Research paper
Because ketamine and magnesium block NMDA receptor activation by distinct mechanisms of action, we hypothesized that in a model of inflammatory pain in rats the combination of ketamine and magnesium might be more effective than ketamine alone. Antinociceptive activity was assessed by the formalin test in male Wistar rats (200–250 g). Animals were injected with 100 μL of 2.5% formalin to the plantar surface of the right hind paw. Data were recorded as the total time spent in pain-related
Katarina Savić Vujović,
Sonja Vučković,
Dolika Vasović,
Branislava Medić,
Nick Knežević,
Milica Prostran
Acta Neurobiologiae Experimentalis , ISSUE 2, 137–146
Research paper
Bipolar disorder is a chronic disease characterized by recurring episodes of mania and depression that can lead to disability. This study investigates the protective effects of edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a drug with well-known antioxidant properties, in a model of mania induced by ketamine in rats. Locomotor activity was assessed in the open-field test. Superoxide dismutase (SOD), catalase (CAT) and thiobarbituric acid reactive substances (TBARS) levels were measured in
Filiz Civil Arslan,
Ahmet Tiryaki,
Mehmet Yıldırım,
Evrim Özkorumak,
Ahmet Alver,
İlkay Keleş Altun,
İmran İnce,
Öznur Gedikli
Acta Neurobiologiae Experimentalis , ISSUE 3, 192–198