are multifactorial and may thereby protect nervous tissue and minimize overall loss of neurological function, are therefore being considered for experimental and clinical trials.
Experimental animals used in SCI studies
Although detailed descriptions of the causes and symptoms of traumatic SCI date back to ancient Egyptian times
Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 2, 172–178
compared to the control group. It is noteworthy that lowering body temperature has been introduced as an effective way of controlling seizure. Previous studies show that changes as little as 2° to 3°C in brain temperature affect neuronal properties and brain functions (Ritchie et al., 1956; Schiff et al., 1985). Hypothermia has been demonstrated to protect against seizure in both in vitro and in vivo models within seconds, without causing acute or delayed injury to the cooled brain (Inoue et al., 2017
Nosaibeh Riahi Zaniani,
Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 1, 86–91
infusion or as twice-daily treatment, eltoprazine produced a decrease in food intake and body weight at doses leading to 200–500 nM plasma concentrations.
In the elevated plus maze eltoprazine increased anxiety-like behavior. On the other hand, it induced a clear-cut anxiolytic effect in context fear conditioning test starting at ca. 0.3 mg/kg, and failed to produce any significant effect in fear potentiated startle test. Regarding adverse effects, eltoprazine was found to produce hypothermia starting
Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 1, 77–85